Iron oxide particle-enhanced MRI suggests variability of brain inflammation at early stages after ischemic stroke
Inflammation contributes to brain damage caused by ischemic stroke. Ultrasmall superparamagnetic iron oxide (USPIO)-enhanced MRI allows noninvasive monitoring of macrophage recruitment into ischemic brain lesions. In this study, we determined the extent of USPIO enhancement during early stages of is...
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| Veröffentlicht in: | Stroke (1970) 2007-10, Vol.38 (10), p.2733-2737 |
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| container_title | Stroke (1970) |
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| creator | SALEH, Andreas SCHROETER, Michael RINGELSTEIN, Adrian HARTUNG, Hans-Peter SIEBLER, Mario MÖDDER, Ulrich JANDER, Sebastian |
| description | Inflammation contributes to brain damage caused by ischemic stroke. Ultrasmall superparamagnetic iron oxide (USPIO)-enhanced MRI allows noninvasive monitoring of macrophage recruitment into ischemic brain lesions. In this study, we determined the extent of USPIO enhancement during early stages of ischemic stroke.
Twelve consecutive patients with typical clinical signs of stroke underwent multimodal stroke imaging at 1.5-T within 24 hours of symptom onset. They received intravenous USPIO (ferumoxtran) infusion at 26 to 96 hours (mean, 44 hours) after stroke. A total of four follow-up MRI scans were performed 24 to 36 hours, 48 to 72 hours, 7 to 8 days, and 10 to 11 days after USPIO infusion.
Nine patients were included in the final analysis. Parenchymal USPIO enhancement occurred in 3 of 9 analyzed patients and was mainly evident on T1-weighted spin-echo images. USPIO-dependent signal changes were spatially heterogeneous, reflecting the distinct patterns of hematogenous macrophage infiltration in different lesion types.
Our findings suggest a variable extent and distribution of macrophage infiltration into early ischemic stroke lesions. USPIO-enhanced MRI may help to more specifically target antiinflammatory therapy in patients with stroke. |
| doi_str_mv | 10.1161/strokeaha.107.481788 |
| format | Article |
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Twelve consecutive patients with typical clinical signs of stroke underwent multimodal stroke imaging at 1.5-T within 24 hours of symptom onset. They received intravenous USPIO (ferumoxtran) infusion at 26 to 96 hours (mean, 44 hours) after stroke. A total of four follow-up MRI scans were performed 24 to 36 hours, 48 to 72 hours, 7 to 8 days, and 10 to 11 days after USPIO infusion.
Nine patients were included in the final analysis. Parenchymal USPIO enhancement occurred in 3 of 9 analyzed patients and was mainly evident on T1-weighted spin-echo images. USPIO-dependent signal changes were spatially heterogeneous, reflecting the distinct patterns of hematogenous macrophage infiltration in different lesion types.
Our findings suggest a variable extent and distribution of macrophage infiltration into early ischemic stroke lesions. USPIO-enhanced MRI may help to more specifically target antiinflammatory therapy in patients with stroke.</description><identifier>ISSN: 0039-2499</identifier><identifier>EISSN: 1524-4628</identifier><identifier>DOI: 10.1161/strokeaha.107.481788</identifier><identifier>PMID: 17717318</identifier><identifier>CODEN: SJCCA7</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Blood. Blood coagulation. Reticuloendothelial system ; Brain Ischemia - immunology ; Brain Ischemia - pathology ; Contrast Media ; Dextrans ; Early Diagnosis ; Encephalitis - immunology ; Encephalitis - pathology ; Female ; Ferrosoferric Oxide ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Humans ; Iron ; Macrophages - pathology ; Magnetic Resonance Imaging - methods ; Magnetite Nanoparticles ; Male ; Medical sciences ; Middle Aged ; Nervous system (semeiology, syndromes) ; Neurology ; Oxides ; Pharmacology. Drug treatments ; Stroke - immunology ; Stroke - pathology ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Stroke (1970), 2007-10, Vol.38 (10), p.2733-2737</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c566t-6c480ad8f506e6bfcf761d0f86ca7d5c373711ded70abf1fabb70a80dd728eb3</citedby><cites>FETCH-LOGICAL-c566t-6c480ad8f506e6bfcf761d0f86ca7d5c373711ded70abf1fabb70a80dd728eb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19127671$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17717318$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SALEH, Andreas</creatorcontrib><creatorcontrib>SCHROETER, Michael</creatorcontrib><creatorcontrib>RINGELSTEIN, Adrian</creatorcontrib><creatorcontrib>HARTUNG, Hans-Peter</creatorcontrib><creatorcontrib>SIEBLER, Mario</creatorcontrib><creatorcontrib>MÖDDER, Ulrich</creatorcontrib><creatorcontrib>JANDER, Sebastian</creatorcontrib><title>Iron oxide particle-enhanced MRI suggests variability of brain inflammation at early stages after ischemic stroke</title><title>Stroke (1970)</title><addtitle>Stroke</addtitle><description>Inflammation contributes to brain damage caused by ischemic stroke. Ultrasmall superparamagnetic iron oxide (USPIO)-enhanced MRI allows noninvasive monitoring of macrophage recruitment into ischemic brain lesions. In this study, we determined the extent of USPIO enhancement during early stages of ischemic stroke.
