Rapid and improved determination of furan in baby foods and infant formulas by headspace GC/MS
Furan is a 5-membered ring compound with high volatility. The U.S. Food and Drug Administration (FDA) has recently published a report on the occurrence of furan in a large number of thermally processed foods. However, the FDA's analytical method, using standard curve addition, is not suitable f...
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| Veröffentlicht in: | Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi) 2007/08/25, Vol.48(4), pp.83-89 |
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| container_title | Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi) |
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| creator | Yoshida, I.(Japan Food Research Labs., Ibaraki, Osaka) Isagawa, S Kibune, N Hamano-Nagaoka, M Maitani, T |
| description | Furan is a 5-membered ring compound with high volatility. The U.S. Food and Drug Administration (FDA) has recently published a report on the occurrence of furan in a large number of thermally processed foods. However, the FDA's analytical method, using standard curve addition, is not suitable for high-throughput routine laboratory operations. We developed a rapid and improved method for determination of furan in foods by headspace GC/MS. Quantification was achieved by using an internal standard of dsub(4)-furan and an external calibration curve of furan normalized against the internal standard. The incubation temperature for equilibration was set at 60 deg C to avoid the formation of furan during analysis. The levels of furan in baby foods and infant formulas were determined with this method. Validation data showed good precision and accuracy. The LOD and LOQ were 0.2-0.5 ng/g and 0.5-2 ng/g for various food matrixes, respectively. The level of furan detected was in the range of 1.4 to 90 ng/g in baby foods and in the range of non-detectable to 36 ng/g in infant formulas. |
| doi_str_mv | 10.3358/shokueishi.48.83 |
| format | Article |
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The U.S. Food and Drug Administration (FDA) has recently published a report on the occurrence of furan in a large number of thermally processed foods. However, the FDA's analytical method, using standard curve addition, is not suitable for high-throughput routine laboratory operations. We developed a rapid and improved method for determination of furan in foods by headspace GC/MS. Quantification was achieved by using an internal standard of dsub(4)-furan and an external calibration curve of furan normalized against the internal standard. The incubation temperature for equilibration was set at 60 deg C to avoid the formation of furan during analysis. The levels of furan in baby foods and infant formulas were determined with this method. Validation data showed good precision and accuracy. The LOD and LOQ were 0.2-0.5 ng/g and 0.5-2 ng/g for various food matrixes, respectively. The level of furan detected was in the range of 1.4 to 90 ng/g in baby foods and in the range of non-detectable to 36 ng/g in infant formulas.</description><identifier>ISSN: 0015-6426</identifier><identifier>EISSN: 1882-1006</identifier><identifier>DOI: 10.3358/shokueishi.48.83</identifier><identifier>PMID: 17892001</identifier><language>eng</language><publisher>Japan: Japanese Society for Food Hygiene and Safety</publisher><subject>ALIMENT POUR NOURRISSON ; ALIMENTOS PARA NINOS ; ANALYTICAL METHODS ; baby food ; CHROMATOGRAPHIE EN PHASE GAZEUSE ; CROMATOGRAFIA DE GASES ; ESPECTROMETRIA DE MASAS ; furan ; FURANE ; FURANOS ; FURANS ; Furans - analysis ; GAS CHROMATOGRAPHY ; gas chromatography-mass spectrometry ; Gas Chromatography-Mass Spectrometry - methods ; headspace ; Infant Food - analysis ; INFANT FOODS ; infant formula ; Infant Formula - chemistry ; MASS SPECTROMETRY ; SPECTROMETRIE DE MASSE ; TECHNIQUE ANALYTIQUE ; TECNICAS ANALITICAS</subject><ispartof>Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi), 2007/08/25, Vol.48(4), pp.83-89</ispartof><rights>2007 Japanese Society for Food Hygiene and Safety</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c568t-f4c2a87138cf36757a3ec8787d4a36ef5188234114e71230ee25153dc5bb69ba3</citedby><cites>FETCH-LOGICAL-c568t-f4c2a87138cf36757a3ec8787d4a36ef5188234114e71230ee25153dc5bb69ba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17892001$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yoshida, I.