Peroxiredoxin V in multiple sclerosis lesions: predominant expression by astrocytes

Oxidative stress is implicated in the pathogenesis of multiple sclerosis (MS). Defence against oxidative damage is mediated by antioxidants. Peroxiredoxin V (PRDX V) is an intracellular anti-oxidant enzyme with peroxynitrite reductase activity. It is increased during inflammation, when free radical...

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Veröffentlicht in:	Multiple sclerosis 2007-09, Vol.13 (8), p.955-961
Hauptverfasser:	Holley, J.E., Newcombe, J., Winyard, P.G., Gutowski, N.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Astrocytes - pathology Biological and medical sciences Brain - cytology Brain - pathology Cadaver Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Gene Expression Regulation Humans Immunoblotting Immunohistochemistry Immunomodulators Medical sciences Multiple Sclerosis - pathology Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology Peroxiredoxins - metabolism Pharmacology. Drug treatments Reference Values
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