Enhanced production and dendritic growth of new dentate granule cells in the middle-aged hippocampus following intracerebroventricular FGF-2 infusions

Declined production and diminished dendritic growth of new dentate granule cells in the middle‐aged and aged hippocampus are correlated with diminished concentration of fibroblast growth factor‐2 (FGF‐2). This study examined whether increased FGF‐2 concentration in the milieu boosts both production...

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Veröffentlicht in:	The European journal of neuroscience 2007-10, Vol.26 (7), p.1765-1779
Hauptverfasser:	Rai, Kiranmai S., Hattiangady, Bharathi, Shetty, Ashok K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bromodeoxyuridine - metabolism Cell Count Cell Growth Processes - drug effects Dendrites - drug effects dentate neurogenesis Fibroblast Growth Factor 2 - pharmacology Functional Laterality Glial Fibrillary Acidic Protein - metabolism hippocampal aging hippocampal stem cells Hippocampus - cytology Hippocampus - drug effects Injections, Intraventricular - methods learning and memory Male Microtubule-Associated Proteins - metabolism neural stem cells Neurons - cytology Neurons - drug effects Neuropeptides - metabolism Rats Rats, Inbred F344 Tubulin - metabolism
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