Clinical Usefulness of 3-Dimensional Sonography and Power Doppler Angiography for Diagnosis of Endometrial Carcinoma
Objectives The purpose of this study was to assess whether endometrial volume (EV) and 3‐dimensional (3D) power Doppler indices can discriminate between hyperplasia and endometrial carcinoma and can predict extension of the endometrial carcinoma. Methods Eighty‐four women with uterine bleeding and a...
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| Veröffentlicht in: | Journal of ultrasound in medicine 2007-10, Vol.26 (10), p.1279-1287 |
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| creator | Merce, Luis T Alcazar, Juan L Lopez, Carmen Iglesias, Enrique Bau, Santiago de los Heros, Juan Alvarez Bajo, Jose M |
| description | Objectives
The purpose of this study was to assess whether endometrial volume (EV) and 3‐dimensional (3D) power Doppler indices can discriminate between hyperplasia and endometrial carcinoma and can predict extension of the endometrial carcinoma.
Methods
Eighty‐four women with uterine bleeding and a histopathologic diagnosis of endometrial hyperplasia (n = 29) or carcinoma (n = 55) were preoperatively examined by transvaginal 3D sonography and power Doppler angiography. Endometrial thickness (ET), EV, the vascularization index (VI), the flow index (FI), the vascularization‐flow index (VFI), and the intratumoral resistive index (RI) were measured. A histopathologic diagnosis was made after endometrial biopsy was performed by hysteroscopy or curettage.
Results
The EV and 3D power Doppler indices (VI, FI, and VFI) were significantly higher in endometrial carcinoma than endometrial hyperplasia, whereas the intratumoral RI was significantly lower (P < .05). A VFI of 2.07 was the best cutoff for predicting endometrial carcinoma, with sensitivity of 76.5% and specificity of 80.8%. No significant differences were noticed for ET. The endometrial VI was significantly higher when the tumor stage was greater than I. All the 3D power Doppler indices were significantly higher when the carcinoma infiltrated more than 50% of the myometrium. The intratumoral RI was significantly lower in cases with a high histologic grade, myometrial infiltration of more than 50%, and lymph node metastases.
Conclusions
The VI, 3D power Doppler indices, and the intratumoral RI are more useful than ET for differentiating between hyperplasia and endometrial carcinoma. Intratumoral blood flow evaluated by pulsed Doppler sonography and 3D power Doppler angiography can predict the spread of endometrial carcinoma. |
| doi_str_mv | 10.7863/jum.2007.26.10.1279 |
| format | Article |
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The purpose of this study was to assess whether endometrial volume (EV) and 3‐dimensional (3D) power Doppler indices can discriminate between hyperplasia and endometrial carcinoma and can predict extension of the endometrial carcinoma.
Methods
Eighty‐four women with uterine bleeding and a histopathologic diagnosis of endometrial hyperplasia (n = 29) or carcinoma (n = 55) were preoperatively examined by transvaginal 3D sonography and power Doppler angiography. Endometrial thickness (ET), EV, the vascularization index (VI), the flow index (FI), the vascularization‐flow index (VFI), and the intratumoral resistive index (RI) were measured. A histopathologic diagnosis was made after endometrial biopsy was performed by hysteroscopy or curettage.
Results
The EV and 3D power Doppler indices (VI, FI, and VFI) were significantly higher in endometrial carcinoma than endometrial hyperplasia, whereas the intratumoral RI was significantly lower (P < .05). A VFI of 2.07 was the best cutoff for predicting endometrial carcinoma, with sensitivity of 76.5% and specificity of 80.8%. No significant differences were noticed for ET. The endometrial VI was significantly higher when the tumor stage was greater than I. All the 3D power Doppler indices were significantly higher when the carcinoma infiltrated more than 50% of the myometrium. The intratumoral RI was significantly lower in cases with a high histologic grade, myometrial infiltration of more than 50%, and lymph node metastases.
