An effective method for the in situ synthesis of DNA–CPG conjugates using chemical ligation technology as tools for SNP analysis

A new method for the SNP analysis by using a chemical ligation (CL) technique on CPG plates with high coupling efficiency is reported. In this paper, we report a new method for the SNP analysis by using a chemical ligation (CL) technique on CPG plates with high coupling efficiency. This method showe...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2007-11, Vol.17 (21), p.5969-5973
Hauptverfasser:	Ohkubo, Akihiro, Tanaka, Kunihiko, Taguchi, Haruhiko, Seio, Kohji, Nagasawa, Hiroshi, Tsukahara, Toshifumi, Sekine, Mitsuo
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Thiothymidine Analytical, structural and metabolic biochemistry Base recognition Biological and medical sciences Chemical ligation Chromatography, High Pressure Liquid CpG Islands DNA - chemistry DNA Probes Dna, deoxyribonucleoproteins Fundamental and applied biological sciences. Psychology Gene detection N-unprotected DNA synthesis Nucleic acids Polymorphism, Single Nucleotide SNP
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