Intravenously transplanted human neural stem cells migrate to the injured spinal cord in adult mice in an SDF-1- and HGF-dependent manner

Neural stem cell (NSC) transplantation has exhibited considerable therapeutic potential in spinal cord injury. However, most experiments in animals have been performed by injecting these cells directly into the injured spinal cord. A cardinal feature of NSCs is their exceptional migratory ability th...

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Veröffentlicht in:	Neuroscience letters 2007-10, Vol.426 (2), p.69-74
Hauptverfasser:	Takeuchi, Hiroki, Natsume, Atsushi, Wakabayashi, Toshihiko, Aoshima, Chihiro, Shimato, Shinji, Ito, Motokazu, Ishii, Jun, Maeda, Yuka, Hara, Masahito, Kim, Seung U., Yoshida, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids Animals Behavior, Animal Biological and medical sciences Cell Movement - physiology Chemokine CXCL12 - metabolism Disease Models, Animal Fetus Fundamental and applied biological sciences. Psychology Hepatocyte Growth Factor - metabolism HGF Humans Injections, Intravenous - methods Intravenous delivery Mice Motor Activity - physiology Neural stem cells Neurons - physiology SDF-1 Spinal Cord Injuries - physiopathology Spinal Cord Injuries - surgery Spinal cord injury Stem Cell Transplantation - methods Stem Cells - physiology Time Factors Transplantation, Heterologous - methods Vertebrates: nervous system and sense organs
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