Low-dose tenecteplase during cardiopulmonary resuscitation due to massive pulmonary embolism: a case report and review of previously reported cases
The case of a 29 year-old man who suffered a cardiac arrest due to a massive pulmonary embolism while he was undergoing surgical repair of a complex tibial plateau fracture is presented. After 70 min of unsuccessful cardiopulmonary resuscitation a bolus of 20 mg tenecteplase was given, with a return...
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| Veröffentlicht in: | Blood coagulation & fibrinolysis 2007-10, Vol.18 (7), p.691-694 |
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| creator | Hefer, David Václav Fred Munir, Aman Khouli, Hassan |
| description | The case of a 29 year-old man who suffered a cardiac arrest due to a massive pulmonary embolism while he was undergoing surgical repair of a complex tibial plateau fracture is presented. After 70 min of unsuccessful cardiopulmonary resuscitation a bolus of 20 mg tenecteplase was given, with a return of spontaneous circulation 2 min after administration of the drug. Pulmonary embolism was subsequently demonstrated on a pulmonary angiogram. To our knowledge this is the first report to show that the use of a low dose of tenecteplase might be useful to achieve the return of spontaneous circulation in the resuscitation of patients with cardiac arrest secondary to massive pulmonary embolism. Previously reported cases are reviewed. |
| doi_str_mv | 10.1097/MBC.0b013e3282a167a7 |
| format | Article |
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After 70 min of unsuccessful cardiopulmonary resuscitation a bolus of 20 mg tenecteplase was given, with a return of spontaneous circulation 2 min after administration of the drug. Pulmonary embolism was subsequently demonstrated on a pulmonary angiogram. To our knowledge this is the first report to show that the use of a low dose of tenecteplase might be useful to achieve the return of spontaneous circulation in the resuscitation of patients with cardiac arrest secondary to massive pulmonary embolism. Previously reported cases are reviewed.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood Circulation - drug effects</subject><subject>Blood coagulation. Blood cells</subject><subject>Cardiopulmonary Resuscitation</subject><subject>Fatal Outcome</subject><subject>Fibrinolytic Agents - administration & dosage</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heart Arrest - etiology</subject><subject>Heart Arrest - therapy</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Intraoperative Complications - drug therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Molecular and cellular biology</subject><subject>Platelet diseases and coagulopathies</subject><subject>Pulmonary Embolism - drug therapy</subject><subject>Pulmonary Embolism - etiology</subject><subject>Respiratory Insufficiency - etiology</subject><subject>Tibial Fractures - complications</subject><subject>Tibial Fractures - surgery</subject><subject>Tissue Plasminogen Activator - administration & dosage</subject><issn>0957-5235</issn><issn>1473-5733</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkctu1TAQhi0EoofCGyDkDezS-hLHCTt6xKXSQd3A2vJlQg1OHOykR32OvjBOG-lIrDzj-ea3Z36E3lJyQUknL79f7S-IIZQDZy3TtJFaPkM7WkteCcn5c7QjnZCVYFycoVc5_yaE8LqVL9EZlW1Xit0OPRzisXIxA55hBDvDFHRJ3JL8-AtbnZyP0xKGOOp0jxPkJVs_69nHsUClK-JB5-zvAJ8wGEwMPg8fsS4SRS7BFNOM9ehKeOfhiGOPpzWMSw73Wx3cI51foxe9DhnebOc5-vnl84_9t-pw8_V6_-lQWbYO5hy1RDfEGNHz3nVGdA1Q23Bmetc6w-tOMrAtFUC15bS3jTCuMZRbyUjf8XP04Ul3SvHvAnlWg88WQtAjlH-ppuXrpmkB6yfQpphzgl5NyQ9lUkWJWhFVzFD_m1Ha3m36ixnAnZq27Rfg_QbobHXokx6tzyeuo0S0NTm9f4xhhpT_hOUISd2CDvOtKrYSKhmtGCGSrln1eMP_Abwfp80</recordid><startdate>200710</startdate><enddate>200710</enddate><creator>Hefer, David Václav Fred</creator><creator>Munir, Aman</creator><creator>Khouli, Hassan</creator><general>Lippincott Williams & Wilkins, Inc</general><general>The Scientist</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200710</creationdate><title>Low-dose tenecteplase during