Use of preoperative serum CA-125 levels for prediction of lymph node metastasis and prognosis in endometrial cancer
Background. The purpose of this study was to evaluate the predictive value of preoperative serum CA-125 levels in the assessment of disease extent and clinical outcome of endometrial cancer. Method. This retrospective study evaluated 92 women with pathologically proven endometrial carcinoma schedule...
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| Veröffentlicht in: | Acta obstetricia et gynecologica Scandinavica 2006-12, Vol.85 (12), p.1501-1505 |
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| container_title | Acta obstetricia et gynecologica Scandinavica |
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| creator | Hoon Chung, Hyun Weon Kim, Jae Park, Noh-Hyun Song, Yong-Sang Kang, Soon-Beom Lee, Hyo-Pyo |
| description | Background. The purpose of this study was to evaluate the predictive value of preoperative serum CA-125 levels in the assessment of disease extent and clinical outcome of endometrial cancer. Method. This retrospective study evaluated 92 women with pathologically proven endometrial carcinoma scheduled for treatment that had preoperative serum CA-125 levels between January 1999 and February 2006. The association of preoperative serum CA-125 with a variety of histopathologic factors was evaluated. Statistical analysis was performed using 2/Fisher's exact test and a logistic regression. Survival was studied with the Kaplan-Meier method and Cox regression models. Results. Elevated serum CA-125 levels were significantly correlated with advanced-stage disease (p |
| doi_str_mv | 10.1080/00016340601022777 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68309583</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68309583</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5082-8e4e9d0ac2401078f1ce5d6c5baecaaf74eef009c7e0aad95503da24f46d29c93</originalsourceid><addsrcrecordid>eNqFkUFv1DAQhSMEokvhB3BBvsAtMHacOBGnZQVbUNVKiMLRmjoT1sWJt3ZS2H-Po43oAQkkS9Zovjf2e5Nlzzm85lDDGwDgVSGhAg5CKKUeZCteAeQguXiYreZ-noDmJHsS402qhJL14-yEK1ElRbPK4lUk5ju2D-T3FHC0d8Qihalnm3XORckc3ZGLrPNhhlprRuuHWeIO_X7HBt8S62nEmI6NDIc2cf774OfKDoyG1qd-sOiYwcFQeJo96tBFerbcp9nVh_dfNmf5-eX242Z9npsSapHXJKlpAY2QyZ-qO26obCtTXiMZxE5Jog6gMYoAsW3KEooWhexk1YrGNMVp9uo4N_3ndqI46t5GQ87hQH6KuqoLaMq6SCA_gib4GAN1eh9sj-GgOeg5af1X0knzYhk-XffU3iuWaBPwcgEwGnRdSN5tvOfqokqmZOLKI_fTOjr8_2W9vtwWIJIuP-psHOnXHx2GH7pShSr1t4ut3n59Jzefzj7ri8S_Xfgh7bLHHaEbdwYD6Rs_hSFt4h92fwN3Wbd2</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68309583</pqid></control><display><type>article</type><title>Use of preoperative serum CA-125 levels for prediction of lymph node metastasis and prognosis in endometrial cancer</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Hoon Chung, Hyun ; Weon Kim, Jae ; Park, Noh-Hyun ; Song, Yong-Sang ; Kang, Soon-Beom ; Lee, Hyo-Pyo</creator><creatorcontrib>Hoon Chung, Hyun ; Weon Kim, Jae ; Park, Noh-Hyun ; Song, Yong-Sang ; Kang, Soon-Beom ; Lee, Hyo-Pyo</creatorcontrib><description>Background. The purpose of this study was to evaluate the predictive value of preoperative serum CA-125 levels in the assessment of disease extent and clinical outcome of endometrial cancer. Method. This retrospective study evaluated 92 women with pathologically proven endometrial carcinoma scheduled for treatment that had preoperative serum CA-125 levels between January 1999 and February 2006. The association of preoperative serum CA-125 with a variety of histopathologic factors was evaluated. Statistical analysis was performed using 2/Fisher's exact test and a logistic regression. Survival was studied with the Kaplan-Meier method and Cox regression models. Results. Elevated serum CA-125 levels were significantly correlated with advanced-stage disease (p<0.001), lymph node metastases (p<0.001), increased depth of myometrial invasion (p=0.001), and positive peritoneal cytology (p=0.026). Multivariate analyses using logistic regression showed that lymph node metastases had the most significant effect on the elevation of preoperative serum CA-125 levels (p=0.004). Patients with a serum CA-125 ≤28.5 U/ml had a significantly better five-year disease-free survival than those with an elevated level in this study: 85.6% versus 60.0% (p=0.004). Conclusions. The preoperative serum CA-125 level appears to be a significant independent predictor of lymph node metastasis and prognosis after surgical intervention. Therefore, preoperative serum CA-125 may be a useful tool, in the clinical setting, for optimal individualized patient management.