Pubertal development in obese children and adolescents
Objective: To investigate clinical and laboratory markers of pubertal development in a large sample of obese children and adolescents. Methods: Analysis of parameters of sexual maturation in 1232 obese individuals (582 boys) aged 6–18 years (mean 13.0±2.42 years). Clinical evaluation of pubertal sta...
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| Veröffentlicht in: | International Journal of Obesity 2007-10, Vol.31 (10), p.1509-1519 |
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| container_title | International Journal of Obesity |
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| creator | Denzer, C Weibel, A Muche, R Karges, B Sorgo, W Wabitsch, M |
| description | Objective:
To investigate clinical and laboratory markers of pubertal development in a large sample of obese children and adolescents.
Methods:
Analysis of parameters of sexual maturation in 1232 obese individuals (582 boys) aged 6–18 years (mean 13.0±2.42 years). Clinical evaluation of pubertal stage and determination of bone age in a subset (227 patients).
Results:
Mean Height – standard deviation scores (height–SDS) was positive during childhood and reached zero approximately at age 14 years followed by a turn to negative mean height–SDS in both genders. Accordingly, bone age was accelerated until age 14. No significant differences in average time points of occurrence of pubic hair stages PH 2 to PH 4 in boys and PH 2 to PH 5 in girls were observed as compared to references of the First Zurich Longitudinal Study. In girls, breast stage B 3 was reached earlier (11.6 vs 12.2 years,
P
=0.03). In boys, mean volume of testis revealed no significant deviation from reference. Mean dehydroepiandrosterone sulfate (DHEAS) levels were elevated in boys (within age ranges 8–10 years and 12–16 years,
P |
| doi_str_mv | 10.1038/sj.ijo.0803691 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_68314256</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A188792711</galeid><sourcerecordid>A188792711</sourcerecordid><originalsourceid>FETCH-LOGICAL-c550t-1a2bd1badbd5c15124dca52a2052e48e49791529cf470433c0bb19b1da4de31d3</originalsourceid><addsrcrecordid>eNp1kc1v1DAQxS0Eokvhyg0UgegtW48TO86xqviSKsEBzpZjT7qOvPZiJ0j897jawAIq8sGS5_fezPgR8hzoFmgjL_O0dVPcUkkb0cMDsoG2EzVv--4h2dCGdjXlgp-RJzlPlFLOKXtMzqATvKFCbIj4vAyYZu0ri9_Rx8Mew1y5UMUBM1Zm57xNGCodbKVt9JhNAfJT8mjUPuOz9T4nX9-9_XL9ob759P7j9dVNbUqnuQbNBguDtoPlBjiw1hrNmWaUM2wlljF74Kw3Y9vRtmkMHQboB7C6tdiAbc7JxdH3kOK3BfOs9q5M4L0OGJeshGygZVwU8NU_4BSXFMpsikHPmOioLNDrI3SrPSoXxjgnbe4c1RVI2fWsAyjU9h6qHIt7Z2LA0ZX3vwQXfwh2qP28y9Evs4sh3-tsUsw54agOye11-qGAqrs4VZ5UiVOtcRbBy3WrZdijPeFrfgV4swI6G-3HpINx-cT1VHZSssJdHrlcSuEW0-l7_tv6xVER9Lwk_G35q_4TYBy-uQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>219226708</pqid></control><display><type>article</type><title>Pubertal development in obese children and adolescents</title><source>MEDLINE</source><source>Nature</source><source>SpringerNature Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Denzer, C ; Weibel, A ; Muche, R ; Karges, B ; Sorgo, W ; Wabitsch, M</creator><creatorcontrib>Denzer, C ; Weibel, A ; Muche, R ; Karges, B ; Sorgo, W ; Wabitsch, M</creatorcontrib><description>Objective:
To investigate clinical and laboratory markers of pubertal development in a large sample of obese children and adolescents.
Methods:
Analysis of parameters of sexual maturation in 1232 obese individuals (582 boys) aged 6–18 years (mean 13.0±2.42 years). Clinical evaluation of pubertal stage and determination of bone age in a subset (227 patients).