Conclusions
The VI, 3D power Doppler indices, and the intratumoral RI are more useful than ET for differentiating between hyperplasia and endometrial carcinoma. Intratumoral blood flow evaluated by pulsed Doppler sonography and 3D power Doppler angiography can predict the spread of endometrial carcinoma.</description><identifier>ISSN: 0278-4297</identifier><identifier>EISSN: 1550-9613</identifier><identifier>DOI: 10.7863/jum.2007.26.10.1279</identifier><identifier>PMID: 17901132</identifier><language>eng</language><publisher>England: Am inst Ulrrasound Med</publisher><subject>3-dimensional power Doppler angiography ; 3-dimensional sonography ; Aged ; Carcinoma - blood supply ; Carcinoma - diagnostic imaging ; Carcinoma - pathology ; Chi-Square Distribution ; Diagnosis, Differential ; endometrial carcinoma ; endometrial hyperplasia ; Endometrial Hyperplasia - diagnostic imaging ; Endometrial Hyperplasia - pathology ; Endometrial Neoplasms - blood supply ; Endometrial Neoplasms - diagnostic imaging ; Endometrial Neoplasms - pathology ; endometrial volume ; Female ; Humans ; Image Interpretation, Computer-Assisted ; Imaging, Three-Dimensional ; Middle Aged ; power Doppler angiography ; ROC Curve ; Statistics, Nonparametric ; Ultrasonography - methods ; Ultrasonography, Doppler</subject><ispartof>Journal of ultrasound in medicine, 2007-10, Vol.26 (10), p.1279-1287</ispartof><rights>2016 by the American Institute of Ultrasound in Medicine</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3929-a3145d577ad8985564baf8250f1d3ee3b3e0203be913b85783a3425065e8c1f63</citedby><cites>FETCH-LOGICAL-c3929-a3145d577ad8985564baf8250f1d3ee3b3e0203be913b85783a3425065e8c1f63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.7863%2Fjum.2007.26.10.1279$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.7863%2Fjum.2007.26.10.1279$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17901132$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Merce, Luis T</creatorcontrib><creatorcontrib>Alcazar, Juan L</creatorcontrib><creatorcontrib>Lopez, Carmen</creatorcontrib><creatorcontrib>Iglesias, Enrique</creatorcontrib><creatorcontrib>Bau, Santiago</creatorcontrib><creatorcontrib>de los Heros, Juan Alvarez</creatorcontrib><creatorcontrib>Bajo, Jose M</creatorcontrib><title>Clinical Usefulness of 3-Dimensional Sonography and Power Doppler Angiography for Diagnosis of Endometrial Carcinoma</title><title>Journal of ultrasound in medicine</title><addtitle>J Ultrasound Med</addtitle><description>Objectives
The purpose of this study was to assess whether endometrial volume (EV) and 3‐dimensional (3D) power Doppler indices can discriminate between hyperplasia and endometrial carcinoma and can predict extension of the endometrial carcinoma.
Methods
Eighty‐four women with uterine bleeding and a histopathologic diagnosis of endometrial hyperplasia (n = 29) or carcinoma (n = 55) were preoperatively examined by transvaginal 3D sonography and power Doppler angiography. Endometrial thickness (ET), EV, the vascularization index (VI), the flow index (FI), the vascularization‐flow index (VFI), and the intratumoral resistive index (RI) were measured. A histopathologic diagnosis was made after endometrial biopsy was performed by hysteroscopy or curettage.
Results
The EV and 3D power Doppler indices (VI, FI, and VFI) were significantly higher in endometrial carcinoma than endometrial hyperplasia, whereas the intratumoral RI was significantly lower (P < .05). A VFI of 2.07 was the best cutoff for predicting endometrial carcinoma, with sensitivity of 76.5% and specificity of 80.8%. No significant differences were noticed for ET. The endometrial VI was significantly higher when the tumor stage was greater than I. All the 3D power Doppler indices were significantly higher when the carcinoma infiltrated more than 50% of the myometrium. The intratumoral RI was significantly lower in cases with a high histologic grade, myometrial infiltration of more than 50%, and lymph node metastases.