</description><identifier>ISSN: 0001-6349</identifier><identifier>EISSN: 1600-0412</identifier><identifier>DOI: 10.1080/00016340601022777</identifier><identifier>PMID: 17260229</identifier><identifier>CODEN: AOGSAE</identifier><language>eng</language><publisher>Oxford, UK: Informa UK Ltd</publisher><subject>Biological and medical sciences ; CA-125 ; CA-125 Antigen - blood ; Carcinoma, Endometrioid - blood ; Carcinoma, Endometrioid - secondary ; Carcinoma, Endometrioid - surgery ; Chi-Square Distribution ; Disease-Free Survival ; endometrial cancer ; Endometrial Neoplasms - blood ; Endometrial Neoplasms - pathology ; Endometrial Neoplasms - surgery ; Female ; Female genital diseases ; Gynecology. Andrology. Obstetrics ; Hematologic and hematopoietic diseases ; Humans ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Logistic Models ; lymph node ; Lymph Node Excision ; Lymph Nodes - pathology ; Lymphatic Metastasis - diagnosis ; Lymphatic Metastasis - pathology ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Neoplasm Staging ; Predictive Value of Tests ; Preoperative Care ; Prognosis ; Proportional Hazards Models ; Retrospective Studies ; ROC Curve ; Sensitivity and Specificity ; Tumors</subject><ispartof>Acta obstetricia et gynecologica Scandinavica, 2006-12, Vol.85 (12), p.1501-1505</ispartof><rights>2006 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2006</rights><rights>Acta Obstet Gynecol Scand 2006</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5082-8e4e9d0ac2401078f1ce5d6c5baecaaf74eef009c7e0aad95503da24f46d29c93</citedby><cites>FETCH-LOGICAL-c5082-8e4e9d0ac2401078f1ce5d6c5baecaaf74eef009c7e0aad95503da24f46d29c93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1080%2F00016340601022777$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1080%2F00016340601022777$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18360784$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17260229$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hoon Chung, Hyun</creatorcontrib><creatorcontrib>Weon Kim, Jae</creatorcontrib><creatorcontrib>Park, Noh-Hyun</creatorcontrib><creatorcontrib>Song, Yong-Sang</creatorcontrib><creatorcontrib>Kang, Soon-Beom</creatorcontrib><creatorcontrib>Lee, Hyo-Pyo</creatorcontrib><title>Use of preoperative serum CA-125 levels for prediction of lymph node metastasis and prognosis in endometrial cancer</title><title>Acta obstetricia et gynecologica Scandinavica</title><addtitle>Acta Obstet Gynecol Scand</addtitle><description>Background. The purpose of this study was to evaluate the predictive value of preoperative serum CA-125 levels in the assessment of disease extent and clinical outcome of endometrial cancer. Method. This retrospective study evaluated 92 women with pathologically proven endometrial carcinoma scheduled for treatment that had preoperative serum CA-125 levels between January 1999 and February 2006. The association of preoperative serum CA-125 with a variety of histopathologic factors was evaluated. Statistical analysis was performed using 2/Fisher's exact test and a logistic regression. Survival was studied with the Kaplan-Meier method and Cox regression models. Results. Elevated serum CA-125 levels were significantly correlated with advanced-stage disease (p<0.001), lymph node metastases (p<0.001), increased depth of myometrial invasion (p=0.001), and positive peritoneal cytology (p=0.026). Multivariate analyses using logistic regression showed that lymph node metastases had the most significant effect on the elevation of preoperative serum CA-125 levels (p=0.004). Patients with a serum CA-125 ≤28.5 U/ml had a significantly better five-year disease-free survival than those with an elevated level in this study: 85.6% versus 60.0% (p=0.004). Conclusions. The preoperative serum CA-125 level appears to be a significant independent predictor of lymph node metastasis and prognosis after surgical intervention. Therefore, preoperative serum CA-125 may be a useful tool, in the clinical setting, for optimal individualized patient management.