Clinical improvement and shrinkage of uterine fibroids after thermal ablation by magnetic resonance‐guided focused ultrasound surgery
Objective Hysterectomy or myomectomy are the accepted treatments for symptomatic uterine fibroids. Heat ablation of uterine fibroids has been shown to be an effective alternative treatment. The aim of this study was to determine the clinical efficacy of non‐invasive thermal ablation by transcutaneou...
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| Veröffentlicht in: | Ultrasound in obstetrics & gynecology 2007-10, Vol.30 (5), p.771-777 |
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| container_title | Ultrasound in obstetrics & gynecology |
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| creator | Rabinovici, J. Inbar, Y. Revel, A. Zalel, Y. Gomori, J. M. Itzchak, Y. Schiff, E. Yagel, S. |
| description | Objective
Hysterectomy or myomectomy are the accepted treatments for symptomatic uterine fibroids. Heat ablation of uterine fibroids has been shown to be an effective alternative treatment. The aim of this study was to determine the clinical efficacy of non‐invasive thermal ablation by transcutaneous magnetic resonance‐guided high‐intensity focused ultrasound (MRgFUS) for the treatment of symptomatic uterine fibroids.
Methods
In this prospective study, MRgFUS ablation of uterine fibroids was performed in 35 symptomatic women scheduled for hysterectomy. Clinical symptoms, patient satisfaction and uterine size were determined at 1 month and 6 months after the procedure.
Results
This outpatient procedure was very well tolerated by all women. Sixty‐nine percent (24/35) of the treated patients reported either significant or partial improvement in symptoms. Treated fibroids decreased in volume by 12% and 15% at 1 and 6 months, respectively. Minor transient side‐effects were observed in two women. Six women underwent hysterectomy during the follow‐up period.
Conclusion
This study demonstrates the clinical efficacy of MRgFUS ablation of uterine fibroids. This novel, non‐invasive surgical approach may offer an alternative therapy for women with uterine fibroids. Copyright © 2007 ISUOG. Published by John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/uog.4099 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68336513</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68336513</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4809-1e126bb8fcbd1de8f8d97cf84c5af27c778152c4eda76dfdd55dd42310ffc40a3</originalsourceid><addsrcrecordid>eNqFkb9uFDEQhy1ERI6AxBMgNyCaTWyv139KdIKAFClNUq-89nhj2F0Hew26jo6WZ-RJ8HEnpUKpRjP6PD-NP4ReUXJOCWEXJY7nnGj9BG0oF7ohknRP0YZoQRopNDtFz3P-QggRvBXP0CmVSutOyg36tZ3CEqyZcJjvU_wOMywrNovD-S6F5asZAUePywq1A-zDkGJwGRtfJ3i9gzTXt2aYzBrigocdns24wBosTpDjYhYLf37-Hktw4LCPtuRay7Qmk2PZx5Q0Qtq9QCfeTBleHusZuv344Wb7qbm6vvy8fX_VWK6IbihQJoZBeTs46kB55bS0XnHbGc-klVLRjlkOzkjhvHNd5xxnLSXeW05Me4beHvbWY78VyGs_h2xhmswCseReqLYVHW0fBRklolVMVfDdAbQp5pzA9_cpzCbtekr6vZ2-2un3dir6-rizDDO4B_CoowJvjoDJ1YlP9ftCfuA05UxIVrnmwP0IE-z-G9jfXl_-C_4LqAmrVQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>21063828</pqid></control><display><type>article</type><title>Clinical improvement and shrinkage of uterine fibroids after thermal ablation by magnetic resonance‐guided focused ultrasound surgery</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Access via Wiley Online Library</source><source>Wiley Online Library (Open Access Collection)</source><creator>Rabinovici, J. ; Inbar, Y. ; Revel, A. ; Zalel, Y. ; Gomori, J. M. ; Itzchak, Y. ; Schiff, E. ; Yagel, S.</creator><creatorcontrib>Rabinovici, J. ; Inbar, Y. ; Revel, A. ; Zalel, Y. ; Gomori, J. M. ; Itzchak, Y. ; Schiff, E. ; Yagel, S.</creatorcontrib><description>Objective
Hysterectomy or myomectomy are the accepted treatments for symptomatic uterine fibroids. Heat ablation of uterine fibroids has been shown to be an effective alternative treatment. The aim of this study was to determine the clinical efficacy of non‐invasive thermal ablation by transcutaneous magnetic resonance‐guided high‐intensity focused ultrasound (MRgFUS) for the treatment of symptomatic uterine fibroids.
