EFFECT OF ISOSORBIDE DINITRATE ON GASTRIC BLOOD FLOW IN RATS WITH LIVER CIRRHOSIS DETERMINED BY ANALYZING GASTRIC BLOOD FLOW, PORTAL VEIN PRESSURE AND BLOOD GAS
We investigated the effects of isosorbide dinitrate (IDN) on gastric blood flow (GBF), portal venous pressure (PVP) and blood gas of rats with liver cirrhosis (LC) accompanied by portal hypertension. Thirty male Wistar rats (LC in 17 and normal in 13) were used. Before and after IDN administration,...
Gespeichert in:
| Veröffentlicht in: | FUKUSHIMA JOURNAL OF MEDICAL SCIENCE 2006, Vol.52(2), pp.111-124 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 124 |
|---|---|
| container_issue | 2 |
| container_start_page | 111 |
| container_title | FUKUSHIMA JOURNAL OF MEDICAL SCIENCE |
| container_volume | 52 |
| creator | TAKIGUCHI, FUJIO IRISAWA, ATSUSHI SAITO, AYAKO SAKAMOTO, HIROAKI OBARA, KATSUTOSHI KASUKAWA, REIJI OHIRA, HIROMASA |
| description | We investigated the effects of isosorbide dinitrate (IDN) on gastric blood flow (GBF), portal venous pressure (PVP) and blood gas of rats with liver cirrhosis (LC) accompanied by portal hypertension. Thirty male Wistar rats (LC in 17 and normal in 13) were used. Before and after IDN administration, GBF, PVP and blood gas in the femoral artery and portal vein were measured. Portal blood oxygen concentration was estimated by calculating the ratio of PO2 in portal blood and that in arterial blood (PpvO2/PaO2) of each rat. The GBF in the LC rats was significantly lower than that in the normal rats. In the LC group, IDN administration significantly increased the GBF. The PpvO2/PaO2 value in the group with LC was significantly lower after IDN administration than that before IDN administration. In the investigation whether changes in PVP or Ppv/PaO2 contributed more to the change in GBF after IDN administration, a significant correlation was found between rates of change in GBF and PpvO2/PaO2 were significantly correlated (r=−0.733, p |
| doi_str_mv | 10.5387/fms.52.111 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68324909</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68324909</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3831-4a0185207eee4d3789168e0086ba90e21d9c3cccdb4a73e90967ca8c28671a23</originalsourceid><addsrcrecordid>eNptkU9v0zAYh60JtJVtFz4A8onDRIrt_LFz4JAmTmspxJMTNo2L5boudGrXEbcHvg0fFaOGceFk6fXze6T3_QHwFqNpGjP6cb3z05RMMcZnYEIwS6Mkw-gVmCCEs4ikOboAb7x_RCjJKULn4ALThFCakQn4xeualz2UNRSd7KSaiYrDSrSiV0XPoWzhvOh6JUo4a6SsYN3IeyhaGH47eC_6BWzEHVewFEotZCc6WPGeq8-i5RWcPcCiLZqHr6Kd_8fzAd5K1RcNvOPBeKt4131RPESqEQqRK_B6bbbeXY_vJehr3peLqJFzURZNZGMW4ygxKCxOEHXOJauYshxnzCHEsqXJkSN4ldvYWrtaJobGLkd5Rq1hlrCMYkPiS_D-pH0e9j-Ozh_0buOt227Nk9sfvc5YTJKQCuDNCbTD3vvBrfXzsNmZ4afGSP-pQ4c6dEp0qCPA70brcblzq3_oeP8AfDoBj_5gvrkXwAyHjd26vy4yCl_m9rsZtHuKfwPCAo6i</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68324909</pqid></control><display><type>article</type><title>EFFECT OF ISOSORBIDE DINITRATE ON GASTRIC BLOOD FLOW IN RATS WITH LIVER CIRRHOSIS DETERMINED BY ANALYZING GASTRIC BLOOD FLOW, PORTAL VEIN PRESSURE AND BLOOD GAS</title><source>J-STAGE Free</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>TAKIGUCHI, FUJIO ; IRISAWA, ATSUSHI ; SAITO, AYAKO ; SAKAMOTO, HIROAKI ; OBARA, KATSUTOSHI ; KASUKAWA, REIJI ; OHIRA, HIROMASA</creator><creatorcontrib>TAKIGUCHI, FUJIO ; IRISAWA, ATSUSHI ; SAITO, AYAKO ; SAKAMOTO, HIROAKI ; OBARA, KATSUTOSHI ; KASUKAWA, REIJI ; OHIRA, HIROMASA</creatorcontrib><description>We investigated the effects of isosorbide dinitrate (IDN) on gastric blood flow (GBF), portal venous pressure (PVP) and blood gas of rats with liver cirrhosis (LC) accompanied by portal hypertension. Thirty male Wistar rats (LC in 17 and normal in 13) were used. Before and after IDN administration, GBF, PVP and blood gas in the femoral artery and portal vein were measured. Portal blood oxygen concentration was estimated by calculating the ratio of