Subacute Combined Degeneration Due to Copper Deficiency
ABSTRACT There is growing clinical evidence supporting a connection between copper deficiency and subacute combined degeneration. While nearly half of patients with copper deficiency myelopathy exhibit MRI abnormalities, signal changes are often ill‐defined in distribution. We report a patient with...
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| Veröffentlicht in: | Journal of neuroimaging 2007-10, Vol.17 (4), p.375-377 |
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| container_end_page | 377 |
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| container_title | Journal of neuroimaging |
| container_volume | 17 |
| creator | Ferrara, Joseph M. Skeen, Mark B. Edwards, Nancy J. Gray, Linda Massey, E. Wayne |
| description | ABSTRACT
There is growing clinical evidence supporting a connection between copper deficiency and subacute combined degeneration. While nearly half of patients with copper deficiency myelopathy exhibit MRI abnormalities, signal changes are often ill‐defined in distribution. We report a patient with sensory ataxia and spastic paraplegia from copper deficiency whose MRI demonstrates abnormal signal restricted to the dorsal and lateral columns, providing clear radiological support of an association between hypocupremia and combined system degeneration. |
| doi_str_mv | 10.1111/j.1552-6569.2007.00126.x |
| format | Article |
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There is growing clinical evidence supporting a connection between copper deficiency and subacute combined degeneration. While nearly half of patients with copper deficiency myelopathy exhibit MRI abnormalities, signal changes are often ill‐defined in distribution. We report a patient with sensory ataxia and spastic paraplegia from copper deficiency whose MRI demonstrates abnormal signal restricted to the dorsal and lateral columns, providing clear radiological support of an association between hypocupremia and combined system degeneration.</description><identifier>ISSN: 1051-2284</identifier><identifier>EISSN: 1552-6569</identifier><identifier>DOI: 10.1111/j.1552-6569.2007.00126.x</identifier><identifier>PMID: 17894634</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>Aged ; Copper - deficiency ; Copper - therapeutic use ; Diagnosis, Differential ; Female ; Humans ; Magnetic Resonance Imaging ; myelopathy ; Neurodegenerative Diseases - diagnosis ; Neurodegenerative Diseases - drug therapy ; Spinal Cord Diseases - diagnosis ; Spinal Cord Diseases - drug therapy ; subacute combined degeneration</subject><ispartof>Journal of neuroimaging, 2007-10, Vol.17 (4), p.375-377</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3976-2930e354ac752c89d76cfbb826e4fe1d2a68b461bd596c5ba3157aa8151c13ae3</citedby><cites>FETCH-LOGICAL-c3976-2930e354ac752c89d76cfbb826e4fe1d2a68b461bd596c5ba3157aa8151c13ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1552-6569.2007.00126.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1552-6569.2007.00126.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17894634$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ferrara, Joseph M.</creatorcontrib><creatorcontrib>Skeen, Mark B.</creatorcontrib><creatorcontrib>Edwards, Nancy J.</creatorcontrib><creatorcontrib>Gray, Linda</creatorcontrib><creatorcontrib>Massey, E. Wayne</creatorcontrib><title>Subacute Combined Degeneration Due to Copper Deficiency</title><title>Journal of neuroimaging</title><addtitle>J Neuroimaging</addtitle><description>ABSTRACT
There is growing clinical evidence supporting a connection between copper deficiency and subacute combined degeneration. While nearly half of patients with copper deficiency myelopathy exhibit MRI abnormalities, signal changes are often ill‐defined in distribution. We report a patient with sensory ataxia and spastic paraplegia from copper deficiency whose MRI demonstrates abnormal signal restricted to the dorsal and lateral columns, providing clear radiological support of an association between hypocupremia and combined system degeneration.