Conclusions
The VI, 3D power Doppler indices, and the intratumoral RI are more useful than ET for differentiating between hyperplasia and endometrial carcinoma. Intratumoral blood flow evaluated by pulsed Doppler sonography and 3D power Doppler angiography can predict the spread of endometrial carcinoma.</description><subject>3-dimensional power Doppler angiography</subject><subject>3-dimensional sonography</subject><subject>Aged</subject><subject>Carcinoma - blood supply</subject><subject>Carcinoma - diagnostic imaging</subject><subject>Carcinoma - pathology</subject><subject>Chi-Square Distribution</subject><subject>Diagnosis, Differential</subject><subject>endometrial carcinoma</subject><subject>endometrial hyperplasia</subject><subject>Endometrial Hyperplasia - diagnostic imaging</subject><subject>Endometrial Hyperplasia - pathology</subject><subject>Endometrial Neoplasms - blood supply</subject><subject>Endometrial Neoplasms - diagnostic imaging</subject><subject>Endometrial Neoplasms - pathology</subject><subject>endometrial volume</subject><subject>Female</subject><subject>Humans</subject><subject>Image Interpretation, Computer-Assisted</subject><subject>Imaging, Three-Dimensional</subject><subject>Middle Aged</subject><subject>power Doppler angiography</subject><subject>ROC Curve</subject><subject>Statistics, Nonparametric</subject><subject>Ultrasonography - methods</subject><subject>Ultrasonography, Doppler</subject><issn>0278-4297</issn><issn>1550-9613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtv1DAUhS1ERYfCL0BCWcEqgx_xIzuqaXmpVSvBrC0nuZlx5djBniiaf4_DDIIlqyudc-537YPQG4LXUgn24Wka1hRjuaZinTVCZf0MrQjnuKwFYc_RClOpyorW8hK9TOkJY4qJrF6gSyJrTAijK3TYOOtta1yxTdBPzkNKRegLVt7YAXyywWfve_BhF824PxbGd8VjmCEWN2EcXZ7Xfmf_uH3IujU7H5L9zbn1XRjgEG2mbExsrQ-DeYUueuMSvD7PK7T9dPtj86W8e_j8dXN9V7aspnVpGKl4x6U0naoV56JqTK8oxz3pGABrGOQfsQZqwhrFpWKGVdkWHFRLesGu0LsTd4zh5wTpoAebWnDOeAhT0kIxhivMcpCdgm0MKUXo9RjtYOJRE6yXsnUuWy9layoWbSk7b70946dmgO7vzrndHPh4CszWwfF_mPrb9n6RqCD4fOP9CbG3u_1sI-g0GOfyRaLnef7nNb8AzTGcGA</recordid><startdate>200710</startdate><enddate>200710</enddate><creator>Merce, Luis T</creator><creator>Alcazar, Juan L</creator><creator>Lopez, Carmen</creator><creator>Iglesias, Enrique</creator><creator>Bau, Santiago</creator><creator>de los Heros, Juan Alvarez</creator><creator>Bajo, Jose M</creator><general>Am inst Ulrrasound Med</general><general>American Institute of Ultrasound in Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200710</creationdate><title>Clinical Usefulness of 3-Dimensional Sonography and Power Doppler Angiography for Diagnosis of Endometrial Carcinoma</title><author>Merce, Luis T ; Alcazar, Juan L ; Lopez, Carmen ; Iglesias, Enrique ; Bau, Santiago ; de los Heros, Juan Alvarez ; Bajo, Jose M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3929-a3145d577ad8985564baf8250f1d3ee3b3e0203be913b85783a3425065e8c1f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>3-dimensional power Doppler angiography</topic><topic>3-dimensional sonography</topic><topic>Aged</topic><topic>Carcinoma - blood supply</topic><topic>Carcinoma - diagnostic imaging</topic><topic>Carcinoma - pathology</topic><topic>Chi-Square Distribution</topic><topic>Diagnosis, Differential</topic><topic>endometrial carcinoma</topic><topic>endometrial hyperplasia</topic><topic>Endometrial Hyperplasia - diagnostic imaging</topic><topic>Endometrial Hyperplasia - pathology</topic><topic>Endometrial Neoplasms - blood supply</topic><topic>Endometrial Neoplasms - diagnostic imaging</topic><topic>Endometrial Neoplasms - pathology</topic><topic>endometrial volume</topic><topic>Female</topic><topic>Humans</topic><topic>Image Interpretation, Computer-Assisted</topic><topic>Imaging, Three-Dimensional</topic><topic>Middle Aged</topic><topic>power Doppler angiography</topic><topic>ROC Curve</topic><topic>Statistics, Nonparametric</topic><topic>Ultrasonography - methods</topic><topic>Ultrasonography, Doppler</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Merce, Luis