Pravastatin Reduces Myocardial Infarct Size Via Increasing Protein Kinase C-Dependent Nitric Oxide, Decreasing Oxyradicals and Opening the Mitochondrial Adenosine Triphosphate-Sensitive Potassium Channels in Rabbits

Background Statins reportedly protect against myocardial infarction, but the precise mechanism is unclear. Methods and Results Rabbits underwent 30 min of coronary occlusion followed by 48 h of reperfusion. Pravastatin (1 or 5 mg/kg) or saline was intravenously administered 10 min before ischemia. P...

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Veröffentlicht in:	Circulation Journal 2007, Vol.71(10), pp.1622-1628
Hauptverfasser:	Bao, Narentuoya, Minatoguchi, Shinya, Kobayashi, Hiroyuki, Yasuda, Shinji, Kawamura, Itta, Iwasa, Masamitsu, Yamaki, Takahiko, Sumi, Syohei, Misao, Yu, Arai, Masazumi, Nishigaki, Kazuhiko, Takemura, Genzou, Fujiwara, Takako, Fujiwara, Hisayoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Pressure - drug effects Disease Models, Animal Dose-Response Relationship, Drug Heart Rate - drug effects Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Infarct size Ischemic Preconditioning, Myocardial - methods KATP Channels - metabolism Male Mitochondria, Heart - metabolism Mitochondrial KATP channel Myocardial Infarction - pathology Myocardial Infarction - prevention & control Nitric oxide Nitric Oxide - metabolism Pravastatin Pravastatin - pharmacology Protein kinase C Protein Kinase C - metabolism Rabbits Reactive Oxygen Species - metabolism Superoxides - metabolism
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