Alendronate Has an Anabolic Effect on Bone Through the Differentiation of Mesenchymal Stem Cells

We committed MSCs to differentiate into either osteoblasts or adipocytes and examined the effect of ALN on both adipogenesis and osteoblastogenesis. ALN inhibited adipogenesis while promoting osteoblast differentiation and activity. Our results reveal a new anabolic effect of ALN in differentiating...

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Veröffentlicht in:	Journal of bone and mineral research 2007-10, Vol.22 (10), p.1603-1611
Hauptverfasser:	Duque, Gustavo, Rivas, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes - cytology Adipocytes - drug effects adipogenesis alendronate Alendronate - metabolism Alendronate - pharmacology Anabolic Agents - pharmacology Biological and medical sciences Bone and Bones - cytology Bone and Bones - drug effects Bone and Bones - metabolism Calcitriol - pharmacology Cell Differentiation - drug effects Cell Proliferation - drug effects Cells, Cultured Fundamental and applied biological sciences. Psychology Humans mesenchymal stem cells Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - drug effects osteoblastogenesis Osteoclasts - cytology Osteoclasts - drug effects osteoporosis PPAR gamma - metabolism Skeleton and joints Vertebrates: osteoarticular system, musculoskeletal system
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