Bcl-2-regulated apoptosis: mechanism and therapeutic potential
Apoptosis is essential for tissue homeostasis, particularly in the hematopoietic compartment, where its impairment can elicit neoplastic or autoimmune diseases. Whether stressed cells live or die is largely determined by interplay between opposing members of the Bcl-2 protein family. Bcl-2 and its c...
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| Veröffentlicht in: | Current Opinion in Immunology 2007-10, Vol.19 (5), p.488-496 |
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| creator | Adams, Jerry M Cory, Suzanne |
| description | Apoptosis is essential for tissue homeostasis, particularly in the hematopoietic compartment, where its impairment can elicit neoplastic or autoimmune diseases. Whether stressed cells live or die is largely determined by interplay between opposing members of the Bcl-2 protein family. Bcl-2 and its closest homologs promote cell survival, but two other factions promote apoptosis. The BH3-only proteins sense and relay stress signals, but commitment to apoptosis requires Bax or Bak. The BH3-only proteins appear to activate Bax and Bak indirectly, by engaging and neutralizing their pro-survival relatives, which otherwise constrain Bax and Bak from permeabilizing mitochondria. The Bcl-2 family may also regulate autophagy and mitochondrial fission/fusion. Its pro-survival members are attractive therapeutic targets in cancer and perhaps autoimmunity and viral infections. |
| doi_str_mv | 10.1016/j.coi.2007.05.004 |
| format | Article |
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Whether stressed cells live or die is largely determined by interplay between opposing members of the Bcl-2 protein family. Bcl-2 and its closest homologs promote cell survival, but two other factions promote apoptosis. The BH3-only proteins sense and relay stress signals, but commitment to apoptosis requires Bax or Bak. The BH3-only proteins appear to activate Bax and Bak indirectly, by engaging and neutralizing their pro-survival relatives, which otherwise constrain Bax and Bak from permeabilizing mitochondria. The Bcl-2 family may also regulate autophagy and mitochondrial fission/fusion. 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Cory, Suzanne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-d84cf43e1aaff29ddd0c365057a6045091e8607f0948641df8b4961253bd4c323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Allergy and Immunology</topic><topic>Animals</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Apoptosis</topic><topic>Apoptosis Regulatory Proteins - metabolism</topic><topic>Autophagy</topic><topic>BH3 Interacting Domain Death Agonist Protein - chemistry</topic><topic>BH3 Interacting Domain Death Agonist Protein - metabolism</topic><topic>Biphenyl Compounds - chemistry</topic><topic>Biphenyl Compounds - pharmacology</topic><topic>Biphenyl Compounds - therapeutic use</topic><topic>Humans</topic><topic>Metabolic Networks and Pathways</topic><topic>Mitochondria - physiology</topic><topic>Mitochondria - ultrastructure</topic><topic>Molecular Mimicry</topic><topic>Neoplasms - drug therapy</topic><topic>Nitrophenols - chemistry</topic><topic>Nitrophenols - pharmacology</topic><topic>Nitrophenols - therapeutic use</topic><topic>Piperazines - chemistry</topic><topic>Piperazines - pharmacology</topic><topic>Piperazines - therapeutic use</topic><topic>Proto-Oncogene Proteins c-bcl-2 - metabolism</topic><topic>Sulfonamides - chemistry</topic><topic>Sulfonamides - pharmacology</topic><topic>Sulfonamides - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Adams, Jerry M</creatorcontrib><creatorcontrib>Cory, Suzanne</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Current Opinion in Immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adams, Jerry M</au><au>Cory, Suzanne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bcl-2-regulated apoptosis: mechanism and therapeutic potential</atitle><jtitle>Current Opinion in Immunology</jtitle><addtitle>Curr Opin Immunol</addtitle><date>2007-10-01</date><risdate>2007</risdate><volume>19</volume><issue>5</issue><spage>488</spage><epage>496</epage><pages>488-496</pages><issn>0952-7915</issn><eissn>1879-0372</eissn><eissn>1365-2567</eissn><abstract>Apoptosis is essential for tissue homeostasis, particularly in the hematopoietic compartment, where its impairment can elicit neoplastic or autoimmune diseases. 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| source | MEDLINE; IngentaConnect Open Access Journals; Wiley Online Library Journals Frontfile Complete; Elsevier ScienceDirect Journals; Wiley Online Library Free Content; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Allergy and Immunology Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis Apoptosis Regulatory Proteins - metabolism Autophagy BH3 Interacting Domain Death Agonist Protein - chemistry BH3 Interacting Domain Death Agonist Protein - metabolism Biphenyl Compounds - chemistry Biphenyl Compounds - pharmacology Biphenyl Compounds - therapeutic use Humans Metabolic Networks and Pathways Mitochondria - physiology Mitochondria - ultrastructure Molecular Mimicry Neoplasms - drug therapy Nitrophenols - chemistry Nitrophenols - pharmacology Nitrophenols - therapeutic use Piperazines - chemistry Piperazines - pharmacology Piperazines - therapeutic use Proto-Oncogene Proteins c-bcl-2 - metabolism Sulfonamides - chemistry Sulfonamides - pharmacology Sulfonamides - therapeutic use |
| title | Bcl-2-regulated apoptosis: mechanism and therapeutic potential |
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