Embryonic stem cells: protecting pluripotency from alloreactivity
There can be little doubt that 2006 turned out to be the annus horribilis for therapeutic cloning by somatic nuclear transfer (SNT). As the full extent of the fraud surrounding the generation of patient-specific embryonic stem (ES) cell lines became apparent, hopes began to fade for the advent of ce...
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| Veröffentlicht in: | Current Opinion in Immunology 2007-10, Vol.19 (5), p.596-602 |
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| container_title | Current Opinion in Immunology |
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| creator | Fairchild, Paul J Robertson, Nathan J Minger, Stephen L Waldmann, Herman |
| description | There can be little doubt that 2006 turned out to be the annus horribilis for therapeutic cloning by somatic nuclear transfer (SNT). As the full extent of the fraud surrounding the generation of patient-specific embryonic stem (ES) cell lines became apparent, hopes began to fade for the advent of cell replacement therapies (CRT), free from the confounding issues of immune rejection. While the dust begins to settle, it is perhaps pertinent to ask whether the promise of SNT is still worth pursuing or whether alternative strategies for immune evasion might help fill the void. |
| doi_str_mv | 10.1016/j.coi.2007.07.010 |
| format | Article |
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| identifier | ISSN: 0952-7915 |
| ispartof | Current Opinion in Immunology, 2007-10, Vol.19 (5), p.596-602 |
| issn | 0952-7915 1879-0372 1365-2567 |
| language | eng |
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| source | Wiley Free Content; MEDLINE; IngentaConnect Free/Open Access Journals; Wiley Online Library Journals Frontfile Complete; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Allergy and Immunology Animals Embryonic Stem Cells - immunology Embryonic Stem Cells - metabolism Humans Nuclear Transfer Techniques Pluripotent Stem Cells - immunology Pluripotent Stem Cells - metabolism Stem Cell Transplantation Transplantation Tolerance - immunology |
| title | Embryonic stem cells: protecting pluripotency from alloreactivity |
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