T</creatorcontrib><creatorcontrib>Alcazar, Juan L</creatorcontrib><creatorcontrib>Lopez, Carmen</creatorcontrib><creatorcontrib>Iglesias, Enrique</creatorcontrib><creatorcontrib>Bau, Santiago</creatorcontrib><creatorcontrib>de los Heros, Juan Alvarez</creatorcontrib><creatorcontrib>Bajo, Jose M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ultrasound in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Merce, Luis T</au><au>Alcazar, Juan L</au><au>Lopez, Carmen</au><au>Iglesias, Enrique</au><au>Bau, Santiago</au><au>de los Heros, Juan Alvarez</au><au>Bajo, Jose M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical Usefulness of 3-Dimensional Sonography and Power Doppler Angiography for Diagnosis of Endometrial Carcinoma</atitle><jtitle>Journal of ultrasound in medicine</jtitle><addtitle>J Ultrasound Med</addtitle><date>2007-10</date><risdate>2007</risdate><volume>26</volume><issue>10</issue><spage>1279</spage><epage>1287</epage><pages>1279-1287</pages><issn>0278-4297</issn><eissn>1550-9613</eissn><abstract>Objectives
The purpose of this study was to assess whether endometrial volume (EV) and 3‐dimensional (3D) power Doppler indices can discriminate between hyperplasia and endometrial carcinoma and can predict extension of the endometrial carcinoma.
Methods
Eighty‐four women with uterine bleeding and a histopathologic diagnosis of endometrial hyperplasia (n = 29) or carcinoma (n = 55) were preoperatively examined by transvaginal 3D sonography and power Doppler angiography. Endometrial thickness (ET), EV, the vascularization index (VI), the flow index (FI), the vascularization‐flow index (VFI), and the intratumoral resistive index (RI) were measured. A histopathologic diagnosis was made after endometrial biopsy was performed by hysteroscopy or curettage.
Results
The EV and 3D power Doppler indices (VI, FI, and VFI) were significantly higher in endometrial carcinoma than endometrial hyperplasia, whereas the intratumoral RI was significantly lower (P < .05). A VFI of 2.07 was the best cutoff for predicting endometrial carcinoma, with sensitivity of 76.5% and specificity of 80.8%. No significant differences were noticed for ET. The endometrial VI was significantly higher when the tumor stage was greater than I. All the 3D power Doppler indices were significantly higher when the carcinoma infiltrated more than 50% of the myometrium. The intratumoral RI was significantly lower in cases with a high histologic grade, myometrial infiltration of more than 50%, and lymph node metastases.
Conclusions
The VI, 3D power Doppler indices, and the intratumoral RI are more useful than ET for differentiating between hyperplasia and endometrial carcinoma. Intratumoral blood flow evaluated by pulsed Doppler sonography and 3D power Doppler angiography can predict the spread of endometrial carcinoma.</abstract><cop>England</cop><pub>Am inst Ulrrasound Med</pub><pmid>17901132</pmid><doi>10.7863/jum.2007.26.10.1279</doi><tpages>9</tpages></addata></record> |
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| ispartof | Journal of ultrasound in medicine, 2007-10, Vol.26 (10), p.1279-1287 |
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| subjects | 3-dimensional power Doppler angiography 3-dimensional sonography Aged Carcinoma - blood supply Carcinoma - diagnostic imaging Carcinoma - pathology Chi-Square Distribution Diagnosis, Differential endometrial carcinoma endometrial hyperplasia Endometrial Hyperplasia - diagnostic imaging Endometrial Hyperplasia - pathology Endometrial Neoplasms - blood supply Endometrial Neoplasms - diagnostic imaging Endometrial Neoplasms - pathology endometrial volume Female Humans Image Interpretation, Computer-Assisted Imaging, Three-Dimensional Middle Aged power Doppler angiography ROC Curve Statistics, Nonparametric Ultrasonography - methods Ultrasonography, Doppler |
| title | Clinical Usefulness of 3-Dimensional Sonography and Power Doppler Angiography for Diagnosis of Endometrial Carcinoma |
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