Results:
Mean Height – standard deviation scores (height–SDS) was positive during childhood and reached zero approximately at age 14 years followed by a turn to negative mean height–SDS in both genders. Accordingly, bone age was accelerated until age 14. No significant differences in average time points of occurrence of pubic hair stages PH 2 to PH 4 in boys and PH 2 to PH 5 in girls were observed as compared to references of the First Zurich Longitudinal Study. In girls, breast stage B 3 was reached earlier (11.6 vs 12.2 years,
P
=0.03). In boys, mean volume of testis revealed no significant deviation from reference. Mean dehydroepiandrosterone sulfate (DHEAS) levels were elevated in boys (within age ranges 8–10 years and 12–16 years,
P
<0.02) and in girls (within age ranges 6–8 years and 12–18 years,
P
<0.005) and mean testosterone levels in boys >12 years were lower as compared to reference ranges (all
P
-values <0.0001).
Conclusion:
The study data suggest normal development of pubarche and gonadarche in obese German boys and normal timing of pubarche in girls. Breast development in obese girls seems to be slightly advanced. In obese boys, an obvious dissociation of clinical and laboratory parameters of pubertal development was observed. Despite significantly increased height–SDS and increased DHEAS levels, gonadal development was normal and testosterone levels were decreased. Elevated DHEAS levels in both genders may contribute to the acceleration of bone maturation, a lower final body height and could increase cardiovascular risk.</description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/sj.ijo.0803691</identifier><identifier>PMID: 17653066</identifier><identifier>CODEN: IJOBDP</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adolescent ; Adolescents ; Anthropometry ; Biological and medical sciences ; Body height ; Body mass index ; Bone Development - physiology ; Child ; Children ; Complications and side effects ; Epidemiology ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; General aspects ; Hair ; Health Promotion and Disease Prevention ; Health risks ; Humans ; Internal Medicine ; Longitudinal studies ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Obesity ; Obesity - physiopathology ; Obesity in children ; pediatric-highlight ; Physiological aspects ; Puberty ; Puberty - physiology ; Public Health ; Sex Factors ; Sexual Maturation - physiology ; Standard deviation ; Sulfates ; Teenagers ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>International Journal of Obesity, 2007-10, Vol.31 (10), p.1509-1519</ispartof><rights>Springer Nature Limited 2007</rights><rights>2008 INIST-CNRS</rights><rights>COPYRIGHT 2007 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Oct 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c550t-1a2bd1badbd5c15124dca52a2052e48e49791529cf470433c0bb19b1da4de31d3</citedby><cites>FETCH-LOGICAL-c550t-1a2bd1badbd5c15124dca52a2052e48e49791529cf470433c0bb19b1da4de31d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.ijo.0803691$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.ijo.0803691$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,2727,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19087882$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17653066$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Denzer, C</creatorcontrib><creatorcontrib>Weibel, A</creatorcontrib><creatorcontrib>Muche, R</creatorcontrib><creatorcontrib>Karges, B</creatorcontrib><creatorcontrib>Sorgo, W</creatorcontrib><creatorcontrib>Wabitsch, M</creatorcontrib><title>Pubertal development in obese children and adolescents</title><title>International Journal of Obesity</title><addtitle>Int J Obes</addtitle><addtitle>Int J Obes (Lond)</addtitle><description>Objective:
To investigate clinical and laboratory markers of pubertal development in a large sample of obese children and adolescents.
Methods:
Analysis of parameters of sexual maturation in 1232 obese individuals (582 boys) aged 6–18 years (mean 13.0±2.42 years). Clinical evaluation of pubertal stage and determination of bone age in a subset (227 patients).
Results:
Mean Height – standard deviation scores (height–SDS) was positive during childhood and reached zero approximately at age 14 years followed by a turn to negative mean height–SDS in both genders. Accordingly, bone age was accelerated until age 14. No significant differences in average time points of occurrence of pubic hair stages PH 2 to PH 4 in boys and PH 2 to PH 5 in girls were observed as compared to references of the First Zurich Longitudinal Study. In girls, breast stage B 3 was reached earlier (11.6 vs 12.2 years,
P
=0.03). In boys, mean volume of testis revealed no significant deviation from reference. Mean dehydroepiandrosterone sulfate (DHEAS) levels were elevated in boys (within age ranges 8–10 years and 12–16 years,
P
<0.02) and in girls (within age ranges 6–8 years and 12–18 years,
P
<0.005) and mean testosterone levels in boys >12 years were lower as compared to reference ranges (all
P
-values <0.0001).
