Immunohistochemical Expression of Mina53 and Ki67 Proteins in Human Primary Gingival Squamous Cell Carcinoma
Studies have reported the presence of relationships between the Myc target gene Mina53 and poor prognostic factors in several cancers including esophageal cancer. In this study, we investigated the relationships between Mina53 expression in gingival squamous cell carcinoma and clinicopathological fa...
Gespeichert in:
| Veröffentlicht in: | Kurume medical journal 2006/12/31, Vol.53(3+4), pp.71-78 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 78 |
|---|---|
| container_issue | 3+4 |
| container_start_page | 71 |
| container_title | Kurume medical journal |
| container_volume | 53 |
| creator | KURATOMI, KEITARO YANO, HIROHISA TSUNEOKA, MAKOTO SAKAMOTO, KIKUO KUSUKAWA, JINGO KOJIRO, MASAMICHI |
| description | Studies have reported the presence of relationships between the Myc target gene Mina53 and poor prognostic factors in several cancers including esophageal cancer. In this study, we investigated the relationships between Mina53 expression in gingival squamous cell carcinoma and clinicopathological factors. Seven samples of normal and dysplastic gingival tissues and 15 samples of gingival squamous cell carcinoma were immunostained for Mina53 and Ki67, and examined for the relationships between their expression and differentiation degree, lymph node metastasis, stage, tumor diameter, and prognosis. In normal and dysplastic gingival tissues, the localization of the expression of Mina53 and Ki67 was similar, but that in gingival squamous cell carcinoma tissue varied depending on the degree of differentiation. In well-differentiated GSCC with pearl formation, Mina53 was negative at the center of the clearly keratinized cancer nest, but positive in the nuclei of cells in the periphery and adjacent area of the cancer nest. In diffusely proliferating undifferentiated and moderately-differentiated GSCC showing no pearl formation, both Mina53 tended to be positive in the nuclei of cancer cells in the entire cancer nest. A significant correlation was found between the expression of Mina53 and that of Ki67 in patients with gingival squamous cell carcinoma or dysplastic gingiva. No significant correlation was noted between the expression of Mina53 or Ki67 and prognostic factors such as the degree of differentiation, lymph node metastasis, stage, and tumor diameter. In gingival squamous cell carcinoma, Mina53 expression was correlated with the proliferation of tumor cells, but unlike esophageal and other squamous cell carcinomas, not with the prognosis. The absence of correlations with prognostic factors suggests that may differ gingival squamous cell carcinoma differs biologically from esophageal squamous cell carcinoma which is correlated with Mina53 in terms of the biological expression of Mina53. |
| doi_str_mv | 10.2739/kurumemedj.53.71 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68322409</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68322409</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5111-b91958420940faf65710c4c017589edd6d8aaa75daee95577cd175fbc0232a023</originalsourceid><addsrcrecordid>eNpdkEFPGzEQhS1UBClw76nyqbcN9nq9Xh-rKIWoQSABZ2vi9SZO13Zi71bw73GVFCQuM9LMN0_zHkLfKJmWgsnrP2McnXGm3U45mwp6gia0aWhREkm-oAkhJSt4LeQ5-prSlpCqaUpyhs6pYFRIxieoXzg3-rCxaQh6Y5zV0OP5yy6alGzwOHT4znrgDINv8W9bC_wQw2CsT9h6fDs68HliHcRXfGP92v7NAo_7EVwYE56ZvscziNr64OASnXbQJ3N17Bfo-df8aXZbLO9vFrOfy0JzSmmxklTypsomKtJBV3NBia40oYI30rRt3TYAIHgLxkjOhdBtXnUrne2WkMsF-nHQ3cWwH00alLNJ51fAm_yVqhtWlhWRGSQHUMeQUjSd2h2sKErUv4TVR8KKMyVoPvl-1B5XefxxcIw0A4sDsE0DrM07AHGwujefFJmq_jdB3xm9gaiMZ2_iUJU_</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68322409</pqid></control><display><type>article</type><title>Immunohistochemical Expression of Mina53 and Ki67 Proteins in Human Primary Gingival Squamous Cell Carcinoma</title><source>J-STAGE Free</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>KURATOMI, KEITARO ; YANO, HIROHISA ; TSUNEOKA, MAKOTO ; SAKAMOTO, KIKUO ; KUSUKAWA, JINGO ; KOJIRO, MASAMICHI</creator><creatorcontrib>KURATOMI, KEITARO ; YANO, HIROHISA ; TSUNEOKA, MAKOTO ; SAKAMOTO, KIKUO ; KUSUKAWA, JINGO ; KOJIRO, MASAMICHI</creatorcontrib><description>Studies