Cellular Sphingolipids Regulate Macrophage Apolipoprotein E Secretion

Macrophage-derived apolipoprotein E (apoE) in the vessel wall has important effects on the vessel-wall response to atherogenic injury. The current studies characterize a novel post-transcriptional pathway for the regulation of apoE secretion from macrophages. Treatment of J774 macrophages transfecte...

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Veröffentlicht in:	Biochemistry (Easton) 2007-10, Vol.46 (39), p.11196-11204
Hauptverfasser:	Lucic, Danijela, Huang, Zhi Hua, Gu, DeSheng, Subbaiah, Papasani V, Mazzone, Theodore
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apolipoproteins E - genetics Apolipoproteins E - metabolism Cell Line Ceramides - pharmacology Chromatography, Liquid Electrophoresis, Polyacrylamide Gel Humans Immunoprecipitation Macrophages - cytology Macrophages - drug effects Macrophages - metabolism Mass Spectrometry Sphingolipids - pharmacology Sphingomyelins - metabolism Time Factors Transfection
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