Neonatal Hind-Paw Injury Disrupts Acquisition of an Instrumental Response in Adult Spinal Rats
The present study was designed to evaluate the impact of neonatal injury on adult spinal plasticity in rats. Subjects were randomly assigned to 1 of 4 experimental conditions: (a) hind-paw injury at Postnatal Day (PD) 2, (b) hind-paw injury at PD 5, (c) anesthesia exposure only on PD 2, or (d) anest...
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| Veröffentlicht in: | Behavioral neuroscience 2007-10, Vol.121 (5), p.1095-1100 |
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| creator | Young, Erin E Baumbauer, Kyle M Elliot, Audrea Joynes, Robin L |
| description | The present study was designed to evaluate the impact of neonatal injury on adult spinal plasticity in rats. Subjects were randomly assigned to 1 of 4 experimental conditions: (a) hind-paw injury at Postnatal Day (PD) 2, (b) hind-paw injury at PD 5, (c) anesthesia exposure only on PD 2, or (d) anesthesia exposure only on PD 5. Subjects receiving a unilateral neonatal hind-paw injury showed decreased mechanical threshold (hyperalgesia) on the previously injured hind paw throughout development. This decrease in threshold survived spinal transection (at T2) at 12 weeks of age. Injured subjects also showed significant impairment in a spinal instrumental learning task performed by the previously injured hind paw. This disruption of learning indicates a disruption of spinal plasticity that may be due to induction of long-term changes in nociceptive processing within the spinal cord. |
| doi_str_mv | 10.1037/0735-7044.121.5.1095 |
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Subjects were randomly assigned to 1 of 4 experimental conditions: (a) hind-paw injury at Postnatal Day (PD) 2, (b) hind-paw injury at PD 5, (c) anesthesia exposure only on PD 2, or (d) anesthesia exposure only on PD 5. Subjects receiving a unilateral neonatal hind-paw injury showed decreased mechanical threshold (hyperalgesia) on the previously injured hind paw throughout development. This decrease in threshold survived spinal transection (at T2) at 12 weeks of age. Injured subjects also showed significant impairment in a spinal instrumental learning task performed by the previously injured hind paw. This disruption of learning indicates a disruption of spinal plasticity that may be due to induction of long-term changes in nociceptive processing within the spinal cord.</description><identifier>ISSN: 0735-7044</identifier><identifier>EISSN: 1939-0084</identifier><identifier>DOI: 10.1037/0735-7044.121.5.1095</identifier><identifier>PMID: 17907840</identifier><identifier>CODEN: BENEDJ</identifier><language>eng</language><publisher>Washington, DC: American Psychological Association</publisher><subject>Aging - physiology ; Anesthesia ; Animal ; Animal Limb ; Animals ; Animals, Newborn - physiology ; Behavioral psychophysiology ; Biological and medical sciences ; Conditioning, Operant - physiology ; Decerebrate State - psychology ; Electroshock ; Female ; Foot Injuries - psychology ; Fundamental and applied biological sciences. Psychology ; Hindlimb - injuries ; Hyperalgesia - physiopathology ; Injuries ; Male ; Neonatal Period ; Neural Plasticity ; Neurology ; Neuronal Plasticity - physiology ; Neuropsychology ; Pain - physiopathology ; Pain Measurement ; Pain Perception ; Pain Threshold - physiology ; Physical Stimulation ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Rats ; Rats, Sprague-Dawley ; Rodents ; Spinal Cord ; Thresholds</subject><ispartof>Behavioral neuroscience, 2007-10, Vol.121 (5), p.1095-1100</ispartof><rights>2007 American Psychological Association</rights><rights>2007 INIST-CNRS</rights><rights>(PsycINFO Database Record (c) 2007 APA, all rights reserved).