PO2 in portal blood and that in arterial blood (PpvO2/PaO2) of each rat. The GBF in the LC rats was significantly lower than that in the normal rats. In the LC group, IDN administration significantly increased the GBF. The PpvO2/PaO2 value in the group with LC was significantly lower after IDN administration than that before IDN administration. In the investigation whether changes in PVP or Ppv/PaO2 contributed more to the change in GBF after IDN administration, a significant correlation was found between rates of change in GBF and PpvO2/PaO2 were significantly correlated (r=−0.733, p<0.05). The effect of IDN on changes in the stomach accompanying portal hypertension is mainly attributable to a decrease in preload, which suppresses inflow to the stomach, as reflected by a decrease in PpvO2/PaO2, rather than to a decrease in afterload on GBF, as reflected by a decrease in PVP.</description><identifier>ISSN: 0016-2590</identifier><identifier>EISSN: 2185-4610</identifier><identifier>DOI: 10.5387/fms.52.111</identifier><identifier>PMID: 17427762</identifier><language>eng</language><publisher>Japan: THE FUKUSHIMA SOCIETY OF MEDICAL SCIENCE</publisher><subject>Animals ; Gastric Mucosa - blood supply ; Hypertension, Portal - physiopathology ; Isosorbide dinitrate ; Isosorbide Dinitrate - pharmacology ; Liver Cirrhosis, Experimental - blood ; Liver Cirrhosis, Experimental - complications ; Liver Cirrhosis, Experimental - drug therapy ; Liver Cirrhosis, Experimental - physiopathology ; Male ; Oxygen - blood ; Portal hypertension ; Portal hypertensive gastropathy ; Portal Vein - drug effects ; Portal Vein - physiopathology ; Rats ; Rats, Wistar ; Regional Blood Flow - drug effects ; Thioacetamide ; Vasodilator Agents - pharmacology ; Venous Pressure - drug effects</subject><ispartof>FUKUSHIMA JOURNAL OF MEDICAL SCIENCE, 2006, Vol.52(2), pp.111-124</ispartof><rights>2006 The Fukushima Society of Medical Science</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3831-4a0185207eee4d3789168e0086ba90e21d9c3cccdb4a73e90967ca8c28671a23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17427762$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TAKIGUCHI, FUJIO</creatorcontrib><creatorcontrib>IRISAWA, ATSUSHI</creatorcontrib><creatorcontrib>SAITO, AYAKO</creatorcontrib><creatorcontrib>SAKAMOTO, HIROAKI</creatorcontrib><creatorcontrib>OBARA, KATSUTOSHI</creatorcontrib><creatorcontrib>KASUKAWA, REIJI</creatorcontrib><creatorcontrib>OHIRA, HIROMASA</creatorcontrib><title>EFFECT OF ISOSORBIDE DINITRATE ON GASTRIC BLOOD FLOW IN RATS WITH LIVER CIRRHOSIS DETERMINED BY ANALYZING GASTRIC BLOOD FLOW, PORTAL VEIN PRESSURE AND BLOOD GAS</title><title>FUKUSHIMA JOURNAL OF MEDICAL SCIENCE</title><addtitle>Fukushima J. Med. Sci.</addtitle><description>We investigated the effects of isosorbide dinitrate (IDN) on gastric blood flow (GBF), portal venous pressure (PVP) and blood gas of rats with liver cirrhosis (LC) accompanied by portal hypertension. Thirty male Wistar rats (LC in 17 and normal in 13) were used. Before and after IDN administration, GBF, PVP and blood gas in the femoral artery and portal vein were measured. Portal blood oxygen concentration was estimated by calculating the ratio of PO2 in portal blood and that in arterial blood (PpvO2/PaO2) of each rat. The GBF in the LC rats was significantly lower than that in the normal rats. In the LC group, IDN administration significantly increased the GBF. The PpvO2/PaO2 value in the group with LC was significantly lower after IDN administration than that before IDN administration. In the investigation whether changes in PVP or Ppv/PaO2 contributed more to the change in GBF after IDN administration, a significant correlation was found between rates of change in GBF and PpvO2/PaO2 were significantly correlated (r=−0.733, p<0.05). The effect of IDN on changes in the stomach accompanying portal hypertension is mainly attributable to a decrease in preload, which suppresses inflow to the stomach, as reflected by a decrease in PpvO2/PaO2, rather than to a decrease in afterload on GBF, as reflected by a decrease in PVP.