</description><subject>Aged</subject><subject>Copper - deficiency</subject><subject>Copper - therapeutic use</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>myelopathy</subject><subject>Neurodegenerative Diseases - diagnosis</subject><subject>Neurodegenerative Diseases - drug therapy</subject><subject>Spinal Cord Diseases - diagnosis</subject><subject>Spinal Cord Diseases - drug therapy</subject><subject>subacute combined degeneration</subject><issn>1051-2284</issn><issn>1552-6569</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1Lw0AQhhdRbK3-BcnJW-LOfmUDXqR-U-xBPS-7m4mk5Mukwfbfm9iiR53LDLzPzMBDSAA0gqEuVxFIyUIlVRIxSuOIUmAq2hyQ6U9wOMxUQsiYFhNy0nUrShkIxo_JBGKdCMXFlMQvvbO-X2Mwr0uXV5gGN_iOFbZ2nddVcNNjsK6HsGmwHaIs9zlWfntKjjJbdHi27zPydnf7On8IF8v7x_n1IvQ8iVXIEk6RS2F9LJnXSRornzmnmUKRIaTMKu2EApfKRHnpLAcZW6tBggdukc_Ixe5u09YfPXZrU-adx6KwFdZ9Z5TmIBSFP0EGnANnagD1DvRt3XUtZqZp89K2WwPUjHbNyowSzSjRjHbNt12zGVbP9z96V2L6u7jXOQBXO-AzL3D778Pmafk8DPwL7aeGvA</recordid><startdate>200710</startdate><enddate>200710</enddate><creator>Ferrara, Joseph M.</creator><creator>Skeen, Mark B.</creator><creator>Edwards, Nancy J.</creator><creator>Gray, Linda</creator><creator>Massey, E. Wayne</creator><general>Blackwell Publishing Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>200710</creationdate><title>Subacute Combined Degeneration Due to Copper Deficiency</title><author>Ferrara, Joseph M. ; Skeen, Mark B. ; Edwards, Nancy J. ; Gray, Linda ; Massey, E. Wayne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3976-2930e354ac752c89d76cfbb826e4fe1d2a68b461bd596c5ba3157aa8151c13ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Aged</topic><topic>Copper - deficiency</topic><topic>Copper - therapeutic use</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>myelopathy</topic><topic>Neurodegenerative Diseases - diagnosis</topic><topic>Neurodegenerative Diseases - drug therapy</topic><topic>Spinal Cord Diseases - diagnosis</topic><topic>Spinal Cord Diseases - drug therapy</topic><topic>subacute combined degeneration</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ferrara, Joseph M.</creatorcontrib><creatorcontrib>Skeen, Mark B.</creatorcontrib><creatorcontrib>Edwards, Nancy J.</creatorcontrib><creatorcontrib>Gray, Linda</creatorcontrib><creatorcontrib>Massey, E. Wayne</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroimaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ferrara, Joseph M.</au><au>Skeen, Mark B.</au><au>Edwards, Nancy J.</au><au>Gray, Linda</au><au>Massey, E. Wayne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Subacute Combined Degeneration Due to Copper Deficiency</atitle><jtitle>Journal of neuroimaging</jtitle><addtitle>J Neuroimaging</addtitle><date>2007-10</date><risdate>2007</risdate><volume>17</volume><issue>4</issue><spage>375</spage><epage>377</epage><pages>375-377</pages><issn>1051-2284</issn><eissn>1552-6569</eissn><abstract>ABSTRACT
There is growing clinical evidence supporting a connection between copper deficiency and subacute combined degeneration. While nearly half of patients with copper deficiency myelopathy exhibit MRI abnormalities, signal changes are often ill‐defined in distribution. We report a patient with sensory ataxia and spastic paraplegia from copper deficiency whose MRI demonstrates abnormal signal restricted to the dorsal and lateral columns, providing clear radiological support of an association between hypocupremia and combined system degeneration.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>17894634</pmid><doi>10.1111/j.1552-6569.2007.00126.x</doi><tpages>3</tpages></addata></record> |
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| ispartof | Journal of neuroimaging, 2007-10, Vol.17 (4), p.375-377 |
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| language | eng |
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| source | MEDLINE; Wiley Journals |
| subjects | Aged Copper - deficiency Copper - therapeutic use Diagnosis, Differential Female Humans Magnetic Resonance Imaging myelopathy Neurodegenerative Diseases - diagnosis Neurodegenerative Diseases - drug therapy Spinal Cord Diseases - diagnosis Spinal Cord Diseases - drug therapy subacute combined degeneration |
| title | Subacute Combined Degeneration Due to Copper Deficiency |
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