Methods
In this prospective study, MRgFUS ablation of uterine fibroids was performed in 35 symptomatic women scheduled for hysterectomy. Clinical symptoms, patient satisfaction and uterine size were determined at 1 month and 6 months after the procedure.
Results
This outpatient procedure was very well tolerated by all women. Sixty‐nine percent (24/35) of the treated patients reported either significant or partial improvement in symptoms. Treated fibroids decreased in volume by 12% and 15% at 1 and 6 months, respectively. Minor transient side‐effects were observed in two women. Six women underwent hysterectomy during the follow‐up period.
Conclusion
This study demonstrates the clinical efficacy of MRgFUS ablation of uterine fibroids. This novel, non‐invasive surgical approach may offer an alternative therapy for women with uterine fibroids. Copyright © 2007 ISUOG. Published by John Wiley & Sons, Ltd.</description><identifier>ISSN: 0960-7692</identifier><identifier>EISSN: 1469-0705</identifier><identifier>DOI: 10.1002/uog.4099</identifier><identifier>PMID: 17899577</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Biological and medical sciences ; Catheter Ablation - methods ; Female ; Female genital diseases ; Gynecology. Andrology. Obstetrics ; heat ablation ; HIFUS ; Humans ; Leiomyoma - pathology ; Leiomyoma - surgery ; Magnetic Resonance Imaging, Interventional - methods ; Medical sciences ; Middle Aged ; non‐invasive surgery ; Other treatments ; Prospective Studies ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; therapeutic ultrasound ; Treatment Outcome ; Treatment. General aspects ; Tumors ; Ultrasonic Therapy - methods ; uterine myoma</subject><ispartof>Ultrasound in obstetrics & gynecology, 2007-10, Vol.30 (5), p.771-777</ispartof><rights>Copyright © 2007 ISUOG. Published by John Wiley & Sons, Ltd.</rights><rights>2007 INIST-CNRS</rights><rights>Copyright (c) 2007 ISUOG</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4809-1e126bb8fcbd1de8f8d97cf84c5af27c778152c4eda76dfdd55dd42310ffc40a3</citedby><cites>FETCH-LOGICAL-c4809-1e126bb8fcbd1de8f8d97cf84c5af27c778152c4eda76dfdd55dd42310ffc40a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fuog.4099$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fuog.4099$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,1435,27931,27932,45581,45582,46416,46840</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19142672$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17899577$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rabinovici, J.</creatorcontrib><creatorcontrib>Inbar, Y.</creatorcontrib><creatorcontrib>Revel, A.</creatorcontrib><creatorcontrib>Zalel, Y.</creatorcontrib><creatorcontrib>Gomori, J. M.</creatorcontrib><creatorcontrib>Itzchak, Y.</creatorcontrib><creatorcontrib>Schiff, E.</creatorcontrib><creatorcontrib>Yagel, S.</creatorcontrib><title>Clinical improvement and shrinkage of uterine fibroids after thermal ablation by magnetic resonance‐guided focused ultrasound surgery</title><title>Ultrasound in obstetrics & gynecology</title><addtitle>Ultrasound Obstet Gynecol</addtitle><description>Objective
Hysterectomy or myomectomy are the accepted treatments for symptomatic uterine fibroids. Heat ablation of uterine fibroids has been shown to be an effective alternative treatment. The aim of this study was to determine the clinical efficacy of non‐invasive thermal ablation by transcutaneous magnetic resonance‐guided high‐intensity focused ultrasound (MRgFUS) for the treatment of symptomatic uterine fibroids.
