Conjunctival Epithelial Changes Induced by Cilia in Patients with Epiblepharon or Entropion
Purpose To evaluate the effect of mechanical trauma induced by cilia on the conjunctival epithelium in patients with epiblepharon or entropion and to evaluate changes in epithelium after surgical correction in patients with entropion. Design Case-control study. Methods One hundred and seven eyes of...
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| Veröffentlicht in: | American journal of ophthalmology 2007-10, Vol.144 (4), p.564-569 |
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| creator | Kim, Cinoo Shin, Young Joo Kim, Nam Ju Khwarg, Sang In Hwang, Jeong-Min Wee, Won Ryang |
| description | Purpose To evaluate the effect of mechanical trauma induced by cilia on the conjunctival epithelium in patients with epiblepharon or entropion and to evaluate changes in epithelium after surgical correction in patients with entropion. Design Case-control study. Methods One hundred and seven eyes of 61 patients were enrolled in this study and were divided into three groups: the epiblepharon group (n = 59), the entropion group (n = 17), and the age-matched control group for the epiblepharon group (n = 31). Impression cytologic specimens were obtained from nasal and temporal bulbar conjunctiva of the epiblepharon and control groups immediately after the induction of general anesthesia. In the entropion group, these were obtained before and one month after surgical correction. Conjunctival changes were graded using the Tseng method and goblet cell densities were compared. Results Cytologic scores were significantly higher in the epiblepharon group than in the control group ( P < .001), and goblet cell densities of nasal and temporal conjunctiva were significantly lower in the epiblepharon group than in the control group ( P = .044 and P = .018, respectively). In the entropion group, postoperative scores were significantly lower than preoperative scores in both conjunctival areas ( P = .033 and P = .003, respectively). No statistically significant difference was found between nasal and temporal conjunctiva in the three groups. Conclusions The persistent mechanical trauma by cilia in patients with epiblepharon or entropion can induce squamous metaplasia of the conjunctival epithelium. However, these conjunctival changes can be reversed by surgical correction. |
| doi_str_mv | 10.1016/j.ajo.2007.06.022 |
| format | Article |
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Design Case-control study. Methods One hundred and seven eyes of 61 patients were enrolled in this study and were divided into three groups: the epiblepharon group (n = 59), the entropion group (n = 17), and the age-matched control group for the epiblepharon group (n = 31). Impression cytologic specimens were obtained from nasal and temporal bulbar conjunctiva of the epiblepharon and control groups immediately after the induction of general anesthesia. In the entropion group, these were obtained before and one month after surgical correction. Conjunctival changes were graded using the Tseng method and goblet cell densities were compared. Results Cytologic scores were significantly higher in the epiblepharon group than in the control group ( P < .001), and goblet cell densities of nasal and temporal conjunctiva were significantly lower in the epiblepharon group than in the control group ( P = .044 and P = .018, respectively). In the entropion group, postoperative scores were significantly lower than preoperative scores in both conjunctival areas ( P = .033 and P = .003, respectively). No statistically significant difference was found between nasal and temporal conjunctiva in the three groups. Conclusions The persistent mechanical trauma by cilia in patients with epiblepharon or entropion can induce squamous metaplasia of the conjunctival epithelium. However, these conjunctival changes can be reversed by surgical correction.</description><identifier>ISSN: 0002-9394</identifier><identifier>EISSN: 1879-1891</identifier><identifier>DOI: 10.1016/j.ajo.2007.06.022</identifier><identifier>PMID: 17692275</identifier><identifier>CODEN: AJOPAA</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Age ; Aged ; Biological and medical sciences ; Case-Control Studies ; Cell Count ; Child ; Child, Preschool ; Conjunctiva - pathology ; Conjunctival Diseases - etiology ; Contact lenses ; Cytoplasm ; Entropion - complications ; Epithelial Cells - pathology ; Eyelashes ; Eyelid Diseases - complications ; Female ; Goblet Cells - pathology ; Hair Diseases - complications ; Hospitals ; Humans ; Infant ; Male ; Medical sciences ; Membrane filters ; Metaplasia ; Middle Aged ; Miscellaneous ; Ophthalmology ; Patients ; Statistical analysis ; Surgery</subject><ispartof>American journal of ophthalmology, 2007-10, Vol.144 (4), p.564-569</ispartof><rights>Elsevier Inc.