Assessment of risk factors for cardiovasuclar disease in pediatric renal transplant patients
: Pediatric renal TP recipients are at risk for CVD. We performed a cross‐sectional study of the prevalence of RF for CVD in 45 long‐term pediatric renal TP patients. The time since TP was 42 months. The GFR was 87.8 ± 3.4 mL/min/1.73m2; 25/45 (56%) had Stage 2–4 CKD. A total of 33% had elevated SB...
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| Veröffentlicht in: | Pediatric transplantation 2007-11, Vol.11 (7), p.721-729 |
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| creator | Silverstein, Douglas M. Mitchell, Miranda LeBlanc, Pamela Boudreaux, J. Philip |
| description | : Pediatric renal TP recipients are at risk for CVD. We performed a cross‐sectional study of the prevalence of RF for CVD in 45 long‐term pediatric renal TP patients. The time since TP was 42 months. The GFR was 87.8 ± 3.4 mL/min/1.73m2; 25/45 (56%) had Stage 2–4 CKD. A total of 33% had elevated SBP and 24% had high DBP; 57% had elevated SBP or DBP. A total of 20% had elevated serum CHOL levels, while 45% had high serum TG levels. A total of 42% had high HCY levels and 50% had low HCT levels. The vast majority (66.7%) had at least two RF for CVD. A total of 18.2% had abnormal post‐TP echocardiography results. There was a negative correlation between GFR and SBP, DBP, serum CHOL, HCY, and BMI. There was a positive correlation between GFR and HCT. Serum CHOL was significantly lower and SBP and DBP trended lower in patients on a SF immunosuppression regimen. Similarly, SBP and DBP trended higher and CHOL was significantly higher in patients receiving SRL vs. mycophenolate mofetil. We conclude that the majority of pediatric renal TP patients exhibit multiple CVD RF. |
| doi_str_mv | 10.1111/j.1399-3046.2007.00730.x |
| format | Article |
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Philip</creator><creatorcontrib>Silverstein, Douglas M. ; Mitchell, Miranda ; LeBlanc, Pamela ; Boudreaux, J. Philip</creatorcontrib><description>: Pediatric renal TP recipients are at risk for CVD. We performed a cross‐sectional study of the prevalence of RF for CVD in 45 long‐term pediatric renal TP patients. The time since TP was 42 months. The GFR was 87.8 ± 3.4 mL/min/1.73m2; 25/45 (56%) had Stage 2–4 CKD. A total of 33% had elevated SBP and 24% had high DBP; 57% had elevated SBP or DBP. A total of 20% had elevated serum CHOL levels, while 45% had high serum TG levels. A total of 42% had high HCY levels and 50% had low HCT levels. The vast majority (66.7%) had at least two RF for CVD. A total of 18.2% had abnormal post‐TP echocardiography results. There was a negative correlation between GFR and SBP, DBP, serum CHOL, HCY, and BMI. There was a positive correlation between GFR and HCT. Serum CHOL was significantly lower and SBP and DBP trended lower in patients on a SF immunosuppression regimen. Similarly, SBP and DBP trended higher and CHOL was significantly higher in patients receiving SRL vs. mycophenolate mofetil. We conclude that the majority of pediatric renal TP patients exhibit multiple CVD RF.</description><identifier>ISSN: 1397-3142</identifier><identifier>EISSN: 1399-3046</identifier><identifier>DOI: 10.1111/j.1399-3046.2007.00730.x</identifier><identifier>PMID: 17910648</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Blood Pressure ; Cadaver ; cardiovascular ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - physiopathology ; Child ; Cross-Sectional Studies ; Echocardiography ; Epidemiology ; General aspects ; Humans ; Kidney Failure, Chronic - surgery ; Kidney Transplantation - adverse effects ; Living Donors ; Medical sciences ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; Patient Selection ; Postoperative Complications - epidemiology ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; renal ; Renal failure ; Risk Factors ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Tissue Donors ; transplant</subject><ispartof>Pediatric transplantation, 2007-11, Vol.11 (7), p.721-729</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4350-16e9ebd70b9bcdafd76fb2b6db791dac9dbc6ca9a44d489d5d917ec719a70bc03</citedby><cites>FETCH-LOGICAL-c4350-16e9ebd70b9bcdafd76fb2b6db791dac9dbc6ca9a44d489d5d917ec719a70bc03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1399-3046.2007.00730.