</description><subject>Biological and medical sciences</subject><subject>CA-125</subject><subject>CA-125 Antigen - blood</subject><subject>Carcinoma, Endometrioid - blood</subject><subject>Carcinoma, Endometrioid - secondary</subject><subject>Carcinoma, Endometrioid - surgery</subject><subject>Chi-Square Distribution</subject><subject>Disease-Free Survival</subject><subject>endometrial cancer</subject><subject>Endometrial Neoplasms - blood</subject><subject>Endometrial Neoplasms - pathology</subject><subject>Endometrial Neoplasms - surgery</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Logistic Models</subject><subject>lymph node</subject><subject>Lymph Node Excision</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphatic Metastasis - diagnosis</subject><subject>Lymphatic Metastasis - pathology</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Neoplasm Staging</subject><subject>Predictive Value of Tests</subject><subject>Preoperative Care</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Retrospective Studies</subject><subject>ROC Curve</subject><subject>Sensitivity and Specificity</subject><subject>Tumors</subject><issn>0001-6349</issn><issn>1600-0412</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQhSMEokvhB3BBvsAtMHacOBGnZQVbUNVKiMLRmjoT1sWJt3ZS2H-Po43oAQkkS9Zovjf2e5Nlzzm85lDDGwDgVSGhAg5CKKUeZCteAeQguXiYreZ-noDmJHsS402qhJL14-yEK1ElRbPK4lUk5ju2D-T3FHC0d8Qihalnm3XORckc3ZGLrPNhhlprRuuHWeIO_X7HBt8S62nEmI6NDIc2cf774OfKDoyG1qd-sOiYwcFQeJo96tBFerbcp9nVh_dfNmf5-eX242Z9npsSapHXJKlpAY2QyZ-qO26obCtTXiMZxE5Jog6gMYoAsW3KEooWhexk1YrGNMVp9uo4N_3ndqI46t5GQ87hQH6KuqoLaMq6SCA_gib4GAN1eh9sj-GgOeg5af1X0knzYhk-XffU3iuWaBPwcgEwGnRdSN5tvOfqokqmZOLKI_fTOjr8_2W9vtwWIJIuP-psHOnXHx2GH7pShSr1t4ut3n59Jzefzj7ri8S_Xfgh7bLHHaEbdwYD6Rs_hSFt4h92fwN3Wbd2</recordid><startdate>200612</startdate><enddate>200612</enddate><creator>Hoon Chung, Hyun</creator><creator>Weon Kim, Jae</creator><creator>Park, Noh-Hyun</creator><creator>Song, Yong-Sang</creator><creator>Kang, Soon-Beom</creator><creator>Lee, Hyo-Pyo</creator><general>Informa UK Ltd</general><general>Blackwell Publishing Ltd</general><general>Taylor & Francis</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200612</creationdate><title>Use of preoperative serum CA-125 levels for prediction of lymph node metastasis and prognosis in endometrial cancer</title><author>Hoon Chung, Hyun ; Weon Kim, Jae ; Park, Noh-Hyun ; Song, Yong-Sang ; Kang, Soon-Beom ; Lee, Hyo-Pyo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5082-8e4e9d0ac2401078f1ce5d6c5baecaaf74eef009c7e0aad95503da24f46d29c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Biological and medical sciences</topic><topic>CA-125</topic><topic>CA-125 Antigen - blood</topic><topic>Carcinoma, Endometrioid - blood</topic><topic>Carcinoma, Endometrioid - secondary</topic><topic>Carcinoma, Endometrioid - surgery</topic><topic>Chi-Square Distribution</topic><topic>Disease-Free Survival</topic><topic>endometrial cancer</topic><topic>Endometrial Neoplasms - blood</topic><topic>Endometrial Neoplasms - pathology</topic><topic>Endometrial Neoplasms - surgery</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Logistic Models</topic><topic>lymph node</topic><topic>Lymph Node Excision</topic><topic>Lymph Nodes - pathology</topic><topic>Lymphatic Metastasis - diagnosis</topic><topic>Lymphatic Metastasis - pathology</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Neoplasm