</rights><rights>2007 Elsevier Inc.</rights><rights>2008 INIST-CNRS</rights><rights>Copyright Elsevier Limited Oct 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-7aedd001f4bae84b501f8b7b2aa9d2f1c7282353a90e28c764428ef53e264ab93</citedby><cites>FETCH-LOGICAL-c464t-7aedd001f4bae84b501f8b7b2aa9d2f1c7282353a90e28c764428ef53e264ab93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ajo.2007.06.022$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3541,27915,27916,45986</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20059877$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17692275$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Cinoo</creatorcontrib><creatorcontrib>Shin, Young Joo</creatorcontrib><creatorcontrib>Kim, Nam Ju</creatorcontrib><creatorcontrib>Khwarg, Sang In</creatorcontrib><creatorcontrib>Hwang, Jeong-Min</creatorcontrib><creatorcontrib>Wee, Won Ryang</creatorcontrib><title>Conjunctival Epithelial Changes Induced by Cilia in Patients with Epiblepharon or Entropion</title><title>American journal of ophthalmology</title><addtitle>Am J Ophthalmol</addtitle><description>Purpose To evaluate the effect of mechanical trauma induced by cilia on the conjunctival epithelium in patients with epiblepharon or entropion and to evaluate changes in epithelium after surgical correction in patients with entropion. Design Case-control study. Methods One hundred and seven eyes of 61 patients were enrolled in this study and were divided into three groups: the epiblepharon group (n = 59), the entropion group (n = 17), and the age-matched control group for the epiblepharon group (n = 31). Impression cytologic specimens were obtained from nasal and temporal bulbar conjunctiva of the epiblepharon and control groups immediately after the induction of general anesthesia. In the entropion group, these were obtained before and one month after surgical correction. Conjunctival changes were graded using the Tseng method and goblet cell densities were compared. Results Cytologic scores were significantly higher in the epiblepharon group than in the control group ( P < .001), and goblet cell densities of nasal and temporal conjunctiva were significantly lower in the epiblepharon group than in the control group ( P = .044 and P = .018, respectively). In the entropion group, postoperative scores were significantly lower than preoperative scores in both conjunctival areas ( P = .033 and P = .003, respectively). No statistically significant difference was found between nasal and temporal conjunctiva in the three groups. Conclusions The persistent mechanical trauma by cilia in patients with epiblepharon or entropion can induce squamous metaplasia of the conjunctival epithelium. However, these conjunctival changes can be reversed by surgical correction.</description><subject>Adolescent</subject><subject>Age</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Cell Count</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Conjunctiva - pathology</subject><subject>Conjunctival Diseases - etiology</subject><subject>Contact lenses</subject><subject>Cytoplasm</subject><subject>Entropion - complications</subject><subject>Epithelial Cells - pathology</subject><subject>Eyelashes</subject><subject>Eyelid Diseases - complications</subject><subject>Female</subject><subject>Goblet Cells - pathology</subject><subject>Hair Diseases - complications</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Membrane filters</subject><subject>Metaplasia</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Ophthalmology</subject><subject>Patients</subject><subject>Statistical analysis</subject><subject>Surgery</subject><issn>0002-9394</issn><issn>1879-1891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kl-L1DAUxYMo7rj6AXyRguhba5Km-YMgSBl1YUFBffIhpOmtk9pJZpN2Zb69qTO4sA8-5Yb8zrk3J0HoOcEVwYS_GSszhopiLCrMK0zpA7QhUqiSSEUeog3GmJaqVuwCPUlpzFsumHiMLojgilLRbNCPNvhx8XZ2t2Yqtgc372ByuWx3xv-EVFz5frHQF92xaF0-KZwvvpjZgZ9T8Tvjq6ib4LAzMfgixGLr5xgOLvin6NFgpgTPzusl-v5h-639VF5__njVvr8uLeNsLoWBvseYDKwzIFnX5FJ2oqPGqJ4OxAoqad3URmGg0grOGJUwNDVQzkyn6kv0-uR7iOFmgTTrvUsWpsl4CEvSXNaESSIy-PIeOIYl-jybJtlVCYEFzxQ5UTaGlCIM-hDd3sSjJlivuetR59z1mrvGXOfcs-bF2Xnp9tDfKc5BZ-DVGTDJmmmIxluX_nHZq1FSrCO-PXGQA7t1EHWyOev8Ai6CnXUf3H_HeHdPbSfnXW74C46Q7m6rE9VYf10_yPo_sPjbv67_AKp7tD4</recordid><startdate>20071001</startdate><enddate>20071001</enddate><creator>Kim, Cinoo</creator><creator>Shin, Young Joo</creator><creator>Kim, Nam Ju</creator><creator>Khwarg, Sang