Twelve consecutive patients with typical clinical signs of stroke underwent multimodal stroke imaging at 1.5-T within 24 hours of symptom onset. They received intravenous USPIO (ferumoxtran) infusion at 26 to 96 hours (mean, 44 hours) after stroke. A total of four follow-up MRI scans were performed 24 to 36 hours, 48 to 72 hours, 7 to 8 days, and 10 to 11 days after USPIO infusion.
Nine patients were included in the final analysis. Parenchymal USPIO enhancement occurred in 3 of 9 analyzed patients and was mainly evident on T1-weighted spin-echo images. USPIO-dependent signal changes were spatially heterogeneous, reflecting the distinct patterns of hematogenous macrophage infiltration in different lesion types.
Our findings suggest a variable extent and distribution of macrophage infiltration into early ischemic stroke lesions. USPIO-enhanced MRI may help to more specifically target antiinflammatory therapy in patients with stroke.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Blood. Blood coagulation. Reticuloendothelial system</subject><subject>Brain Ischemia - immunology</subject><subject>Brain Ischemia - pathology</subject><subject>Contrast Media</subject><subject>Dextrans</subject><subject>Early Diagnosis</subject><subject>Encephalitis - immunology</subject><subject>Encephalitis - pathology</subject><subject>Female</subject><subject>Ferrosoferric Oxide</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Humans</subject><subject>Iron</subject><subject>Macrophages - pathology</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Magnetite Nanoparticles</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Oxides</subject><subject>Pharmacology. Drug treatments</subject><subject>Stroke - immunology</subject><subject>Stroke - pathology</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0039-2499</issn><issn>1524-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUlPG0EQhVsRUTDLP4hQX-A2TtcsvRwtRMAChER8H9X0gjvMYrrbEf73aWRLHDlVqfS9p6p6hPwENgfg8CumML1aXOMcmJjXEoSU38gMmrIual7KIzJjrFJFWSt1TE5i_MsYKyvZ_CDHIASICuSMvC3DNNLp3RtLNxiS170t7LjGUVtDH5-XNG5fXmxMkf7D4LHzvU87OjnaBfQj9aPrcRgw-WyDiVoM_Y7GhFlD0SUbqI96bQev6X7jM_LdYR_t-aGektXvm9X1XfHwdLu8XjwUuuE8FVzXkqGRrmHc8s5pJzgY5iTXKEyjK1EJAGONYNg5cNh1uZPMGFFK21Wn5GpvuwnT2zYf0A55Edv3ONppG1suK6akUl-CJSuVAgUZrPegDlOMwbp2E_yAYdcCaz8iaf-snp_ubxZ3izwR7T6SLLs4-G-7wZpP0SGDDFweAIwaexfy73385BSUgguo_gOT55jj</recordid><startdate>20071001</startdate><enddate>20071001</enddate><creator>SALEH, Andreas</creator><creator>SCHROETER, Michael</creator><creator>RINGELSTEIN, Adrian</creator><creator>HARTUNG, Hans-Peter</creator><creator>SIEBLER, Mario</creator><creator>MÖDDER, Ulrich</creator><creator>JANDER, Sebastian</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20071001</creationdate><title>Iron oxide particle-enhanced MRI suggests variability of brain inflammation at early stages after ischemic stroke</title><author>SALEH, Andreas ; SCHROETER, Michael ; RINGELSTEIN, Adrian ; HARTUNG, Hans-Peter ; SIEBLER, Mario ; MÖDDER, Ulrich ; JANDER, Sebastian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c566t-6c480ad8f506e6bfcf761d0f86ca7d5c373711ded70abf1fabb70a80dd728eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Blood. Blood coagulation. Reticuloendothelial system</topic><topic>Brain Ischemia - immunology</topic><topic>Brain Ischemia - pathology</topic><topic>Contrast Media</topic><topic>Dextrans</topic><topic>Early Diagnosis</topic><topic>Encephalitis - immunology</topic><topic>Encephalitis - pathology</topic><topic>Female</topic><topic>Ferrosoferric Oxide</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Humans</topic><topic>Iron</topic><topic>Macrophages - pathology</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Magnetite Nanoparticles</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Oxides</topic><topic>Pharmacology. Drug treatments</topic><topic>Stroke - immunology</topic><topic>Stroke - pathology</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SALEH, Andreas</creatorcontrib><creatorcontrib>SCHROETER, Michael</creatorcontrib><creatorcontrib>RINGELSTEIN, Adrian</creatorcontrib><creatorcontrib>HARTUNG, Hans-Peter</creatorcontrib><creatorcontrib>SIEBLER, Mario</creatorcontrib><creatorcontrib>MÖDDER, Ulrich</creatorcontrib><creatorcontrib>JANDER, Sebastian</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Stroke (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SALEH, Andreas</au><au>SCHROETER, Michael</au><au>RINGELSTEIN, Adrian</au><au>HARTUNG, Hans-Peter</au><au>SIEBLER, Mario</au><au>MÖDDER, Ulrich</au><au>JANDER, Sebastian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Iron oxide particle-enhanced MRI suggests variability of brain inflammation at early stages after ischemic stroke</atitle><jtitle>Stroke (1970)</jtitle><addtitle>Stroke</addtitle><date>2007-10-01</date><risdate>2007</risdate><volume>38</volume><issue>10</issue><spage>2733</spage><epage>2737</epage><pages>2733-2737</pages><issn>0039-2499</issn><eissn>1524-4628</eissn><coden>SJCCA7</coden><abstract>Inflammation contributes to brain damage caused by ischemic stroke. Ultrasmall superparamagnetic iron oxide (USPIO)-enhanced MRI allows noninvasive monitoring of macrophage recruitment into ischemic brain lesions. In this study, we determined the extent of USPIO enhancement during early stages of ischemic stroke.
Twelve consecutive patients with typical clinical signs of stroke underwent multimodal stroke imaging at 1.5-T within 24 hours of symptom onset. They received intravenous USPIO (ferumoxtran) infusion at 26 to 96 hours (mean, 44 hours) after stroke. A total of four follow-up MRI scans were performed 24 to 36 hours, 48 to 72 hours, 7 to 8 days, and 10 to 11 days after USPIO infusion.
Nine patients were included in the final analysis. Parenchymal USPIO enhancement occurred in 3 of 9 analyzed patients and was mainly evident on T1-weighted spin-echo images. USPIO-dependent signal changes were spatially heterogeneous, reflecting the distinct patterns of hematogenous macrophage infiltration in different lesion types.
Our findings suggest a variable extent and distribution of macrophage infiltration into early ischemic stroke lesions. USPIO-enhanced MRI may help to more specifically target antiinflammatory therapy in patients with stroke.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>17717318</pmid><doi>10.1161/strokeaha.107.481788</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | Journals@Ovid Ovid Autoload; MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Aged Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Brain Ischemia - immunology Brain Ischemia - pathology Contrast Media Dextrans Early Diagnosis Encephalitis - immunology Encephalitis - pathology Female Ferrosoferric Oxide Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Iron Macrophages - pathology Magnetic Resonance Imaging - methods Magnetite Nanoparticles Male Medical sciences Middle Aged Nervous system (semeiology, syndromes) Neurology Oxides Pharmacology. Drug treatments Stroke - immunology Stroke - pathology Vascular diseases and vascular malformations of the nervous system |
| title | Iron oxide particle-enhanced MRI suggests variability of brain inflammation at early stages after ischemic stroke |
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