</description><subject>Animals</subject><subject>Gastric Mucosa - blood supply</subject><subject>Hypertension, Portal - physiopathology</subject><subject>Isosorbide dinitrate</subject><subject>Isosorbide Dinitrate - pharmacology</subject><subject>Liver Cirrhosis, Experimental - blood</subject><subject>Liver Cirrhosis, Experimental - complications</subject><subject>Liver Cirrhosis, Experimental - drug therapy</subject><subject>Liver Cirrhosis, Experimental - physiopathology</subject><subject>Male</subject><subject>Oxygen - blood</subject><subject>Portal hypertension</subject><subject>Portal hypertensive gastropathy</subject><subject>Portal Vein - drug effects</subject><subject>Portal Vein - physiopathology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Regional Blood Flow - drug effects</subject><subject>Thioacetamide</subject><subject>Vasodilator Agents - pharmacology</subject><subject>Venous Pressure - drug effects</subject><issn>0016-2590</issn><issn>2185-4610</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkU9v0zAYh60JtJVtFz4A8onDRIrt_LFz4JAmTmspxJMTNo2L5boudGrXEbcHvg0fFaOGceFk6fXze6T3_QHwFqNpGjP6cb3z05RMMcZnYEIwS6Mkw-gVmCCEs4ikOboAb7x_RCjJKULn4ALThFCakQn4xeualz2UNRSd7KSaiYrDSrSiV0XPoWzhvOh6JUo4a6SsYN3IeyhaGH47eC_6BWzEHVewFEotZCc6WPGeq8-i5RWcPcCiLZqHr6Kd_8fzAd5K1RcNvOPBeKt4131RPESqEQqRK_B6bbbeXY_vJehr3peLqJFzURZNZGMW4ygxKCxOEHXOJauYshxnzCHEsqXJkSN4ldvYWrtaJobGLkd5Rq1hlrCMYkPiS_D-pH0e9j-Ozh_0buOt227Nk9sfvc5YTJKQCuDNCbTD3vvBrfXzsNmZ4afGSP-pQ4c6dEp0qCPA70brcblzq3_oeP8AfDoBj_5gvrkXwAyHjd26vy4yCl_m9rsZtHuKfwPCAo6i</recordid><startdate>200612</startdate><enddate>200612</enddate><creator>TAKIGUCHI, FUJIO</creator><creator>IRISAWA, ATSUSHI</creator><creator>SAITO, AYAKO</creator><creator>SAKAMOTO, HIROAKI</creator><creator>OBARA, KATSUTOSHI</creator><creator>KASUKAWA, REIJI</creator><creator>OHIRA, HIROMASA</creator><general>THE FUKUSHIMA SOCIETY OF MEDICAL SCIENCE</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200612</creationdate><title>EFFECT OF ISOSORBIDE DINITRATE ON GASTRIC BLOOD FLOW IN RATS WITH LIVER CIRRHOSIS DETERMINED BY ANALYZING GASTRIC BLOOD FLOW, PORTAL VEIN PRESSURE AND BLOOD GAS</title><author>TAKIGUCHI, FUJIO ; IRISAWA, ATSUSHI ; SAITO, AYAKO ; SAKAMOTO, HIROAKI ; OBARA, KATSUTOSHI ; KASUKAWA, REIJI ; OHIRA, HIROMASA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3831-4a0185207eee4d3789168e0086ba90e21d9c3cccdb4a73e90967ca8c28671a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Gastric Mucosa - blood supply</topic><topic>Hypertension, Portal - physiopathology</topic><topic>Isosorbide dinitrate</topic><topic>Isosorbide Dinitrate - pharmacology</topic><topic>Liver Cirrhosis, Experimental - blood</topic><topic>Liver Cirrhosis, Experimental - complications</topic><topic>Liver Cirrhosis, Experimental - drug therapy</topic><topic>Liver Cirrhosis, Experimental - physiopathology</topic><topic>Male</topic><topic>Oxygen - blood</topic><topic>Portal hypertension</topic><topic>Portal hypertensive gastropathy</topic><topic>Portal Vein - drug effects</topic><topic>Portal Vein - physiopathology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Regional Blood Flow - drug effects</topic><topic>Thioacetamide</topic><topic>Vasodilator Agents - pharmacology</topic><topic>Venous Pressure - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TAKIGUCHI, FUJIO</creatorcontrib><creatorcontrib>IRISAWA, ATSUSHI</creatorcontrib><creatorcontrib>SAITO, AYAKO</creatorcontrib><creatorcontrib>SAKAMOTO, HIROAKI</creatorcontrib><creatorcontrib>OBARA, KATSUTOSHI</creatorcontrib><creatorcontrib>KASUKAWA, REIJI</creatorcontrib><creatorcontrib>OHIRA, HIROMASA</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>FUKUSHIMA JOURNAL OF MEDICAL SCIENCE</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TAKIGUCHI, FUJIO</au><au>IRISAWA, ATSUSHI</au><au>SAITO, AYAKO</au><au>SAKAMOTO, HIROAKI</au><au>OBARA, KATSUTOSHI</au><au>KASUKAWA, REIJI</au><au>OHIRA, HIROMASA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>EFFECT OF ISOSORBIDE DINITRATE ON GASTRIC BLOOD FLOW IN RATS WITH LIVER CIRRHOSIS DETERMINED BY ANALYZING GASTRIC BLOOD FLOW, PORTAL VEIN PRESSURE AND BLOOD GAS</atitle><jtitle>FUKUSHIMA JOURNAL OF MEDICAL SCIENCE</jtitle><addtitle>Fukushima J. Med. Sci.