(Japan Food Research Labs., Ibaraki, Osaka)</creatorcontrib><creatorcontrib>Isagawa, S</creatorcontrib><creatorcontrib>Kibune, N</creatorcontrib><creatorcontrib>Hamano-Nagaoka, M</creatorcontrib><creatorcontrib>Maitani, T</creatorcontrib><creatorcontrib>National Institute of Health Sciences</creatorcontrib><creatorcontrib>Japan Food Research Laboratories</creatorcontrib><title>Rapid and improved determination of furan in baby foods and infant formulas by headspace GC/MS</title><title>Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi)</title><addtitle>Food Hyg. Saf. Sci.</addtitle><description>Furan is a 5-membered ring compound with high volatility. The U.S. Food and Drug Administration (FDA) has recently published a report on the occurrence of furan in a large number of thermally processed foods. However, the FDA's analytical method, using standard curve addition, is not suitable for high-throughput routine laboratory operations. We developed a rapid and improved method for determination of furan in foods by headspace GC/MS. Quantification was achieved by using an internal standard of dsub(4)-furan and an external calibration curve of furan normalized against the internal standard. The incubation temperature for equilibration was set at 60 deg C to avoid the formation of furan during analysis. The levels of furan in baby foods and infant formulas were determined with this method. Validation data showed good precision and accuracy. The LOD and LOQ were 0.2-0.5 ng/g and 0.5-2 ng/g for various food matrixes, respectively. The level of furan detected was in the range of 1.4 to 90 ng/g in baby foods and in the range of non-detectable to 36 ng/g in infant formulas.</description><subject>ALIMENT POUR NOURRISSON</subject><subject>ALIMENTOS PARA NINOS</subject><subject>ANALYTICAL METHODS</subject><subject>baby food</subject><subject>CHROMATOGRAPHIE EN PHASE GAZEUSE</subject><subject>CROMATOGRAFIA DE GASES</subject><subject>ESPECTROMETRIA DE MASAS</subject><subject>furan</subject><subject>FURANE</subject><subject>FURANOS</subject><subject>FURANS</subject><subject>Furans - analysis</subject><subject>GAS CHROMATOGRAPHY</subject><subject>gas chromatography-mass spectrometry</subject><subject>Gas Chromatography-Mass Spectrometry - methods</subject><subject>headspace</subject><subject>Infant Food - analysis</subject><subject>INFANT FOODS</subject><subject>infant formula</subject><subject>Infant Formula - chemistry</subject><subject>MASS SPECTROMETRY</subject><subject>SPECTROMETRIE DE MASSE</subject><subject>TECHNIQUE ANALYTIQUE</subject><subject>TECNICAS ANALITICAS</subject><issn>0015-6426</issn><issn>1882-1006</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdUE1v1DAQtRCILoU7F5BP3LK1YztxjmhVFlARiI8r1sSZNF4Se2snSP33eJWFShw8I817857nEfKSs60QSl-lIfxa0KXBbaXeavGIbLjWZcEZqx6TDWNcFZUsqwvyLKVDHjLB9FNywWvdlBndkJ9f4eg6Cr6jbjrG8Bs72uGMcXIeZhc8DT3tlwieOk9baO9pH0KX1g3fg5_zIE7LCIlmcEDo0hEs0v3u6tO35-RJD2PCF-d-SX68u_6-e1_cfN5_2L29Kayq9Fz00pagay607UVVqxoEWl3rupMgKuzV6SohOZdY81IwxFJxJTqr2rZqWhCX5M2qm0-4WzDNZnLJ4jiCx7AkU2nBmS5VJrKVaGNIKWJvjtFNEO8NZ-aUqXnI1EhttMgrr8_aSzth97BwDjET9isho87CGPzoPJpDWKLPRxsM6pTZYDK7NoxJzWRuPD8tcmlYKRpVN2VWul6VDmmGW_xnBXF2dsT__ibXkjX-4naAaNBnnVerTg_BwG10yXz8cnLPZqXQ4g88OK2C</recordid><startdate>20070801</startdate><enddate>20070801</enddate><creator>Yoshida, I.