Insulin's impact on renal sodium transport and blood pressure in health, obesity, and diabetes
Insulin has been shown to have antinatriuretic actions in humans and animal models. Moreover, endogenous hyperinsulinemia and insulin infusion have been correlated to increased blood pressure in some models. In this review, we present the current state of understanding with regard to the regulation...
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Veröffentlicht in: | American journal of physiology. Renal physiology 2007-10, Vol.293 (4), p.F974-F984 |
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container_title | American journal of physiology. Renal physiology |
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creator | Tiwari, Swasti Riazi, Shahla Ecelbarger, Carolyn A |
description | Insulin has been shown to have antinatriuretic actions in humans and animal models. Moreover, endogenous hyperinsulinemia and insulin infusion have been correlated to increased blood pressure in some models. In this review, we present the current state of understanding with regard to the regulation of the major renal sodium transporters by insulin in the kidney. Several groups, using primarily cell culture, have demonstrated that insulin can directly increase activity of the epithelial sodium channel, the sodium-phosphate cotransporter, the sodium-hydrogen exchanger type III, and Na-K-ATPase. We and others have demonstrated alterations in the expression at the protein level of many of these same proteins with insulin infusion or in hyperinsulinemic models. We also discuss how this regulation is perturbed in type I and type II diabetes mellitus. Finally, we discuss a potential role for regulation of insulin receptor signaling in the kidney in contributing to sodium balance and blood pressure. |
doi_str_mv | 10.1152/ajprenal.00149.2007 |
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Finally, we discuss a potential role for regulation of insulin receptor signaling in the kidney in contributing to sodium balance and blood pressure.</description><identifier>ISSN: 1931-857X</identifier><identifier>EISSN: 1522-1466</identifier><identifier>DOI: 10.1152/ajprenal.00149.2007</identifier><identifier>PMID: 17686957</identifier><language>eng</language><publisher>United States: American Physiological Society</publisher><subject>Animals ; Biological Transport - physiology ; Blood pressure ; Blood Pressure - physiology ; Cell culture ; Diabetes Mellitus - physiopathology ; Endocrinology ; Humans ; Insulin ; Insulin - physiology ; Kidney - metabolism ; Kidneys ; Obesity - physiopathology ; Sodium - metabolism</subject><ispartof>American journal of physiology. 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Renal physiology</title><addtitle>Am J Physiol Renal Physiol</addtitle><description>Insulin has been shown to have antinatriuretic actions in humans and animal models. Moreover, endogenous hyperinsulinemia and insulin infusion have been correlated to increased blood pressure in some models. In this review, we present the current state of understanding with regard to the regulation of the major renal sodium transporters by insulin in the kidney. Several groups, using primarily cell culture, have demonstrated that insulin can directly increase activity of the epithelial sodium channel, the sodium-phosphate cotransporter, the sodium-hydrogen exchanger type III, and Na-K-ATPase. We and others have demonstrated alterations in the expression at the protein level of many of these same proteins with insulin infusion or in hyperinsulinemic models. We also discuss how this regulation is perturbed in type I and type II diabetes mellitus. Finally, we discuss a potential role for regulation of insulin receptor signaling in the kidney in contributing to sodium balance and blood pressure.</description><subject>Animals</subject><subject>Biological Transport - physiology</subject><subject>Blood pressure</subject><subject>Blood Pressure - physiology</subject><subject>Cell culture</subject><subject>Diabetes Mellitus - physiopathology</subject><subject>Endocrinology</subject><subject>Humans</subject><subject>Insulin</subject><subject>Insulin - physiology</subject><subject>Kidney - metabolism</subject><subject>Kidneys</subject><subject>Obesity - physiopathology</subject><subject>Sodium - metabolism</subject><issn>1931-857X</issn><issn>1522-1466</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkEtLAzEQx4Motj4-gSDBg166Na8mm6MUH4WCFwVPhmST0i27mzWze_Dbu32I4GkG5jf_YX4IXVEypXTG7u2mTaGx1ZQQKvSUEaKO0HiYsIwKKY-HXnOa5TP1MUJnABsygJTRUzSiSuZSz9QYfS4a6KuyuQNc1q0tOhwbvIvFEH3Z17hLtoE2pg7bxmNXxejxcBigTwGXDV4HW3XrCY4uQNl9T3aYL60LXYALdLKyFYTLQz1H70-Pb_OXbPn6vJg_LLNC5LLLCumc144IQgNxOjDKuF8JL6lmPFcFkYV2geVWrArGlReBesXdzAvvtbCKn6PbfW6b4lcfoDN1CUWoKtuE2IOROeeKiC148w_cxD4N74JhnNDBJNMDxPdQkSJACivTprK26dtQYrbuza97s3Nvtu6HretDdO_q4P92DrL5D9S4gkA</recordid><startdate>20071001</startdate><enddate>20071001</enddate><creator>Tiwari, Swasti</creator><creator>Riazi, Shahla</creator><creator>Ecelbarger, Carolyn A</creator><general>American Physiological Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20071001</creationdate><title>Insulin's impact on renal sodium transport and blood pressure in health, obesity, and diabetes</title><author>Tiwari, Swasti ; Riazi, Shahla ; Ecelbarger, Carolyn A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-c6bbd9b0401e0b9e2123df4d6192387c06c9be28a4fc237d4e1d73b5d4dd94a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Biological Transport - physiology</topic><topic>Blood pressure</topic><topic>Blood Pressure - physiology</topic><topic>Cell culture</topic><topic>Diabetes Mellitus - physiopathology</topic><topic>Endocrinology</topic><topic>Humans</topic><topic>Insulin</topic><topic>Insulin - physiology</topic><topic>Kidney - metabolism</topic><topic>Kidneys</topic><topic>Obesity - physiopathology</topic><topic>Sodium - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tiwari, Swasti</creatorcontrib><creatorcontrib>Riazi, Shahla</creatorcontrib><creatorcontrib>Ecelbarger, Carolyn A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology. 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subjects | Animals Biological Transport - physiology Blood pressure Blood Pressure - physiology Cell culture Diabetes Mellitus - physiopathology Endocrinology Humans Insulin Insulin - physiology Kidney - metabolism Kidneys Obesity - physiopathology Sodium - metabolism |
title | Insulin's impact on renal sodium transport and blood pressure in health, obesity, and diabetes |
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