</rights><rights>Copyright American Psychological Association Oct 2007</rights><rights>2007, American Psychological Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a458t-3153e94f3a63966d4fb490f055c815b44e7383201a017acf659c4b31d06319483</citedby><orcidid>0000-0003-0437-9209 ; 0000-0001-7623-280X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19136577$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17907840$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Disterhoft, John F</contributor><creatorcontrib>Young, Erin E</creatorcontrib><creatorcontrib>Baumbauer, Kyle M</creatorcontrib><creatorcontrib>Elliot, Audrea</creatorcontrib><creatorcontrib>Joynes, Robin L</creatorcontrib><title>Neonatal Hind-Paw Injury Disrupts Acquisition of an Instrumental Response in Adult Spinal Rats</title><title>Behavioral neuroscience</title><addtitle>Behav Neurosci</addtitle><description>The present study was designed to evaluate the impact of neonatal injury on adult spinal plasticity in rats. Subjects were randomly assigned to 1 of 4 experimental conditions: (a) hind-paw injury at Postnatal Day (PD) 2, (b) hind-paw injury at PD 5, (c) anesthesia exposure only on PD 2, or (d) anesthesia exposure only on PD 5. Subjects receiving a unilateral neonatal hind-paw injury showed decreased mechanical threshold (hyperalgesia) on the previously injured hind paw throughout development. This decrease in threshold survived spinal transection (at T2) at 12 weeks of age. Injured subjects also showed significant impairment in a spinal instrumental learning task performed by the previously injured hind paw. This disruption of learning indicates a disruption of spinal plasticity that may be due to induction of long-term changes in nociceptive processing within the spinal cord.</description><subject>Aging - physiology</subject><subject>Anesthesia</subject><subject>Animal</subject><subject>Animal Limb</subject><subject>Animals</subject><subject>Animals, Newborn - physiology</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Conditioning, Operant - physiology</subject><subject>Decerebrate State - psychology</subject><subject>Electroshock</subject><subject>Female</subject><subject>Foot Injuries - psychology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hindlimb - injuries</subject><subject>Hyperalgesia - physiopathology</subject><subject>Injuries</subject><subject>Male</subject><subject>Neonatal Period</subject><subject>Neural Plasticity</subject><subject>Neurology</subject><subject>Neuronal Plasticity - physiology</subject><subject>Neuropsychology</subject><subject>Pain - physiopathology</subject><subject>Pain Measurement</subject><subject>Pain Perception</subject><subject>Pain Threshold - physiology</subject><subject>Physical Stimulation</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Rodents</subject><subject>Spinal Cord</subject><subject>Thresholds</subject><issn>0735-7044</issn><issn>1939-0084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90ctq3DAUBmBRWppJ2jcoxRSanSdH1sXWckibJhCa0su2QpZl0OCRHR2LMm9fmRkaGkJWAun7JXF-Qt5RWFNg9QXUTJQ1cL6mFV2LvKnEC7KiiqkSoOEvyeofOSGniFsA4MDFa3JCawV1w2FFfn91YzCzGYprH7rym_lT3IRtivvik8eYphmLjb1PHv3sx1CMfWFCFjjHtHNhyX13OI0BXeFDsenSMBc_Jh-WAzPjG_KqNwO6t8f1jPy6-vzz8rq8vftyc7m5LQ0XzVwyKphTvGdGMiVlx_uWK-hBCNtQ0XLuatawCqgBWhvbS6EsbxntQDKqeMPOyPnh3imO98nhrHcerRsGE9yYUMucVqoSGX54BLdjivm72VDOG6jks6gC1uTBSZ4RPyAbR8Toej1FvzNxrynopSG9jF8v49e5IS300lCOvT_endqd6x5Cx0oy-HgEBq0Z-miC9fjgFGVS1HV25cGZyegJ99bE2dvBoU0x5mp0G9z_D58_7R_Dv9dBsss</recordid><startdate>20071001</startdate><enddate>20071001</enddate><creator>Young, Erin E</creator><creator>Baumbauer, Kyle M</creator><creator>Elliot, Audrea</creator><creator>Joynes, Robin L</creator><general>American Psychological Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7RZ</scope><scope>PSYQQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0437-9209</orcidid><orcidid>https://orcid.org/0000-0001-7623-280X</orcidid></search><sort><creationdate>20071001</creationdate><title>Neonatal Hind-Paw Injury Disrupts Acquisition of an Instrumental Response in Adult Spinal Rats</title><author>Young, Erin E ; Baumbauer, Kyle M ; Elliot, Audrea ; Joynes, Robin L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a458t-3153e94f3a63966d4fb490f055c815b44e7383201a017acf659c4b31d06319483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Aging - physiology</topic><topic>Anesthesia</topic><topic>Animal</topic><topic>Animal Limb</topic><topic>Animals</topic><topic>Animals, Newborn - physiology</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Conditioning, Operant - physiology</topic><topic>Decerebrate State - psychology</topic><topic>Electroshock</topic><topic>Female</topic><topic>Foot Injuries - psychology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hindlimb - injuries</topic><topic>Hyperalgesia - physiopathology</topic><topic>Injuries</topic><topic>Male</topic><topic>Neonatal Period</topic><topic>Neural Plasticity</topic><topic>Neurology</topic><topic>Neuronal Plasticity - physiology</topic><topic>Neuropsychology</topic><topic>Pain - physiopathology</topic><topic>Pain Measurement</topic><topic>Pain Perception</topic><topic>Pain Threshold - physiology</topic><topic>Physical Stimulation</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Rodents</topic><topic>Spinal Cord</topic><topic>Thresholds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Young, Erin E</creatorcontrib><creatorcontrib>Baumbauer, Kyle M</creatorcontrib><creatorcontrib>Elliot, Audrea</creatorcontrib><creatorcontrib>Joynes, Robin L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>APA PsycArticles®</collection><collection>ProQuest One Psychology</collection><collection>MEDLINE - Academic</collection><jtitle>Behavioral neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Young, Erin E</au><au>Baumbauer, Kyle M</au><au>Elliot, Audrea</au><au>Joynes, Robin L</au><au>Disterhoft, John F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neonatal Hind-Paw Injury Disrupts Acquisition of an Instrumental Response in Adult Spinal Rats</atitle><jtitle>Behavioral neuroscience</jtitle><addtitle>Behav Neurosci</addtitle><date>2007-10-01</date><risdate>2007</risdate><volume>121</volume><issue>5</issue><spage>1095</spage><epage>1100</epage><pages>1095-1100</pages><issn>0735-7044</issn><eissn>1939-0084</eissn><coden>BENEDJ</coden><abstract>The present study was designed to evaluate the impact of neonatal injury on adult spinal plasticity in rats. Subjects were randomly assigned to 1 of 4 experimental conditions: (a) hind-paw injury at Postnatal Day (PD) 2, (b) hind-paw injury at PD 5, (c) anesthesia exposure only on PD 2, or (d) anesthesia exposure only on PD 5. Subjects receiving a unilateral neonatal hind-paw injury showed decreased mechanical threshold (hyperalgesia) on the previously injured hind paw throughout development. This decrease in threshold survived spinal transection (at T2) at 12 weeks of age. Injured subjects also showed significant impairment in a spinal instrumental learning task performed by the previously injured hind paw. This disruption of learning indicates a disruption of spinal plasticity that may be due to induction of long-term changes in nociceptive processing within the spinal cord.</abstract><cop>Washington, DC</cop><pub>American Psychological Association</pub><pmid>17907840</pmid><doi>10.1037/0735-7044.121.5.1095</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-0437-9209</orcidid><orcidid>https://orcid.org/0000-0001-7623-280X</orcidid></addata></record> |
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| subjects | Aging - physiology Anesthesia Animal Animal Limb Animals Animals, Newborn - physiology Behavioral psychophysiology Biological and medical sciences Conditioning, Operant - physiology Decerebrate State - psychology Electroshock Female Foot Injuries - psychology Fundamental and applied biological sciences. Psychology Hindlimb - injuries Hyperalgesia - physiopathology Injuries Male Neonatal Period Neural Plasticity Neurology Neuronal Plasticity - physiology Neuropsychology Pain - physiopathology Pain Measurement Pain Perception Pain Threshold - physiology Physical Stimulation Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Sprague-Dawley Rodents Spinal Cord Thresholds |
| title | Neonatal Hind-Paw Injury Disrupts Acquisition of an Instrumental Response in Adult Spinal Rats |
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