Overexpression of apolipoprotein CIII increases and CETP reverses diet-induced obesity in transgenic mice

Objective: We recently described that hypertriglyceridemic apolipoprotein (apo) CIII transgenic mice show increased whole body metabolic rate. In this study, we used these apo CIII-expressing mice, combined or not with the expression of the natural promoter-driven CETP gene, to test the hypothesis t...

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Veröffentlicht in:	International Journal of Obesity 2007-10, Vol.31 (10), p.1586-1595
Hauptverfasser:	Salerno, A.G, Silva, T.R, Amaral, M.E.C, Alberici, L.C, Bonfleur, M.L, Patricio, P.R, Francesconi, E.P.M.S, Grassi-Kassisse, D.M, Vercesi, A.E, Boschero, A.C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Adipose tissue animal models Animals Apolipoprotein C-III - physiology Apolipoproteins Atherosclerosis Biological and medical sciences blood chemistry blood glucose blood proteins Body Composition - physiology Body fat Body temperature Body weight Body Weight - physiology cell respiration Cholesterol Cholesterol Ester Transfer Proteins - physiology cholesteryl ester transfer protein Diet Disorders of blood lipids. Hyperlipoproteinemia Epidemiology Fasting - blood Fasting - metabolism Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Gene expression genes Genetic aspects Genotypes Health aspects Health Promotion and Disease Prevention High density lipoprotein high fat diet Hypertriglyceridemia - blood Hypertriglyceridemia - metabolism Hypotheses Insulin Internal Medicine leptin Leptin - metabolism Lipoproteins Liver Medical sciences Medicine Medicine & Public Health Metabolic Diseases Metabolism Mice Mice, Inbred C57BL Mice, Transgenic molecular sequence data Obesity original-article phenotype Physiology Plasma postprandial state promoter regions protein synthesis Proteins Public Health Respiration Risk factors Transgenic animals Vertebrates: anatomy and physiology, studies on body, several organs or systems visceral fat Weaning
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