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1399-3046.2007.00730.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19141755$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17910648$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Silverstein, Douglas M.</creatorcontrib><creatorcontrib>Mitchell, Miranda</creatorcontrib><creatorcontrib>LeBlanc, Pamela</creatorcontrib><creatorcontrib>Boudreaux, J. Philip</creatorcontrib><title>Assessment of risk factors for cardiovasuclar disease in pediatric renal transplant patients</title><title>Pediatric transplantation</title><addtitle>Pediatr Transplant</addtitle><description>: Pediatric renal TP recipients are at risk for CVD. We performed a cross‐sectional study of the prevalence of RF for CVD in 45 long‐term pediatric renal TP patients. The time since TP was 42 months. The GFR was 87.8 ± 3.4 mL/min/1.73m2; 25/45 (56%) had Stage 2–4 CKD. A total of 33% had elevated SBP and 24% had high DBP; 57% had elevated SBP or DBP. A total of 20% had elevated serum CHOL levels, while 45% had high serum TG levels. A total of 42% had high HCY levels and 50% had low HCT levels. The vast majority (66.7%) had at least two RF for CVD. A total of 18.2% had abnormal post‐TP echocardiography results. There was a negative correlation between GFR and SBP, DBP, serum CHOL, HCY, and BMI. There was a positive correlation between GFR and HCT. Serum CHOL was significantly lower and SBP and DBP trended lower in patients on a SF immunosuppression regimen. Similarly, SBP and DBP trended higher and CHOL was significantly higher in patients receiving SRL vs. mycophenolate mofetil. We conclude that the majority of pediatric renal TP patients exhibit multiple CVD RF.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure</subject><subject>Cadaver</subject><subject>cardiovascular</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cardiovascular Diseases - physiopathology</subject><subject>Child</subject><subject>Cross-Sectional Studies</subject><subject>Echocardiography</subject><subject>Epidemiology</subject><subject>General aspects</subject><subject>Humans</subject><subject>Kidney Failure, Chronic - surgery</subject><subject>Kidney Transplantation - adverse effects</subject><subject>Living Donors</subject><subject>Medical sciences</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nephropathies. Renovascular diseases. Renal failure</subject><subject>Patient Selection</subject><subject>Postoperative Complications - epidemiology</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>renal</subject><subject>Renal failure</subject><subject>Risk Factors</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Tissue Donors</subject><subject>transplant</subject><issn>1397-3142</issn><issn>1399-3046</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMFu1DAQhi0EoqXwCsgXuCW1YyeODxxK1S2oFVSoiAuSNbEnkrfZTfBky_bt8XZX7RVLlkfy98-MPsa4FKXM53RZSmVtoYRuykoIU-arRLl9wY6fPl4-1qZQUldH7A3RUgjZ6Fa_ZkfSWClyfcx-nxEh0QrXMx97niLd8R78PCbi_Zi4hxTieA-08QMkHiIhEPK45hOGCHOKnidcw8DnBGuaBsiNJphjbkhv2aseBsJ3h_eE_Vxc3J5_Ka6_X349P7suvFa1KGSDFrtgRGc7H6APpum7qmtCl9cM4G3ofOPBgtZBtzbUwUqD3kgLOeOFOmEf932nNP7ZIM1uFcnjkJfBcUOuaZWqq6rNYLsHfRqJEvZuSnEF6cFJ4XZm3dLtBLqdQLcz6x7Num2Ovj_M2HQrDM_Bg8oMfDgAQB6GPuvwkZ45K7U0dZ25T3vubxzw4b8XcDcXtz9ylfPFPh9pxu1THtKda4wytfv17dLJq4XSn28qt1D_AHpFpgE</recordid><startdate>200711</startdate><enddate>200711</enddate><creator>Silverstein, Douglas M.