Using Magnetic Force to Enhance Immune Response to DNA Vaccine
The improvement of the gene distribution within skeletal muscle to enhance the immunogenicity of DNA vaccines is reported. Magnetic force acting on DNA vaccine associated with magnetic nanoparticles (see image), the major potential of which lies in extraordinarily rapid and efficient transfection at...
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| Veröffentlicht in: | Small (Weinheim an der Bergstrasse, Germany) Germany), 2007-10, Vol.3 (10), p.1707-1713 |
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| container_issue | 10 |
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| container_title | Small (Weinheim an der Bergstrasse, Germany) |
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| creator | Zhou, Xian-Feng Liu, Bin Yu, Xiang-Hui Zha, Xiao Zhang, Xi-Zhen Wang, Xue-Yun Jin, Ying-Hua Wu, Yong-Ge Jiang, Chun-Lai Chen, Yue Chen, Yan Shan, Ya-Ming Liu, Jun-Qiu Kong, Wei Shen, Jia-Cong |
| description | The improvement of the gene distribution within skeletal muscle to enhance the immunogenicity of DNA vaccines is reported. Magnetic force acting on DNA vaccine associated with magnetic nanoparticles (see image), the major potential of which lies in extraordinarily rapid and efficient transfection at low vector doses, is utilized. After immunization, the magnetic DNA vector induces significantly enhanced serum antibody responses 2–3 orders of magnitude greater than naked DNA. |
| doi_str_mv | 10.1002/smll.200700151 |
| format | Article |
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Magnetic force acting on DNA vaccine associated with magnetic nanoparticles (see image), the major potential of which lies in extraordinarily rapid and efficient transfection at low vector doses, is utilized. After immunization, the magnetic DNA vector induces significantly enhanced serum antibody responses 2–3 orders of magnitude greater than naked DNA.</description><identifier>ISSN: 1613-6810</identifier><identifier>EISSN: 1613-6829</identifier><identifier>DOI: 10.1002/smll.200700151</identifier><identifier>PMID: 17853496</identifier><language>eng</language><publisher>Weinheim: WILEY-VCH Verlag</publisher><subject>Animals ; Cercopithecus aethiops ; COS Cells ; DNA ; drug delivery ; immunogenicity ; magnetic nanoparticles ; Magnetics ; Mice ; Mice, Inbred BALB C ; Microscopy, Electron, Transmission ; Muscle, Skeletal - cytology ; Nanoparticles - chemistry ; Transfection ; vaccines ; Vaccines, DNA - immunology</subject><ispartof>Small (Weinheim an der Bergstrasse, Germany), 2007-10, Vol.3 (10), p.1707-1713</ispartof><rights>Copyright © 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4121-d39acdf2f520a6660b281484e0f2da904fa794ab2b28a5cbb5057edd4941491a3</citedby><cites>FETCH-LOGICAL-c4121-d39acdf2f520a6660b281484e0f2da904fa794ab2b28a5cbb5057edd4941491a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fsmll.200700151$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fsmll.200700151$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17853496$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, Xian-Feng</creatorcontrib><creatorcontrib>Liu, Bin</creatorcontrib><creatorcontrib>Yu, Xiang-Hui</creatorcontrib><creatorcontrib>Zha, Xiao</creatorcontrib><creatorcontrib>Zhang, Xi-Zhen</creatorcontrib><creatorcontrib>Wang, Xue-Yun</creatorcontrib><creatorcontrib>Jin, Ying-Hua</creatorcontrib><creatorcontrib>Wu, Yong-Ge</creatorcontrib><creatorcontrib>Jiang, Chun-Lai</creatorcontrib><creatorcontrib>Chen, Yue</creatorcontrib><creatorcontrib>Chen, Yan</creatorcontrib><creatorcontrib>Shan, Ya-Ming</creatorcontrib><creatorcontrib>Liu, Jun-Qiu</creatorcontrib><creatorcontrib>Kong, Wei</creatorcontrib><creatorcontrib>Shen, Jia-Cong</creatorcontrib><title>Using Magnetic Force to Enhance Immune Response to DNA Vaccine</title><title>Small (Weinheim an der Bergstrasse, Germany)</title><addtitle>Small</addtitle><description>The improvement of the gene distribution within skeletal muscle to enhance the immunogenicity of DNA vaccines is reported. Magnetic force acting on DNA vaccine associated with magnetic nanoparticles (see image), the major potential of which lies in extraordinarily rapid and efficient transfection at low vector doses, is utilized. After immunization, the magnetic DNA vector induces significantly enhanced serum antibody responses 2–3 orders of magnitude greater than naked DNA.