The gastric effects of UFP-112, a new nociceptin/orphanin receptor agonist, in physiological and pathological conditions

Nociceptin/orphanin FQ (N/OFQ), the endogenous NOP receptor ligand, centrally modulates gastric motor and secretory functions and prevents ethanol-induced gastric lesions in rats. A recently synthesized N/OFQ analog, [(pF)Phe 4Aib 7Arg 14Lys 15]N/OFQ-NH 2 (UFP-112), acts as a highly potent and selec...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2007-10, Vol.28 (10), p.1974-1981
Hauptverfasser:	Broccardo, M., Guerrini, R., Morini, G., Polidori, C., Agostini, S., Petrella, C., Improta, G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Fundamental and applied biological sciences. Psychology Gastric emptying Gastric Emptying - drug effects Opioid Peptides - pharmacology Rats Receptors, Opioid - agonists Secretion and ulcers Stomach - drug effects UFP-112 Vertebrates: endocrinology
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