Staging</topic><topic>Predictive Value of Tests</topic><topic>Preoperative Care</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Retrospective Studies</topic><topic>ROC Curve</topic><topic>Sensitivity and Specificity</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hoon Chung, Hyun</creatorcontrib><creatorcontrib>Weon Kim, Jae</creatorcontrib><creatorcontrib>Park, Noh-Hyun</creatorcontrib><creatorcontrib>Song, Yong-Sang</creatorcontrib><creatorcontrib>Kang, Soon-Beom</creatorcontrib><creatorcontrib>Lee, Hyo-Pyo</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta obstetricia et gynecologica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hoon Chung, Hyun</au><au>Weon Kim, Jae</au><au>Park, Noh-Hyun</au><au>Song, Yong-Sang</au><au>Kang, Soon-Beom</au><au>Lee, Hyo-Pyo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of preoperative serum CA-125 levels for prediction of lymph node metastasis and prognosis in endometrial cancer</atitle><jtitle>Acta obstetricia et gynecologica Scandinavica</jtitle><addtitle>Acta Obstet Gynecol Scand</addtitle><date>2006-12</date><risdate>2006</risdate><volume>85</volume><issue>12</issue><spage>1501</spage><epage>1505</epage><pages>1501-1505</pages><issn>0001-6349</issn><eissn>1600-0412</eissn><coden>AOGSAE</coden><abstract>Background. The purpose of this study was to evaluate the predictive value of preoperative serum CA-125 levels in the assessment of disease extent and clinical outcome of endometrial cancer. Method. This retrospective study evaluated 92 women with pathologically proven endometrial carcinoma scheduled for treatment that had preoperative serum CA-125 levels between January 1999 and February 2006. The association of preoperative serum CA-125 with a variety of histopathologic factors was evaluated. Statistical analysis was performed using 2/Fisher's exact test and a logistic regression. Survival was studied with the Kaplan-Meier method and Cox regression models. Results. Elevated serum CA-125 levels were significantly correlated with advanced-stage disease (p<0.001), lymph node metastases (p<0.001), increased depth of myometrial invasion (p=0.001), and positive peritoneal cytology (p=0.026). Multivariate analyses using logistic regression showed that lymph node metastases had the most significant effect on the elevation of preoperative serum CA-125 levels (p=0.004). Patients with a serum CA-125 ≤28.5 U/ml had a significantly better five-year disease-free survival than those with an elevated level in this study: 85.6% versus 60.0% (p=0.004). Conclusions. The preoperative serum CA-125 level appears to be a significant independent predictor of lymph node metastasis and prognosis after surgical intervention. Therefore, preoperative serum CA-125 may be a useful tool, in the clinical setting, for optimal individualized patient management.</abstract><cop>Oxford, UK</cop><pub>Informa UK Ltd</pub><pmid>17260229</pmid><doi>10.1080/00016340601022777</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biological and medical sciences CA-125 CA-125 Antigen - blood Carcinoma, Endometrioid - blood Carcinoma, Endometrioid - secondary Carcinoma, Endometrioid - surgery Chi-Square Distribution Disease-Free Survival endometrial cancer Endometrial Neoplasms - blood Endometrial Neoplasms - pathology Endometrial Neoplasms - surgery Female Female genital diseases Gynecology. Andrology. Obstetrics Hematologic and hematopoietic diseases Humans Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Logistic Models lymph node Lymph Node Excision Lymph Nodes - pathology Lymphatic Metastasis - diagnosis Lymphatic Metastasis - pathology Medical sciences Middle Aged Multivariate Analysis Neoplasm Staging Predictive Value of Tests Preoperative Care Prognosis Proportional Hazards Models Retrospective Studies ROC Curve Sensitivity and Specificity Tumors |
| title | Use of preoperative serum CA-125 levels for prediction of lymph node metastasis and prognosis in endometrial cancer |
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