cardiopulmonary resuscitation due to massive pulmonary embolism: a case report and review of previously reported cases</title><author>Hefer, David Václav Fred ; Munir, Aman ; Khouli, Hassan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2957-dd1c0a60bb5f3fd9b596e1c632bfd8db34972ec815e1ac31fc65bd6b13c720f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Blood Circulation - drug effects</topic><topic>Blood coagulation. Blood cells</topic><topic>Cardiopulmonary Resuscitation</topic><topic>Fatal Outcome</topic><topic>Fibrinolytic Agents - administration & dosage</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Heart Arrest - etiology</topic><topic>Heart Arrest - therapy</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Intraoperative Complications - drug therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Molecular and cellular biology</topic><topic>Platelet diseases and coagulopathies</topic><topic>Pulmonary Embolism - drug therapy</topic><topic>Pulmonary Embolism - etiology</topic><topic>Respiratory Insufficiency - etiology</topic><topic>Tibial Fractures - complications</topic><topic>Tibial Fractures - surgery</topic><topic>Tissue Plasminogen Activator - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hefer, David Václav Fred</creatorcontrib><creatorcontrib>Munir, Aman</creatorcontrib><creatorcontrib>Khouli, Hassan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Blood coagulation & fibrinolysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hefer, David Václav Fred</au><au>Munir, Aman</au><au>Khouli, Hassan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low-dose tenecteplase during cardiopulmonary resuscitation due to massive pulmonary embolism: a case report and review of previously reported cases</atitle><jtitle>Blood coagulation & fibrinolysis</jtitle><addtitle>Blood Coagul Fibrinolysis</addtitle><date>2007-10</date><risdate>2007</risdate><volume>18</volume><issue>7</issue><spage>691</spage><epage>694</epage><pages>691-694</pages><issn>0957-5235</issn><eissn>1473-5733</eissn><abstract>The case of a 29 year-old man who suffered a cardiac arrest due to a massive pulmonary embolism while he was undergoing surgical repair of a complex tibial plateau fracture is presented. After 70 min of unsuccessful cardiopulmonary resuscitation a bolus of 20 mg tenecteplase was given, with a return of spontaneous circulation 2 min after administration of the drug. Pulmonary embolism was subsequently demonstrated on a pulmonary angiogram. To our knowledge this is the first report to show that the use of a low dose of tenecteplase might be useful to achieve the return of spontaneous circulation in the resuscitation of patients with cardiac arrest secondary to massive pulmonary embolism. Previously reported cases are reviewed.</abstract><cop>Philadelphia, PA</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>17890959</pmid><doi>10.1097/MBC.0b013e3282a167a7</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Blood coagulation & fibrinolysis, 2007-10, Vol.18 (7), p.691-694 |
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| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Biological and medical sciences Blood Circulation - drug effects Blood coagulation. Blood cells Cardiopulmonary Resuscitation Fatal Outcome Fibrinolytic Agents - administration & dosage Fundamental and applied biological sciences. Psychology Heart Arrest - etiology Heart Arrest - therapy Hematologic and hematopoietic diseases Humans Intraoperative Complications - drug therapy Male Medical sciences Molecular and cellular biology Platelet diseases and coagulopathies Pulmonary Embolism - drug therapy Pulmonary Embolism - etiology Respiratory Insufficiency - etiology Tibial Fractures - complications Tibial Fractures - surgery Tissue Plasminogen Activator - administration & dosage |
| title | Low-dose tenecteplase during cardiopulmonary resuscitation due to massive pulmonary embolism: a case report and review of previously reported cases |
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