Evaluation of insulin resistance in Turkish girls with premature pubarche using the homeostasis assessment (HOMA) model
Premature pubarche can be benign, or it can be an early marker of insulin resistance in some girls. The aim of this study was to evaluate insulin resistance in prepubertal girls presenting with premature pubarche (n = 19; mean age = 6.93 +/- 1.78) as compared to age- and Tanner stage-matched control...
Gespeichert in:
| Veröffentlicht in: | Turkish journal of pediatrics 2007-04, Vol.49 (2), p.165-170 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 170 |
|---|---|
| container_issue | 2 |
| container_start_page | 165 |
| container_title | Turkish journal of pediatrics |
| container_volume | 49 |
| creator | Evliyaoğlu, Olcay Berberoğlu, Merih Adiyaman, Pelin Aycan, Zehra Ocal, Gönül |
| description | Premature pubarche can be benign, or it can be an early marker of insulin resistance in some girls. The aim of this study was to evaluate insulin resistance in prepubertal girls presenting with premature pubarche (n = 19; mean age = 6.93 +/- 1.78) as compared to age- and Tanner stage-matched controls (n = 10; mean age = 7.55 +/- 1.32) using indirect insulin resistance parameters. Two groups were compared by means of oral glucose tolerance test (OGTT), indirect insulin resistance (IR) parameters [homeostasis assessment (HOMA) models: HOMA-IR, glucose/insulin (G/I)] and serum lipid profiles. In the girls with premature pubarche, mean baseline insulin level and HOMA-IR value were significantly higher and G/I ratio was lower than in the control group. IR was observed in 42.1% and in 31.6% according to HOMA-IR value and G/I ratio, respectively. Even at diagnosis, IR was increased in a significant portion of the girls with premature pubarche. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_68328978</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1336846921</sourcerecordid><originalsourceid>FETCH-LOGICAL-p236t-5bfa5ae6285f7c5107b868a1a4033e4f984e8be1dac96dd3ba851fe7ae6f15103</originalsourceid><addsrcrecordid>eNpdkM1OwzAQhHMA0VJ4BWRxQHCIZMdJ7ByrqvxIRb2Uc-Qkm8YlcYLXpuLtMaJcOO1o9c1oNGfRnNKUxSmnbBZdIh4oTQQtxEU0Y6KgImP5PDquP1XvldOjIWNLtEHfa0MsoEanTA3hRXbevmvsyF7bHslRu45MFgblvAUy-UrZugPiUZs9cUF14wBjsIcMohABcQDjyP3z9nX5QIaxgf4qOm9Vj3B9uovo7XG9Wz3Hm-3Ty2q5iaeE5y7OqlZlCvJEZq2oM0ZFJXOpmEop55C2hUxBVsAaVRd50_BKyYy1IIKlZQHni-juN3ey44cHdOWgsYa-VwZGj2UueSILIQN4-w88jN6a0K1MWM4pL5If6OYE-WqAppysHpT9Kv_25N8b8XJl</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>216303928</pqid></control><display><type>article</type><title>Evaluation of insulin resistance in Turkish girls with premature pubarche using the homeostasis assessment (HOMA) model</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Evliyaoğlu, Olcay ; Berberoğlu, Merih ; Adiyaman, Pelin ; Aycan, Zehra ; Ocal, Gönül</creator><creatorcontrib>Evliyaoğlu, Olcay ; Berberoğlu, Merih ; Adiyaman, Pelin ; Aycan, Zehra ; Ocal, Gönül</creatorcontrib><description>Premature pubarche can be benign, or it can be an early marker of insulin resistance in some girls. The aim of this study was to evaluate insulin resistance in prepubertal girls presenting with premature pubarche (n = 19; mean age = 6.93 +/- 1.78) as compared to age- and Tanner stage-matched controls (n = 10; mean age = 7.55 +/- 1.32) using indirect insulin resistance parameters. Two groups were compared by means of oral glucose tolerance test (OGTT), indirect insulin resistance (IR) parameters [homeostasis assessment (HOMA) models: HOMA-IR, glucose/insulin (G/I)] and serum lipid profiles. In the girls with premature pubarche, mean baseline insulin level and HOMA-IR value were significantly higher and G/I ratio was lower than in the control group. IR was observed in 42.1% and in 31.6% according to HOMA-IR value and G/I ratio, respectively. Even at diagnosis, IR was increased in a significant portion of the girls with premature pubarche.