Natural aging, expression of fibrosis-related genes and collagen deposition in rat lung

Aging lung is characterized by morpho-structural modifications, including progressive fibrosis, that lead to an altered function. Here we provide a comprehensive description of lung collagen expression and metabolism during natural aging of rats. Peribronchial collagen increased significantly in the...

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Veröffentlicht in:	Experimental gerontology 2007-10, Vol.42 (10), p.1003-1011
Hauptverfasser:	Calabresi, Carmen, Arosio, Beatrice, Galimberti, Lorenza, Scanziani, Eugenio, Bergottini, Raffaella, Annoni, Giorgio, Vergani, Carlo
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - genetics Aging - metabolism Animals Collagen Collagen - genetics Collagen - metabolism Extracellular Matrix - metabolism Fibronectins - metabolism Fibrosis Gene Expression Regulation Lung Lung - metabolism Male Matrix metalloproteinases Matrix Metalloproteinases - physiology Pulmonary Fibrosis - genetics Pulmonary Fibrosis - metabolism Rats Rats, Sprague-Dawley Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger - genetics Tissue Inhibitor of Metalloproteinases - metabolism
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