have reported the presence of relationships between the Myc target gene Mina53 and poor prognostic factors in several cancers including esophageal cancer. In this study, we investigated the relationships between Mina53 expression in gingival squamous cell carcinoma and clinicopathological factors. Seven samples of normal and dysplastic gingival tissues and 15 samples of gingival squamous cell carcinoma were immunostained for Mina53 and Ki67, and examined for the relationships between their expression and differentiation degree, lymph node metastasis, stage, tumor diameter, and prognosis. In normal and dysplastic gingival tissues, the localization of the expression of Mina53 and Ki67 was similar, but that in gingival squamous cell carcinoma tissue varied depending on the degree of differentiation. In well-differentiated GSCC with pearl formation, Mina53 was negative at the center of the clearly keratinized cancer nest, but positive in the nuclei of cells in the periphery and adjacent area of the cancer nest. In diffusely proliferating undifferentiated and moderately-differentiated GSCC showing no pearl formation, both Mina53 tended to be positive in the nuclei of cancer cells in the entire cancer nest. A significant correlation was found between the expression of Mina53 and that of Ki67 in patients with gingival squamous cell carcinoma or dysplastic gingiva. No significant correlation was noted between the expression of Mina53 or Ki67 and prognostic factors such as the degree of differentiation, lymph node metastasis, stage, and tumor diameter. In gingival squamous cell carcinoma, Mina53 expression was correlated with the proliferation of tumor cells, but unlike esophageal and other squamous cell carcinomas, not with the prognosis. The absence of correlations with prognostic factors suggests that may differ gingival squamous cell carcinoma differs biologically from esophageal squamous cell carcinoma which is correlated with Mina53 in terms of the biological expression of Mina53.</description><identifier>ISSN: 0023-5679</identifier><identifier>EISSN: 1881-2090</identifier><identifier>DOI: 10.2739/kurumemedj.53.71</identifier><identifier>PMID: 17317935</identifier><language>eng</language><publisher>Japan: Kurume University School of Medicine</publisher><subject>Aged ; Aged, 80 and over ; Carcinoma, Squamous Cell - chemistry ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - pathology ; Female ; Gingival Neoplasms - chemistry ; Gingival Neoplasms - mortality ; Gingival Neoplasms - pathology ; gingival squamous cell carcinoma ; Humans ; Immunohistochemistry ; Ki-67 Antigen - analysis ; Ki67 ; Male ; Middle Aged ; Mina53 ; Nuclear Proteins - analysis ; Survival Rate</subject><ispartof>The Kurume Medical Journal, 2006/12/31, Vol.53(3+4), pp.71-78</ispartof><rights>2006 Kurume University School of Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5111-b91958420940faf65710c4c017589edd6d8aaa75daee95577cd175fbc0232a023</citedby><cites>FETCH-LOGICAL-c5111-b91958420940faf65710c4c017589edd6d8aaa75daee95577cd175fbc0232a023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17317935$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KURATOMI, KEITARO</creatorcontrib><creatorcontrib>YANO, HIROHISA</creatorcontrib><creatorcontrib>TSUNEOKA, MAKOTO</creatorcontrib><creatorcontrib>SAKAMOTO, KIKUO</creatorcontrib><creatorcontrib>KUSUKAWA, JINGO</creatorcontrib><creatorcontrib>KOJIRO, MASAMICHI</creatorcontrib><title>Immunohistochemical Expression of Mina53 and Ki67 Proteins in Human Primary Gingival Squamous Cell Carcinoma</title><title>Kurume medical journal</title><addtitle>Kurume Med. J.