In</creator><creator>Hwang, Jeong-Min</creator><creator>Wee, Won Ryang</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20071001</creationdate><title>Conjunctival Epithelial Changes Induced by Cilia in Patients with Epiblepharon or Entropion</title><author>Kim, Cinoo ; Shin, Young Joo ; Kim, Nam Ju ; Khwarg, Sang In ; Hwang, Jeong-Min ; Wee, Won Ryang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-7aedd001f4bae84b501f8b7b2aa9d2f1c7282353a90e28c764428ef53e264ab93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>Age</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Cell Count</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Conjunctiva - pathology</topic><topic>Conjunctival Diseases - etiology</topic><topic>Contact lenses</topic><topic>Cytoplasm</topic><topic>Entropion - complications</topic><topic>Epithelial Cells - pathology</topic><topic>Eyelashes</topic><topic>Eyelid Diseases - complications</topic><topic>Female</topic><topic>Goblet Cells - pathology</topic><topic>Hair Diseases - complications</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Membrane filters</topic><topic>Metaplasia</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Ophthalmology</topic><topic>Patients</topic><topic>Statistical analysis</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Cinoo</creatorcontrib><creatorcontrib>Shin, Young Joo</creatorcontrib><creatorcontrib>Kim, Nam Ju</creatorcontrib><creatorcontrib>Khwarg, Sang In</creatorcontrib><creatorcontrib>Hwang, Jeong-Min</creatorcontrib><creatorcontrib>Wee, Won Ryang</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Cinoo</au><au>Shin, Young Joo</au><au>Kim, Nam Ju</au><au>Khwarg, Sang In</au><au>Hwang, Jeong-Min</au><au>Wee, Won Ryang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Conjunctival Epithelial Changes Induced by Cilia in Patients with Epiblepharon or Entropion</atitle><jtitle>American journal of ophthalmology</jtitle><addtitle>Am J Ophthalmol</addtitle><date>2007-10-01</date><risdate>2007</risdate><volume>144</volume><issue>4</issue><spage>564</spage><epage>569</epage><pages>564-569</pages><issn>0002-9394</issn><eissn>1879-1891</eissn><coden>AJOPAA</coden><abstract>Purpose To evaluate the effect of mechanical trauma induced by cilia on the conjunctival epithelium in patients with epiblepharon or entropion and to evaluate changes in epithelium after surgical correction in patients with entropion. Design Case-control study. Methods One hundred and seven eyes of 61 patients were enrolled in this study and were divided into three groups: the epiblepharon group (n = 59), the entropion group (n = 17), and the age-matched control group for the epiblepharon group (n = 31). Impression cytologic specimens were obtained from nasal and temporal bulbar conjunctiva of the epiblepharon and control groups immediately after the induction of general anesthesia. In the entropion group, these were obtained before and one month after surgical correction. Conjunctival changes were graded using the Tseng method and goblet cell densities were compared. Results Cytologic scores were significantly higher in the epiblepharon group than in the control group ( P < .001), and goblet cell densities of nasal and temporal conjunctiva were significantly lower in the epiblepharon group than in the control group ( P = .044 and P = .018, respectively). In the entropion group, postoperative scores were significantly lower than preoperative scores in both conjunctival areas ( P = .033 and P = .003, respectively). No statistically significant difference was found between nasal and temporal conjunctiva in the three groups. Conclusions The persistent mechanical trauma by cilia in patients with epiblepharon or entropion can induce squamous metaplasia of the conjunctival epithelium. However, these conjunctival changes can be reversed by surgical correction.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>17692275</pmid><doi>10.1016/j.ajo.2007.06.022</doi><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Age Aged Biological and medical sciences Case-Control Studies Cell Count Child Child, Preschool Conjunctiva - pathology Conjunctival Diseases - etiology Contact lenses Cytoplasm Entropion - complications Epithelial Cells - pathology Eyelashes Eyelid Diseases - complications Female Goblet Cells - pathology Hair Diseases - complications Hospitals Humans Infant Male Medical sciences Membrane filters Metaplasia Middle Aged Miscellaneous Ophthalmology Patients Statistical analysis Surgery |
| title | Conjunctival Epithelial Changes Induced by Cilia in Patients with Epiblepharon or Entropion |
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