Methods
In this prospective study, MRgFUS ablation of uterine fibroids was performed in 35 symptomatic women scheduled for hysterectomy. Clinical symptoms, patient satisfaction and uterine size were determined at 1 month and 6 months after the procedure.
Results
This outpatient procedure was very well tolerated by all women. Sixty‐nine percent (24/35) of the treated patients reported either significant or partial improvement in symptoms. Treated fibroids decreased in volume by 12% and 15% at 1 and 6 months, respectively. Minor transient side‐effects were observed in two women. Six women underwent hysterectomy during the follow‐up period.
Conclusion
This study demonstrates the clinical efficacy of MRgFUS ablation of uterine fibroids. This novel, non‐invasive surgical approach may offer an alternative therapy for women with uterine fibroids. Copyright © 2007 ISUOG. Published by John Wiley & Sons, Ltd.</description><subject>Biological and medical sciences</subject><subject>Catheter Ablation - methods</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>heat ablation</subject><subject>HIFUS</subject><subject>Humans</subject><subject>Leiomyoma - pathology</subject><subject>Leiomyoma - surgery</subject><subject>Magnetic Resonance Imaging, Interventional - methods</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>non‐invasive surgery</subject><subject>Other treatments</subject><subject>Prospective Studies</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>therapeutic ultrasound</subject><subject>Treatment Outcome</subject><subject>Treatment. General aspects</subject><subject>Tumors</subject><subject>Ultrasonic Therapy - methods</subject><subject>uterine myoma</subject><issn>0960-7692</issn><issn>1469-0705</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkb9uFDEQhy1ERI6AxBMgNyCaTWyv139KdIKAFClNUq-89nhj2F0Hew26jo6WZ-RJ8HEnpUKpRjP6PD-NP4ReUXJOCWEXJY7nnGj9BG0oF7ohknRP0YZoQRopNDtFz3P-QggRvBXP0CmVSutOyg36tZ3CEqyZcJjvU_wOMywrNovD-S6F5asZAUePywq1A-zDkGJwGRtfJ3i9gzTXt2aYzBrigocdns24wBosTpDjYhYLf37-Hktw4LCPtuRay7Qmk2PZx5Q0Qtq9QCfeTBleHusZuv344Wb7qbm6vvy8fX_VWK6IbihQJoZBeTs46kB55bS0XnHbGc-klVLRjlkOzkjhvHNd5xxnLSXeW05Me4beHvbWY78VyGs_h2xhmswCseReqLYVHW0fBRklolVMVfDdAbQp5pzA9_cpzCbtekr6vZ2-2un3dir6-rizDDO4B_CoowJvjoDJ1YlP9ftCfuA05UxIVrnmwP0IE-z-G9jfXl_-C_4LqAmrVQ</recordid><startdate>200710</startdate><enddate>200710</enddate><creator>Rabinovici, J.</creator><creator>Inbar, Y.</creator><creator>Revel, A.</creator><creator>Zalel, Y.</creator><creator>Gomori, J. M.</creator><creator>Itzchak, Y.</creator><creator>Schiff, E.</creator><creator>Yagel, S.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200710</creationdate><title>Clinical improvement and shrinkage of uterine fibroids after thermal ablation by magnetic resonance‐guided focused ultrasound surgery</title><author>Rabinovici, J. ; Inbar, Y. ; Revel, A. ; Zalel, Y. ; Gomori, J. M. ; Itzchak, Y. ; Schiff, E. ; Yagel, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4809-1e126bb8fcbd1de8f8d97cf84c5af27c778152c4eda76dfdd55dd42310ffc40a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Biological and medical sciences</topic><topic>Catheter Ablation - methods</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>heat ablation</topic><topic>HIFUS</topic><topic>Humans</topic><topic>Leiomyoma - pathology</topic><topic>Leiomyoma - surgery</topic><topic>Magnetic Resonance Imaging, Interventional - methods</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>non‐invasive surgery</topic><topic>Other treatments</topic><topic>Prospective Studies</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>therapeutic ultrasound</topic><topic>Treatment Outcome</topic><topic>Treatment. General aspects</topic><topic>Tumors</topic><topic>Ultrasonic Therapy - methods</topic><topic>uterine myoma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rabinovici, J.