Studies of long-term noopept and afobazol treatment in rats with learned helplessness neurosis
Long-lasting effects of new Russian psychotropic drugs Noopept and Afobazol on active avoidance conditioning and formation of learned helplessness neurosis were studied on an original experimental model in rats. Noopept eliminated the manifestations of learned helplessness after long-term (21-day) t...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2006-08, Vol.142 (2), p.202-204 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Uyanaev, A A Fisenko, V P |
| description | Long-lasting effects of new Russian psychotropic drugs Noopept and Afobazol on active avoidance conditioning and formation of learned helplessness neurosis were studied on an original experimental model in rats. Noopept eliminated the manifestations of learned helplessness after long-term (21-day) treatment by increasing the percent of trained animals. Afobazol was low effective in preventing manifestations of learned helplessness, but if used for a long time, it reduced the incidence of learned helplessness development by increasing the percent of untrained animals. |
| doi_str_mv | 10.1007/s10517-006-0327-5 |
| format | Article |
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| ispartof | Bulletin of experimental biology and medicine, 2006-08, Vol.142 (2), p.202-204 |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Avoidance Learning - drug effects Benzimidazoles - pharmacology Benzimidazoles - therapeutic use Depressive Disorder - drug therapy Dipeptides - pharmacology Dipeptides - therapeutic use Exploratory Behavior - drug effects Helplessness, Learned Male Morpholines - pharmacology Morpholines - therapeutic use Psychotropic Drugs - pharmacology Psychotropic Drugs - therapeutic use Rats |
| title | Studies of long-term noopept and afobazol treatment in rats with learned helplessness neurosis |
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