Hypercalcaemia and malignant lymphoma. One case report

Hypercalcaemia occurs in less than 15% of lymphomas but is associated with a poor prognosis. A patient known to have a testicular lymphoma was admitted because of asthenia and weight loss. Hypercalcemia and high serum level of calcitriol were found. A high-grade lymphoma attesting a Richter's s...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	La revue de medecine interne 2007-10, Vol.28 (10), p.714-715
Hauptverfasser:	Frein, D, Lavigne, C, Josselin, N, Foussard, C, Sivova, N, Moles, M-P, Berrut, G
Format:	Artikel
Sprache:	eng ; fre
Schlagworte:	Aged, 80 and over Bone Density Conservation Agents - therapeutic use Calcitriol - blood Diphosphonates - therapeutic use Glucocorticoids - therapeutic use Humans Hypercalcemia - etiology Lymphoma, Non-Hodgkin - complications Male Palliative Care Prednisone - therapeutic use Testicular Neoplasms - complications
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Hypercalcaemia occurs in less than 15% of lymphomas but is associated with a poor prognosis. A patient known to have a testicular lymphoma was admitted because of asthenia and weight loss. Hypercalcemia and high serum level of calcitriol were found. A high-grade lymphoma attesting a Richter's syndrome was diagnosed. Palliative treatment consisting in corticosteroids and pamidronate was instituted. Hypercalcaemia in lymphoma has a poor prognosis and is often attributed to an acquired uncontrolled vitamin D 1-alpha-hydroxylase activity by the macrophages close to the lymphomatous cells. Influences of TNFalpha, interleukine 6 and PTHrp are also reported.
ISSN:	0248-8663
DOI:	10.1016/j.revmed.2007.05.002