High-altitude adaptations in vertebrate hemoglobins

Abstract Vertebrates at high altitude are subjected to hypoxic conditions that challenge aerobic metabolism. O2 transport from the respiratory surfaces to tissues requires matching between the O2 loading and unloading tensions and the O2 -affinity of blood, which is an integrated function of hemoglo...

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Veröffentlicht in:	Respiratory physiology & neurobiology 2007-09, Vol.158 (2), p.132-142
1. Verfasser:	Weber, Roy E
Format:	Artikel
Sprache:	eng
Schlagworte:	Acclimatization - physiology Allosteric interactions Altitude Amino acid substitutions Amphibians Animals Atmospheric Pressure Birds Body Temperature Regulation - physiology Erythrocytes Hemoglobin Hemoglobins - chemistry Hemoglobins - metabolism High altitude Humans Mammals Medical Education Molecular adaptations Oxygen - blood Oxygen-affinity Protein Conformation Pulmonary Gas Exchange Pulmonary/Respiratory Reptiles Structure-Activity Relationship Vertebrates - physiology
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