Conclusion:
The study data suggest normal development of pubarche and gonadarche in obese German boys and normal timing of pubarche in girls. Breast development in obese girls seems to be slightly advanced. In obese boys, an obvious dissociation of clinical and laboratory parameters of pubertal development was observed. Despite significantly increased height–SDS and increased DHEAS levels, gonadal development was normal and testosterone levels were decreased. Elevated DHEAS levels in both genders may contribute to the acceleration of bone maturation, a lower final body height and could increase cardiovascular risk.</description><subject>Adolescent</subject><subject>Adolescents</subject><subject>Anthropometry</subject><subject>Biological and medical sciences</subject><subject>Body height</subject><subject>Body mass index</subject><subject>Bone Development - physiology</subject><subject>Child</subject><subject>Children</subject><subject>Complications and side effects</subject><subject>Epidemiology</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>Hair</subject><subject>Health Promotion and Disease Prevention</subject><subject>Health risks</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Longitudinal studies</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Obesity</subject><subject>Obesity - physiopathology</subject><subject>Obesity in children</subject><subject>pediatric-highlight</subject><subject>Physiological aspects</subject><subject>Puberty</subject><subject>Puberty - physiology</subject><subject>Public Health</subject><subject>Sex Factors</subject><subject>Sexual Maturation - physiology</subject><subject>Standard deviation</subject><subject>Sulfates</subject><subject>Teenagers</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0307-0565</issn><issn>1476-5497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kc1v1DAQxS0Eokvhyg0UgegtW48TO86xqviSKsEBzpZjT7qOvPZiJ0j897jawAIq8sGS5_fezPgR8hzoFmgjL_O0dVPcUkkb0cMDsoG2EzVv--4h2dCGdjXlgp-RJzlPlFLOKXtMzqATvKFCbIj4vAyYZu0ri9_Rx8Mew1y5UMUBM1Zm57xNGCodbKVt9JhNAfJT8mjUPuOz9T4nX9-9_XL9ob759P7j9dVNbUqnuQbNBguDtoPlBjiw1hrNmWaUM2wlljF74Kw3Y9vRtmkMHQboB7C6tdiAbc7JxdH3kOK3BfOs9q5M4L0OGJeshGygZVwU8NU_4BSXFMpsikHPmOioLNDrI3SrPSoXxjgnbe4c1RVI2fWsAyjU9h6qHIt7Z2LA0ZX3vwQXfwh2qP28y9Evs4sh3-tsUsw54agOye11-qGAqrs4VZ5UiVOtcRbBy3WrZdijPeFrfgV4swI6G-3HpINx-cT1VHZSssJdHrlcSuEW0-l7_tv6xVER9Lwk_G35q_4TYBy-uQ</recordid><startdate>20071001</startdate><enddate>20071001</enddate><creator>Denzer, C</creator><creator>Weibel, A</creator><creator>Muche, R</creator><creator>Karges, B</creator><creator>Sorgo, W</creator><creator>Wabitsch, M</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7TK</scope><scope>7TS</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20071001</creationdate><title>Pubertal development in obese children and adolescents</title><author>Denzer, C ; Weibel, A ; Muche, R ; Karges, B ; Sorgo, W ; Wabitsch, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c550t-1a2bd1badbd5c15124dca52a2052e48e49791529cf470433c0bb19b1da4de31d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>Adolescents</topic><topic>Anthropometry</topic><topic>Biological and medical sciences</topic><topic>Body height</topic><topic>Body mass index</topic><topic>Bone Development - physiology</topic><topic>Child</topic><topic>Children</topic><topic>Complications and side effects</topic><topic>Epidemiology</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects</topic><topic>Hair</topic><topic>Health Promotion and Disease Prevention</topic><topic>Health risks</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Longitudinal studies</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Obesity</topic><topic>Obesity - physiopathology</topic><topic>Obesity in children</topic><topic>pediatric-highlight</topic><topic>Physiological aspects</topic><topic>Puberty</topic><topic>Puberty - physiology</topic><topic>Public Health</topic><topic>Sex Factors</topic><topic>Sexual Maturation - physiology</topic><topic>Standard