(Japan Food Research Labs., Ibaraki, Osaka)</creator><creator>Isagawa, S</creator><creator>Kibune, N</creator><creator>Hamano-Nagaoka, M</creator><creator>Maitani, T</creator><general>Japanese Society for Food Hygiene and Safety</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070801</creationdate><title>Rapid and improved determination of furan in baby foods and infant formulas by headspace GC/MS</title><author>Yoshida, I.(Japan Food Research Labs., Ibaraki, Osaka) ; Isagawa, S ; Kibune, N ; Hamano-Nagaoka, M ; Maitani, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c568t-f4c2a87138cf36757a3ec8787d4a36ef5188234114e71230ee25153dc5bb69ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>ALIMENT POUR NOURRISSON</topic><topic>ALIMENTOS PARA NINOS</topic><topic>ANALYTICAL METHODS</topic><topic>baby food</topic><topic>CHROMATOGRAPHIE EN PHASE GAZEUSE</topic><topic>CROMATOGRAFIA DE GASES</topic><topic>ESPECTROMETRIA DE MASAS</topic><topic>furan</topic><topic>FURANE</topic><topic>FURANOS</topic><topic>FURANS</topic><topic>Furans - analysis</topic><topic>GAS CHROMATOGRAPHY</topic><topic>gas chromatography-mass spectrometry</topic><topic>Gas Chromatography-Mass Spectrometry - methods</topic><topic>headspace</topic><topic>Infant Food - analysis</topic><topic>INFANT FOODS</topic><topic>infant formula</topic><topic>Infant Formula - chemistry</topic><topic>MASS SPECTROMETRY</topic><topic>SPECTROMETRIE DE MASSE</topic><topic>TECHNIQUE ANALYTIQUE</topic><topic>TECNICAS ANALITICAS</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yoshida, I.(Japan Food Research Labs., Ibaraki, Osaka)</creatorcontrib><creatorcontrib>Isagawa, S</creatorcontrib><creatorcontrib>Kibune, N</creatorcontrib><creatorcontrib>Hamano-Nagaoka, M</creatorcontrib><creatorcontrib>Maitani, T</creatorcontrib><creatorcontrib>National Institute of Health Sciences</creatorcontrib><creatorcontrib>Japan Food Research Laboratories</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yoshida, I.(Japan Food Research Labs., Ibaraki, Osaka)</au><au>Isagawa, S</au><au>Kibune, N</au><au>Hamano-Nagaoka, M</au><au>Maitani, T</au><aucorp>National Institute of Health Sciences</aucorp><aucorp>Japan Food Research Laboratories</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rapid and improved determination of furan in baby foods and infant formulas by headspace GC/MS</atitle><jtitle>Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi)</jtitle><addtitle>Food Hyg. 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The levels of furan in baby foods and infant formulas were determined with this method. Validation data showed good precision and accuracy. The LOD and LOQ were 0.2-0.5 ng/g and 0.5-2 ng/g for various food matrixes, respectively. The level of furan detected was in the range of 1.4 to 90 ng/g in baby foods and in the range of non-detectable to 36 ng/g in infant formulas.</abstract><cop>Japan</cop><pub>Japanese Society for Food Hygiene and Safety</pub><pmid>17892001</pmid><doi>10.3358/shokueishi.48.83</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi), 2007/08/25, Vol.48(4), pp.83-89 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; AgriKnowledge（アグリナレッジ）AGROLib |
| subjects | ALIMENT POUR NOURRISSON ALIMENTOS PARA NINOS ANALYTICAL METHODS baby food CHROMATOGRAPHIE EN PHASE GAZEUSE CROMATOGRAFIA DE GASES ESPECTROMETRIA DE MASAS furan FURANE FURANOS FURANS Furans - analysis GAS CHROMATOGRAPHY gas chromatography-mass spectrometry Gas Chromatography-Mass Spectrometry - methods headspace Infant Food - analysis INFANT FOODS infant formula Infant Formula - chemistry MASS SPECTROMETRY SPECTROMETRIE DE MASSE TECHNIQUE ANALYTIQUE TECNICAS ANALITICAS |
| title | Rapid and improved determination of furan in baby foods and infant formulas by headspace GC/MS |
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