</description><subject>Animals</subject><subject>Cercopithecus aethiops</subject><subject>COS Cells</subject><subject>DNA</subject><subject>drug delivery</subject><subject>immunogenicity</subject><subject>magnetic nanoparticles</subject><subject>Magnetics</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Microscopy, Electron, Transmission</subject><subject>Muscle, Skeletal - cytology</subject><subject>Nanoparticles - chemistry</subject><subject>Transfection</subject><subject>vaccines</subject><subject>Vaccines, DNA - immunology</subject><issn>1613-6810</issn><issn>1613-6829</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkD1PwzAQhi0EolBYGVEmtpQ724mTBamCfkltKR8FNstxnBLIR4lbQf89Ka0KG9Od7p73HR5CzhBaCEAvbZ5lLQogANDDPXKEPjLXD2i4v9sRGuTY2jcAhpSLQ9JAEXiMh_4RuZratJg5IzUrzCLVTrestHEWpdMpXlVRr4M8XxbGuTd2Xhb253UzbjtPSuu0MCfkIFGZNafb2STTbufxuu8Ob3uD6_bQ1RwpujELlY4TmngUlO_7ENEAecANJDRWIfBEiZCriNZ35eko8sATJo55yJGHqFiTXGx651X5sTR2IfPUapNlqjDl0ko_YDQQXPwLMkBWawlqsLUBdVVaW5lEzqs0V9VKIsi1WrlWK3dq68D5tnkZ5Sb-xbcuayDcAJ9pZlb_1MmH0XD4t9zdZFO7MF-7rKrepS-Y8OTzuCfpCMeTyUtf3rFvxIyS1g</recordid><startdate>20071001</startdate><enddate>20071001</enddate><creator>Zhou, Xian-Feng</creator><creator>Liu, Bin</creator><creator>Yu, Xiang-Hui</creator><creator>Zha, Xiao</creator><creator>Zhang, Xi-Zhen</creator><creator>Wang, Xue-Yun</creator><creator>Jin, Ying-Hua</creator><creator>Wu, Yong-Ge</creator><creator>Jiang, Chun-Lai</creator><creator>Chen, Yue</creator><creator>Chen, Yan</creator><creator>Shan, Ya-Ming</creator><creator>Liu, Jun-Qiu</creator><creator>Kong, Wei</creator><creator>Shen, Jia-Cong</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>20071001</creationdate><title>Using Magnetic Force to Enhance Immune Response to DNA Vaccine</title><author>Zhou, Xian-Feng ; Liu, Bin ; Yu, Xiang-Hui ; Zha, Xiao ; Zhang, Xi-Zhen ; Wang, Xue-Yun ; Jin, Ying-Hua ; Wu, Yong-Ge ; Jiang, Chun-Lai ; Chen, Yue ; Chen, Yan ; Shan, Ya-Ming ; Liu, Jun-Qiu ; Kong, Wei ; Shen, Jia-Cong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4121-d39acdf2f520a6660b281484e0f2da904fa794ab2b28a5cbb5057edd4941491a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Cercopithecus aethiops</topic><topic>COS Cells</topic><topic>DNA</topic><topic>drug delivery</topic><topic>immunogenicity</topic><topic>magnetic nanoparticles</topic><topic>Magnetics</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Microscopy, Electron, Transmission</topic><topic>Muscle, Skeletal - cytology</topic><topic>Nanoparticles - chemistry</topic><topic>Transfection</topic><topic>vaccines</topic><topic>Vaccines, DNA - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhou, Xian-Feng</creatorcontrib><creatorcontrib>Liu, Bin</creatorcontrib><creatorcontrib>Yu, Xiang-Hui</creatorcontrib><creatorcontrib>Zha, Xiao</creatorcontrib><creatorcontrib>Zhang, Xi-Zhen</creatorcontrib><creatorcontrib>Wang, Xue-Yun</creatorcontrib><creatorcontrib>Jin, Ying-Hua</creatorcontrib><creatorcontrib>Wu, Yong-Ge</creatorcontrib><creatorcontrib>Jiang, Chun-Lai</creatorcontrib><creatorcontrib>Chen, Yue</creatorcontrib><creatorcontrib>Chen, Yan</creatorcontrib><creatorcontrib>Shan, Ya-Ming</creatorcontrib><creatorcontrib>Liu, Jun-Qiu</creatorcontrib><creatorcontrib>Kong, Wei</creatorcontrib><creatorcontrib>Shen, Jia-Cong</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Small (Weinheim an der Bergstrasse, Germany)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Xian-Feng</au><au>Liu, Bin</au><au>Yu, Xiang-Hui</au><au>Zha, Xiao</au><au>Zhang, Xi-Zhen</au><au>Wang, Xue-Yun</au><au>Jin, Ying-Hua</au><au>Wu, Yong-Ge</au><au>Jiang, Chun-Lai</au><au>Chen, Yue</au><au>Chen, Yan</au><au>Shan, Ya-Ming</au><au>Liu, Jun-Qiu</au><au>Kong, Wei</au><au>Shen, Jia-Cong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Using Magnetic Force to Enhance Immune Response to DNA Vaccine</atitle><jtitle>Small (Weinheim an der Bergstrasse, Germany)</jtitle><addtitle>Small</addtitle><date>2007-10-01</date><risdate>2007</risdate><volume>3</volume><issue>10</issue><spage>1707</spage><epage>1713</epage><pages>1707-1713</pages><issn>1613-6810</issn><eissn>1613-6829</eissn><abstract>The improvement of the gene distribution within skeletal muscle to enhance the immunogenicity of DNA vaccines is reported. Magnetic force acting on DNA vaccine associated with magnetic nanoparticles (see image), the major potential of which lies in extraordinarily rapid and efficient transfection at low vector doses, is utilized. After immunization, the magnetic DNA vector induces significantly enhanced serum antibody responses 2–3 orders of magnitude greater than naked DNA.</abstract><cop>Weinheim</cop><pub>WILEY-VCH Verlag</pub><pmid>17853496</pmid><doi>10.1002/smll.200700151</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Cercopithecus aethiops COS Cells DNA drug delivery immunogenicity magnetic nanoparticles Magnetics Mice Mice, Inbred BALB C Microscopy, Electron, Transmission Muscle, Skeletal - cytology Nanoparticles - chemistry Transfection vaccines Vaccines, DNA - immunology |
| title | Using Magnetic Force to Enhance Immune Response to DNA Vaccine |
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