</addtitle><description>Studies have reported the presence of relationships between the Myc target gene Mina53 and poor prognostic factors in several cancers including esophageal cancer. In this study, we investigated the relationships between Mina53 expression in gingival squamous cell carcinoma and clinicopathological factors. Seven samples of normal and dysplastic gingival tissues and 15 samples of gingival squamous cell carcinoma were immunostained for Mina53 and Ki67, and examined for the relationships between their expression and differentiation degree, lymph node metastasis, stage, tumor diameter, and prognosis. In normal and dysplastic gingival tissues, the localization of the expression of Mina53 and Ki67 was similar, but that in gingival squamous cell carcinoma tissue varied depending on the degree of differentiation. In well-differentiated GSCC with pearl formation, Mina53 was negative at the center of the clearly keratinized cancer nest, but positive in the nuclei of cells in the periphery and adjacent area of the cancer nest. In diffusely proliferating undifferentiated and moderately-differentiated GSCC showing no pearl formation, both Mina53 tended to be positive in the nuclei of cancer cells in the entire cancer nest. A significant correlation was found between the expression of Mina53 and that of Ki67 in patients with gingival squamous cell carcinoma or dysplastic gingiva. No significant correlation was noted between the expression of Mina53 or Ki67 and prognostic factors such as the degree of differentiation, lymph node metastasis, stage, and tumor diameter. In gingival squamous cell carcinoma, Mina53 expression was correlated with the proliferation of tumor cells, but unlike esophageal and other squamous cell carcinomas, not with the prognosis. The absence of correlations with prognostic factors suggests that may differ gingival squamous cell carcinoma differs biologically from esophageal squamous cell carcinoma which is correlated with Mina53 in terms of the biological expression of Mina53.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carcinoma, Squamous Cell - chemistry</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Female</subject><subject>Gingival Neoplasms - chemistry</subject><subject>Gingival Neoplasms - mortality</subject><subject>Gingival Neoplasms - pathology</subject><subject>gingival squamous cell carcinoma</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Ki-67 Antigen - analysis</subject><subject>Ki67</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mina53</subject><subject>Nuclear Proteins - analysis</subject><subject>Survival Rate</subject><issn>0023-5679</issn><issn>1881-2090</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkEFPGzEQhS1UBClw76nyqbcN9nq9Xh-rKIWoQSABZ2vi9SZO13Zi71bw73GVFCQuM9LMN0_zHkLfKJmWgsnrP2McnXGm3U45mwp6gia0aWhREkm-oAkhJSt4LeQ5-prSlpCqaUpyhs6pYFRIxieoXzg3-rCxaQh6Y5zV0OP5yy6alGzwOHT4znrgDINv8W9bC_wQw2CsT9h6fDs68HliHcRXfGP92v7NAo_7EVwYE56ZvscziNr64OASnXbQJ3N17Bfo-df8aXZbLO9vFrOfy0JzSmmxklTypsomKtJBV3NBia40oYI30rRt3TYAIHgLxkjOhdBtXnUrne2WkMsF-nHQ3cWwH00alLNJ51fAm_yVqhtWlhWRGSQHUMeQUjSd2h2sKErUv4TVR8KKMyVoPvl-1B5XefxxcIw0A4sDsE0DrM07AHGwujefFJmq_jdB3xm9gaiMZ2_iUJU_</recordid><startdate>2006</startdate><enddate>2006</enddate><creator>KURATOMI, KEITARO</creator><creator>YANO, HIROHISA</creator><creator>TSUNEOKA, MAKOTO</creator><creator>SAKAMOTO, KIKUO</creator><creator>KUSUKAWA, JINGO</creator><creator>KOJIRO, MASAMICHI</creator><general>Kurume University School of Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2006</creationdate><title>Immunohistochemical Expression of Mina53 and Ki67 Proteins in Human Primary Gingival Squamous Cell Carcinoma</title><author>KURATOMI, KEITARO ; YANO, HIROHISA ; TSUNEOKA, MAKOTO ; SAKAMOTO, KIKUO ; KUSUKAWA, JINGO ; KOJIRO, MASAMICHI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5111-b91958420940faf65710c4c017589edd6d8aaa75daee95577cd175fbc0232a023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Carcinoma, Squamous Cell - chemistry</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Female</topic><topic>Gingival Neoplasms - chemistry</topic><topic>Gingival Neoplasms - mortality</topic><topic>Gingival Neoplasms - pathology</topic><topic>gingival squamous cell carcinoma</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Ki-67 Antigen - analysis</topic><topic>Ki67</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mina53</topic><topic>Nuclear Proteins - analysis</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KURATOMI, KEITARO</creatorcontrib><creatorcontrib>YANO, HIROHISA</creatorcontrib><creatorcontrib>TSUNEOKA, MAKOTO</creatorcontrib><creatorcontrib>SAKAMOTO, KIKUO</creatorcontrib><creatorcontrib>KUSUKAWA, JINGO</creatorcontrib><creatorcontrib>KOJIRO, MASAMICHI</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Kurume medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KURATOMI, KEITARO</au><au>YANO, HIROHISA</au><au>TSUNEOKA, MAKOTO</au><au>SAKAMOTO, KIKUO</au><au>KUSUKAWA, JINGO</au><au>KOJIRO, MASAMICHI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunohistochemical Expression of Mina53 and Ki67 Proteins in Human Primary Gingival Squamous Cell Carcinoma</atitle><jtitle>Kurume medical journal</jtitle><addtitle>Kurume Med. J.