</description><identifier>ISSN: 0041-4301</identifier><identifier>PMID: 17907516</identifier><language>eng</language><publisher>Turkey: Hacettepe University Faculty of Medicine</publisher><subject>Case-Control Studies ; Child ; Female ; Glucose Tolerance Test ; Homeostasis ; Hormones - blood ; Humans ; Insulin - blood ; Insulin Resistance ; Lipids - blood ; Puberty, Precocious - blood ; Statistics, Nonparametric ; Turkey</subject><ispartof>Turkish journal of pediatrics, 2007-04, Vol.49 (2), p.165-170</ispartof><rights>Copyright Hacettepe University Faculty of Medicine Apr-Jun 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17907516$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Evliyaoğlu, Olcay</creatorcontrib><creatorcontrib>Berberoğlu, Merih</creatorcontrib><creatorcontrib>Adiyaman, Pelin</creatorcontrib><creatorcontrib>Aycan, Zehra</creatorcontrib><creatorcontrib>Ocal, Gönül</creatorcontrib><title>Evaluation of insulin resistance in Turkish girls with premature pubarche using the homeostasis assessment (HOMA) model</title><title>Turkish journal of pediatrics</title><addtitle>Turk J Pediatr</addtitle><description>Premature pubarche can be benign, or it can be an early marker of insulin resistance in some girls. The aim of this study was to evaluate insulin resistance in prepubertal girls presenting with premature pubarche (n = 19; mean age = 6.93 +/- 1.78) as compared to age- and Tanner stage-matched controls (n = 10; mean age = 7.55 +/- 1.32) using indirect insulin resistance parameters. Two groups were compared by means of oral glucose tolerance test (OGTT), indirect insulin resistance (IR) parameters [homeostasis assessment (HOMA) models: HOMA-IR, glucose/insulin (G/I)] and serum lipid profiles. In the girls with premature pubarche, mean baseline insulin level and HOMA-IR value were significantly higher and G/I ratio was lower than in the control group. IR was observed in 42.1% and in 31.6% according to HOMA-IR value and G/I ratio, respectively. Even at diagnosis, IR was increased in a significant portion of the girls with premature pubarche.</description><subject>Case-Control Studies</subject><subject>Child</subject><subject>Female</subject><subject>Glucose Tolerance Test</subject><subject>Homeostasis</subject><subject>Hormones - blood</subject><subject>Humans</subject><subject>Insulin - blood</subject><subject>Insulin Resistance</subject><subject>Lipids - blood</subject><subject>Puberty, Precocious - blood</subject><subject>Statistics, Nonparametric</subject><subject>Turkey</subject><issn>0041-4301</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkM1OwzAQhHMA0VJ4BWRxQHCIZMdJ7ByrqvxIRb2Uc-Qkm8YlcYLXpuLtMaJcOO1o9c1oNGfRnNKUxSmnbBZdIh4oTQQtxEU0Y6KgImP5PDquP1XvldOjIWNLtEHfa0MsoEanTA3hRXbevmvsyF7bHslRu45MFgblvAUy-UrZugPiUZs9cUF14wBjsIcMohABcQDjyP3z9nX5QIaxgf4qOm9Vj3B9uovo7XG9Wz3Hm-3Ty2q5iaeE5y7OqlZlCvJEZq2oM0ZFJXOpmEop55C2hUxBVsAaVRd50_BKyYy1IIKlZQHni-juN3ey44cHdOWgsYa-VwZGj2UueSILIQN4-w88jN6a0K1MWM4pL5If6OYE-WqAppysHpT9Kv_25N8b8XJl</recordid><startdate>20070401</startdate><enddate>20070401</enddate><creator>Evliyaoğlu, Olcay</creator><creator>Berberoğlu, Merih</creator><creator>Adiyaman, Pelin</creator><creator>Aycan, Zehra</creator><creator>Ocal, Gönül</creator><general>Hacettepe University Faculty of Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>4T-</scope><scope>4U-</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>EDSIH</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20070401</creationdate><title>Evaluation of insulin resistance in Turkish girls with premature pubarche using the homeostasis assessment (HOMA) model</title><author>Evliyaoğlu, Olcay ; Berberoğlu, Merih ; Adiyaman, Pelin ; Aycan, Zehra ; Ocal, Gönül</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p236t-5bfa5ae6285f7c5107b868a1a4033e4f984e8be1dac96dd3ba851fe7ae6f15103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Case-Control Studies</topic><topic>Child</topic><topic>Female</topic><topic>Glucose Tolerance Test</topic><topic>Homeostasis</topic><topic>Hormones - blood</topic><topic>Humans</topic><topic>Insulin - blood</topic><topic>Insulin Resistance</topic><topic>Lipids - blood</topic><topic>Puberty, Precocious - blood</topic><topic>Statistics, Nonparametric</topic><topic>Turkey</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Evliyaoğlu, Olcay</creatorcontrib><creatorcontrib>Berberoğlu, Merih</creatorcontrib><creatorcontrib>Adiyaman, Pelin</creatorcontrib><creatorcontrib>Aycan, Zehra</creatorcontrib><creatorcontrib>Ocal, Gönül</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>University Readers</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Turkey Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Turkish journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Evliyaoğlu, Olcay</au><au>Berberoğlu, Merih</au><au>Adiyaman, Pelin</au><au>Aycan, Zehra</au><au>Ocal, Gönül</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of insulin resistance in Turkish girls with premature pubarche using the homeostasis assessment (HOMA) model</atitle><jtitle>Turkish journal of pediatrics</jtitle><addtitle>Turk J Pediatr</addtitle><date>2007-04-01</date><risdate>2007</risdate><volume>49</volume><issue>2</issue><spage>165</spage><epage>170</epage><pages>165-170</pages><issn>0041-4301</issn><abstract>Premature pubarche can be benign, or it can be an early marker of insulin resistance in some girls. The aim of this study was to evaluate insulin resistance in prepubertal girls presenting with premature pubarche (n = 19; mean age = 6.93 +/- 1.78) as compared to age- and Tanner stage-matched controls (n = 10; mean age = 7.55 +/- 1.32) using indirect insulin resistance parameters. Two groups were compared by means of oral glucose tolerance test (OGTT), indirect insulin resistance (IR) parameters [homeostasis assessment (HOMA) models: HOMA-IR, glucose/insulin (G/I)] and serum lipid profiles. In the girls with premature pubarche, mean baseline insulin level and HOMA-IR value were significantly higher and G/I ratio was lower than in the control group. IR was observed in 42.1% and in 31.6% according to HOMA-IR value and G/I ratio, respectively. Even at diagnosis, IR was increased in a significant portion of the girls with premature pubarche.</abstract><cop>Turkey</cop><pub>Hacettepe University Faculty of Medicine</pub><pmid>17907516</pmid><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0041-4301 |
| ispartof | Turkish journal of pediatrics, 2007-04, Vol.49 (2), p.165-170 |
| issn | 0041-4301 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68328978 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Case-Control Studies Child Female Glucose Tolerance Test Homeostasis Hormones - blood Humans Insulin - blood Insulin Resistance Lipids - blood Puberty, Precocious - blood Statistics, Nonparametric Turkey |
| title | Evaluation of insulin resistance in Turkish girls with premature pubarche using the homeostasis assessment (HOMA) model |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T11%3A44%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evaluation%20of%20insulin%20resistance%20in%20Turkish%20girls%20with%20premature%20pubarche%20using%20the%20homeostasis%20assessment%20(HOMA)%20model&rft.jtitle=Turkish%20journal%20of%20pediatrics&rft.au=Evliyao%C4%9Flu,%20Olcay&rft.date=2007-04-01&rft.volume=49&rft.issue=2&rft.spage=165&rft.epage=170&rft.pages=165-170&rft.issn=0041-4301&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E1336846921%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=216303928&rft_id=info:pmid/17907516&rfr_iscdi=true |