deviation</topic><topic>Sulfates</topic><topic>Teenagers</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Denzer, C</creatorcontrib><creatorcontrib>Weibel, A</creatorcontrib><creatorcontrib>Muche, R</creatorcontrib><creatorcontrib>Karges, B</creatorcontrib><creatorcontrib>Sorgo, W</creatorcontrib><creatorcontrib>Wabitsch, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>International Journal of Obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Denzer, C</au><au>Weibel, A</au><au>Muche, R</au><au>Karges, B</au><au>Sorgo, W</au><au>Wabitsch, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pubertal development in obese children and adolescents</atitle><jtitle>International Journal of Obesity</jtitle><stitle>Int J Obes</stitle><addtitle>Int J Obes (Lond)</addtitle><date>2007-10-01</date><risdate>2007</risdate><volume>31</volume><issue>10</issue><spage>1509</spage><epage>1519</epage><pages>1509-1519</pages><issn>0307-0565</issn><eissn>1476-5497</eissn><coden>IJOBDP</coden><abstract>Objective:
To investigate clinical and laboratory markers of pubertal development in a large sample of obese children and adolescents.
Methods:
Analysis of parameters of sexual maturation in 1232 obese individuals (582 boys) aged 6–18 years (mean 13.0±2.42 years). Clinical evaluation of pubertal stage and determination of bone age in a subset (227 patients).
Results:
Mean Height – standard deviation scores (height–SDS) was positive during childhood and reached zero approximately at age 14 years followed by a turn to negative mean height–SDS in both genders. Accordingly, bone age was accelerated until age 14. No significant differences in average time points of occurrence of pubic hair stages PH 2 to PH 4 in boys and PH 2 to PH 5 in girls were observed as compared to references of the First Zurich Longitudinal Study. In girls, breast stage B 3 was reached earlier (11.6 vs 12.2 years,
P
=0.03). In boys, mean volume of testis revealed no significant deviation from reference. Mean dehydroepiandrosterone sulfate (DHEAS) levels were elevated in boys (within age ranges 8–10 years and 12–16 years,
P
<0.02) and in girls (within age ranges 6–8 years and 12–18 years,
P
<0.005) and mean testosterone levels in boys >12 years were lower as compared to reference ranges (all
P
-values <0.0001).
Conclusion:
The study data suggest normal development of pubarche and gonadarche in obese German boys and normal timing of pubarche in girls. Breast development in obese girls seems to be slightly advanced. In obese boys, an obvious dissociation of clinical and laboratory parameters of pubertal development was observed. Despite significantly increased height–SDS and increased DHEAS levels, gonadal development was normal and testosterone levels were decreased. Elevated DHEAS levels in both genders may contribute to the acceleration of bone maturation, a lower final body height and could increase cardiovascular risk.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>17653066</pmid><doi>10.1038/sj.ijo.0803691</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | International Journal of Obesity, 2007-10, Vol.31 (10), p.1509-1519 |
| issn | 0307-0565 1476-5497 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68314256 |
| source | MEDLINE; Nature; SpringerNature Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Adolescents Anthropometry Biological and medical sciences Body height Body mass index Bone Development - physiology Child Children Complications and side effects Epidemiology Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology General aspects Hair Health Promotion and Disease Prevention Health risks Humans Internal Medicine Longitudinal studies Male Medical sciences Medicine Medicine & Public Health Metabolic Diseases Obesity Obesity - physiopathology Obesity in children pediatric-highlight Physiological aspects Puberty Puberty - physiology Public Health Sex Factors Sexual Maturation - physiology Standard deviation Sulfates Teenagers Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Pubertal development in obese children and adolescents |
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