Neutralizing IL‐7 Promotes Long‐Term Allograft Survival Induced by CD40/CD40L Costimulatory Blockade

Memory T cells are somewhat resistant to immunosuppresion. They therefore pose a threat to inducing long‐term allograft survival. IL‐7 is essential for memory T‐cell generation. Here, we investigated whether neutralizing IL‐7 promotes allograft survival. We found that neutralizing IL‐7 alone did not...

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Veröffentlicht in:	American journal of transplantation 2006-12, Vol.6 (12), p.2851-2860
Hauptverfasser:	Wang, Y., Dai, H., Liu, Z., Cheng, X., Tellides, G., Dai, Z.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allograft survival Animals Biological and medical sciences CD40 Antigens - antagonists & inhibitors CD40 Ligand - antagonists & inhibitors Cell Division Dendritic Cells - cytology Dendritic Cells - immunology Graft Survival - immunology growth factor Heart Transplantation - immunology Immunologic Memory Immunophenotyping Interleukin-7 - immunology Lymphocyte Activation Medical sciences memory T cells Mice Mice, Inbred C57BL Neutralization Tests Peptidyl-Dipeptidase A - metabolism Skin Transplantation - immunology Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases T-Lymphocytes - immunology Transplantation, Homologous - immunology
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