Altered methionine metabolism and global DNA methylation in liver cancer: Relationship with genomic instability and prognosis

Mounting evidence underlines the role of genomic hypomethylation in the generation of genomic instability (GI) and tumorigenesis, but whether DNA hypomethylation is required for hepatocellular carcinoma (HCC) development and progression remains unclear. We investigated the correlation between GI and...

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Veröffentlicht in:	International journal of cancer 2007-12, Vol.121 (11), p.2410-2420
Hauptverfasser:	Calvisi, Diego F., Simile, Maria M., Ladu, Sara, Pellegrino, Rossella, De Murtas, Valentina, Pinna, Federico, Tomasi, Maria L., Frau, Maddalena, Virdis, Patrizia, De Miglio, Maria R., Muroni, Maria R., Pascale, Rosa M., Feo, Francesco
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biological and medical sciences Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Proliferation DNA hypomethylation DNA Methylation DNA, Neoplasm Gastroenterology. Liver. Pancreas. Abdomen Genes, myc Genomic Instability hepatocellular carcinoma Humans Immunoblotting Liver - metabolism Liver - pathology Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Methionine - metabolism Mice Mice, Transgenic Prognosis Proteins - metabolism Reverse Transcriptase Polymerase Chain Reaction Survival Analysis Transforming Growth Factor alpha - genetics transgenic mice Tumors
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