</creatorcontrib><creatorcontrib>Inbar, Y.</creatorcontrib><creatorcontrib>Revel, A.</creatorcontrib><creatorcontrib>Zalel, Y.</creatorcontrib><creatorcontrib>Gomori, J. M.</creatorcontrib><creatorcontrib>Itzchak, Y.</creatorcontrib><creatorcontrib>Schiff, E.</creatorcontrib><creatorcontrib>Yagel, S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Ultrasound in obstetrics & gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rabinovici, J.</au><au>Inbar, Y.</au><au>Revel, A.</au><au>Zalel, Y.</au><au>Gomori, J. M.</au><au>Itzchak, Y.</au><au>Schiff, E.</au><au>Yagel, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical improvement and shrinkage of uterine fibroids after thermal ablation by magnetic resonance‐guided focused ultrasound surgery</atitle><jtitle>Ultrasound in obstetrics & gynecology</jtitle><addtitle>Ultrasound Obstet Gynecol</addtitle><date>2007-10</date><risdate>2007</risdate><volume>30</volume><issue>5</issue><spage>771</spage><epage>777</epage><pages>771-777</pages><issn>0960-7692</issn><eissn>1469-0705</eissn><abstract>Objective
Hysterectomy or myomectomy are the accepted treatments for symptomatic uterine fibroids. Heat ablation of uterine fibroids has been shown to be an effective alternative treatment. The aim of this study was to determine the clinical efficacy of non‐invasive thermal ablation by transcutaneous magnetic resonance‐guided high‐intensity focused ultrasound (MRgFUS) for the treatment of symptomatic uterine fibroids.
Methods
In this prospective study, MRgFUS ablation of uterine fibroids was performed in 35 symptomatic women scheduled for hysterectomy. Clinical symptoms, patient satisfaction and uterine size were determined at 1 month and 6 months after the procedure.
Results
This outpatient procedure was very well tolerated by all women. Sixty‐nine percent (24/35) of the treated patients reported either significant or partial improvement in symptoms. Treated fibroids decreased in volume by 12% and 15% at 1 and 6 months, respectively. Minor transient side‐effects were observed in two women. Six women underwent hysterectomy during the follow‐up period.
Conclusion
This study demonstrates the clinical efficacy of MRgFUS ablation of uterine fibroids. This novel, non‐invasive surgical approach may offer an alternative therapy for women with uterine fibroids. Copyright © 2007 ISUOG. Published by John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>17899577</pmid><doi>10.1002/uog.4099</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0960-7692 |
| ispartof | Ultrasound in obstetrics & gynecology, 2007-10, Vol.30 (5), p.771-777 |
| issn | 0960-7692 1469-0705 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Access via Wiley Online Library; Wiley Online Library (Open Access Collection) |
| subjects | Biological and medical sciences Catheter Ablation - methods Female Female genital diseases Gynecology. Andrology. Obstetrics heat ablation HIFUS Humans Leiomyoma - pathology Leiomyoma - surgery Magnetic Resonance Imaging, Interventional - methods Medical sciences Middle Aged non‐invasive surgery Other treatments Prospective Studies Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) therapeutic ultrasound Treatment Outcome Treatment. General aspects Tumors Ultrasonic Therapy - methods uterine myoma |
| title | Clinical improvement and shrinkage of uterine fibroids after thermal ablation by magnetic resonance‐guided focused ultrasound surgery |
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