</creator><creator>Mitchell, Miranda</creator><creator>LeBlanc, Pamela</creator><creator>Boudreaux, J. Philip</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200711</creationdate><title>Assessment of risk factors for cardiovasuclar disease in pediatric renal transplant patients</title><author>Silverstein, Douglas M. ; Mitchell, Miranda ; LeBlanc, Pamela ; Boudreaux, J. Philip</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4350-16e9ebd70b9bcdafd76fb2b6db791dac9dbc6ca9a44d489d5d917ec719a70bc03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure</topic><topic>Cadaver</topic><topic>cardiovascular</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cardiovascular Diseases - physiopathology</topic><topic>Child</topic><topic>Cross-Sectional Studies</topic><topic>Echocardiography</topic><topic>Epidemiology</topic><topic>General aspects</topic><topic>Humans</topic><topic>Kidney Failure, Chronic - surgery</topic><topic>Kidney Transplantation - adverse effects</topic><topic>Living Donors</topic><topic>Medical sciences</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Nephropathies. Renovascular diseases. Renal failure</topic><topic>Patient Selection</topic><topic>Postoperative Complications - epidemiology</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>renal</topic><topic>Renal failure</topic><topic>Risk Factors</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Tissue Donors</topic><topic>transplant</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Silverstein, Douglas M.</creatorcontrib><creatorcontrib>Mitchell, Miranda</creatorcontrib><creatorcontrib>LeBlanc, Pamela</creatorcontrib><creatorcontrib>Boudreaux, J. Philip</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Silverstein, Douglas M.</au><au>Mitchell, Miranda</au><au>LeBlanc, Pamela</au><au>Boudreaux, J. Philip</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of risk factors for cardiovasuclar disease in pediatric renal transplant patients</atitle><jtitle>Pediatric transplantation</jtitle><addtitle>Pediatr Transplant</addtitle><date>2007-11</date><risdate>2007</risdate><volume>11</volume><issue>7</issue><spage>721</spage><epage>729</epage><pages>721-729</pages><issn>1397-3142</issn><eissn>1399-3046</eissn><abstract>: Pediatric renal TP recipients are at risk for CVD. We performed a cross‐sectional study of the prevalence of RF for CVD in 45 long‐term pediatric renal TP patients. The time since TP was 42 months. The GFR was 87.8 ± 3.4 mL/min/1.73m2; 25/45 (56%) had Stage 2–4 CKD. A total of 33% had elevated SBP and 24% had high DBP; 57% had elevated SBP or DBP. A total of 20% had elevated serum CHOL levels, while 45% had high serum TG levels. A total of 42% had high HCY levels and 50% had low HCT levels. The vast majority (66.7%) had at least two RF for CVD. A total of 18.2% had abnormal post‐TP echocardiography results. There was a negative correlation between GFR and SBP, DBP, serum CHOL, HCY, and BMI. There was a positive correlation between GFR and HCT. Serum CHOL was significantly lower and SBP and DBP trended lower in patients on a SF immunosuppression regimen. Similarly, SBP and DBP trended higher and CHOL was significantly higher in patients receiving SRL vs. mycophenolate mofetil. We conclude that the majority of pediatric renal TP patients exhibit multiple CVD RF.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>17910648</pmid><doi>10.1111/j.1399-3046.2007.00730.x</doi><tpages>9</tpages></addata></record> |
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| ispartof | Pediatric transplantation, 2007-11, Vol.11 (7), p.721-729 |
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| subjects | Adolescent Adult Biological and medical sciences Blood Pressure Cadaver cardiovascular Cardiovascular Diseases - epidemiology Cardiovascular Diseases - physiopathology Child Cross-Sectional Studies Echocardiography Epidemiology General aspects Humans Kidney Failure, Chronic - surgery Kidney Transplantation - adverse effects Living Donors Medical sciences Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Patient Selection Postoperative Complications - epidemiology Public health. Hygiene Public health. Hygiene-occupational medicine renal Renal failure Risk Factors Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tissue Donors transplant |
| title | Assessment of risk factors for cardiovasuclar disease in pediatric renal transplant patients |
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