</addtitle><date>2006</date><risdate>2006</risdate><volume>53</volume><issue>3+4</issue><spage>71</spage><epage>78</epage><pages>71-78</pages><issn>0023-5679</issn><eissn>1881-2090</eissn><abstract>Studies have reported the presence of relationships between the Myc target gene Mina53 and poor prognostic factors in several cancers including esophageal cancer. In this study, we investigated the relationships between Mina53 expression in gingival squamous cell carcinoma and clinicopathological factors. Seven samples of normal and dysplastic gingival tissues and 15 samples of gingival squamous cell carcinoma were immunostained for Mina53 and Ki67, and examined for the relationships between their expression and differentiation degree, lymph node metastasis, stage, tumor diameter, and prognosis. In normal and dysplastic gingival tissues, the localization of the expression of Mina53 and Ki67 was similar, but that in gingival squamous cell carcinoma tissue varied depending on the degree of differentiation. In well-differentiated GSCC with pearl formation, Mina53 was negative at the center of the clearly keratinized cancer nest, but positive in the nuclei of cells in the periphery and adjacent area of the cancer nest. In diffusely proliferating undifferentiated and moderately-differentiated GSCC showing no pearl formation, both Mina53 tended to be positive in the nuclei of cancer cells in the entire cancer nest. A significant correlation was found between the expression of Mina53 and that of Ki67 in patients with gingival squamous cell carcinoma or dysplastic gingiva. No significant correlation was noted between the expression of Mina53 or Ki67 and prognostic factors such as the degree of differentiation, lymph node metastasis, stage, and tumor diameter. In gingival squamous cell carcinoma, Mina53 expression was correlated with the proliferation of tumor cells, but unlike esophageal and other squamous cell carcinomas, not with the prognosis. The absence of correlations with prognostic factors suggests that may differ gingival squamous cell carcinoma differs biologically from esophageal squamous cell carcinoma which is correlated with Mina53 in terms of the biological expression of Mina53.</abstract><cop>Japan</cop><pub>Kurume University School of Medicine</pub><pmid>17317935</pmid><doi>10.2739/kurumemedj.53.71</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0023-5679 |
| ispartof | The Kurume Medical Journal, 2006/12/31, Vol.53(3+4), pp.71-78 |
| issn | 0023-5679 1881-2090 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68322409 |
| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Aged Aged, 80 and over Carcinoma, Squamous Cell - chemistry Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Female Gingival Neoplasms - chemistry Gingival Neoplasms - mortality Gingival Neoplasms - pathology gingival squamous cell carcinoma Humans Immunohistochemistry Ki-67 Antigen - analysis Ki67 Male Middle Aged Mina53 Nuclear Proteins - analysis Survival Rate |
| title | Immunohistochemical Expression of Mina53 and Ki67 Proteins in Human Primary Gingival Squamous Cell Carcinoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T13%3A53%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Immunohistochemical%20Expression%20of%20Mina53%20and%20Ki67%20Proteins%20in%20Human%20Primary%20Gingival%20Squamous%20Cell%20Carcinoma&rft.jtitle=Kurume%20medical%20journal&rft.au=KURATOMI,%20KEITARO&rft.date=2006&rft.volume=53&rft.issue=3+4&rft.spage=71&rft.epage=78&rft.pages=71-78&rft.issn=0023-5679&rft.eissn=1881-2090&rft_id=info:doi/10.2739/kurumemedj.53.71&rft_dat=%3Cproquest_cross%3E68322409%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68322409&rft_id=info:pmid/17317935&rfr_iscdi=true |