Misexpression of the Caenorhabditis elegans miRNA let-7 is sufficient to drive developmental programs

The Caenorhabditis elegans microRNAs (miRNAs) lin-4 and let-7 promote transitions between stage-specific events in development by down-regulating the translation of their target genes. Expression of let-7 is required at the fourth larval stage for the proper transition from larval to differentiated,...

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Veröffentlicht in:	Cold Spring Harbor Symposia on Quantitative Biology 2006, Vol.71, p.21-27
Hauptverfasser:	Hayes, G D, Ruvkun, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified Caenorhabditis elegans - genetics Caenorhabditis elegans - growth & development Caenorhabditis elegans Proteins - genetics DNA-Binding Proteins - genetics Enhancer Elements, Genetic Gene Expression Regulation, Developmental Gene Fusion MicroRNAs - genetics Phenotype Promoter Regions, Genetic RNA, Helminth - genetics Transcription Factors - genetics
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