</addtitle><date>2006-12</date><risdate>2006</risdate><volume>52</volume><issue>2</issue><spage>111</spage><epage>124</epage><pages>111-124</pages><issn>0016-2590</issn><eissn>2185-4610</eissn><abstract>We investigated the effects of isosorbide dinitrate (IDN) on gastric blood flow (GBF), portal venous pressure (PVP) and blood gas of rats with liver cirrhosis (LC) accompanied by portal hypertension. Thirty male Wistar rats (LC in 17 and normal in 13) were used. Before and after IDN administration, GBF, PVP and blood gas in the femoral artery and portal vein were measured. Portal blood oxygen concentration was estimated by calculating the ratio of PO2 in portal blood and that in arterial blood (PpvO2/PaO2) of each rat. The GBF in the LC rats was significantly lower than that in the normal rats. In the LC group, IDN administration significantly increased the GBF. The PpvO2/PaO2 value in the group with LC was significantly lower after IDN administration than that before IDN administration. In the investigation whether changes in PVP or Ppv/PaO2 contributed more to the change in GBF after IDN administration, a significant correlation was found between rates of change in GBF and PpvO2/PaO2 were significantly correlated (r=−0.733, p<0.05). The effect of IDN on changes in the stomach accompanying portal hypertension is mainly attributable to a decrease in preload, which suppresses inflow to the stomach, as reflected by a decrease in PpvO2/PaO2, rather than to a decrease in afterload on GBF, as reflected by a decrease in PVP.</abstract><cop>Japan</cop><pub>THE FUKUSHIMA SOCIETY OF MEDICAL SCIENCE</pub><pmid>17427762</pmid><doi>10.5387/fms.52.111</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0016-2590 |
| ispartof | FUKUSHIMA JOURNAL OF MEDICAL SCIENCE, 2006, Vol.52(2), pp.111-124 |
| issn | 0016-2590 2185-4610 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68324909 |
| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Gastric Mucosa - blood supply Hypertension, Portal - physiopathology Isosorbide dinitrate Isosorbide Dinitrate - pharmacology Liver Cirrhosis, Experimental - blood Liver Cirrhosis, Experimental - complications Liver Cirrhosis, Experimental - drug therapy Liver Cirrhosis, Experimental - physiopathology Male Oxygen - blood Portal hypertension Portal hypertensive gastropathy Portal Vein - drug effects Portal Vein - physiopathology Rats Rats, Wistar Regional Blood Flow - drug effects Thioacetamide Vasodilator Agents - pharmacology Venous Pressure - drug effects |
| title | EFFECT OF ISOSORBIDE DINITRATE ON GASTRIC BLOOD FLOW IN RATS WITH LIVER CIRRHOSIS DETERMINED BY ANALYZING GASTRIC BLOOD FLOW, PORTAL VEIN PRESSURE AND BLOOD GAS |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T14%3A02%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=EFFECT%20OF%20ISOSORBIDE%20DINITRATE%20ON%20GASTRIC%20BLOOD%20FLOW%20IN%20RATS%20WITH%20LIVER%20CIRRHOSIS%20DETERMINED%20BY%20ANALYZING%20GASTRIC%20BLOOD%20FLOW,%20PORTAL%20VEIN%20PRESSURE%20AND%20BLOOD%20GAS&rft.jtitle=FUKUSHIMA%20JOURNAL%20OF%20MEDICAL%20SCIENCE&rft.au=TAKIGUCHI,%20FUJIO&rft.date=2006-12&rft.volume=52&rft.issue=2&rft.spage=111&rft.epage=124&rft.pages=111-124&rft.issn=0016-2590&rft.eissn=2185-4610&rft_id=info:doi/10.5387/fms.52.111&rft_dat=%3Cproquest_cross%3E68324909%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68324909&rft_id=info:pmid/17427762&rfr_iscdi=true |