The growth-inhibitory effects of tomatoes digested in vitro in colon adenocarcinoma cells occur through down regulation of cyclin D1, Bcl-2 and Bcl-xL

In the present study, we utilised an in vitro digestion procedure to deliver molecules contained in tomatoes to cultured cells and to analyse potential mechanisms underlying the antitumoural effects of tomatoes reported in the literature. Ripe tomatoes underwent in vitro simulated digestion and the...

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Veröffentlicht in:	British journal of nutrition 2007-10, Vol.98 (4), p.789-795
Hauptverfasser:	Palozza, Paola, Serini, Simona, Boninsegna, Alma, Bellovino, Diana, Lucarini, Massimo, Monastra, Giovanni, Gaetani, Sancia
Format:	Artikel
Sprache:	eng
Schlagworte:	adenocarcinoma antineoplastic agents Apoptosis bcl-2-Associated X Protein - metabolism Biological and medical sciences carotenoids Cell Cycle Cell Line, Tumor colon Colon cancer cells Colonic Neoplasms - metabolism Colonic Neoplasms - prevention & control colorectal neoplasms cultured cells Cyclin D1 - metabolism Digestion Down-Regulation Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology gene expression regulation HT29 Cells Humans In vitro digestion lycopene Lycopersicon esculentum - chemistry Male metabolic inhibitors Neoplasm Proteins - metabolism Proto-Oncogene Proteins c-bcl-2 - metabolism Tomatoes Vertebrates: anatomy and physiology, studies on body, several organs or systems
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