Collective diffusion coefficient of proteins with hydrodynamic, electrostatic, and adhesive interactions
A theory is presented for λ C , the coefficient of the first-order correction in the density of the collective diffusion coefficient, for protein spheres interacting by electrostatic and adhesive forces. An extensive numerical analysis of the Stokesian hydrodynamics of two moving spheres is given so...
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| Veröffentlicht in: | The Journal of chemical physics 2007-09, Vol.127 (11), p.115102-115102-7 |
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| container_end_page | 115102-7 |
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| container_issue | 11 |
| container_start_page | 115102 |
| container_title | The Journal of chemical physics |
| container_volume | 127 |
| creator | Prinsen, Peter Odijk, Theo |
| description | A theory is presented for
λ
C
, the coefficient of the first-order correction in the density of the collective diffusion coefficient, for protein spheres interacting by electrostatic and adhesive forces. An extensive numerical analysis of the Stokesian hydrodynamics of two moving spheres is given so as to gauge the precise impact of lubrication forces. An effective stickiness is introduced and a simple formula for
λ
C
in terms of this variable is put forward. A precise though more elaborate approximation for
λ
C
is also developed. These and numerically exact expressions for
λ
C
are compared with experimental data on lysozyme at
p
H
4.5 and a range of ionic strengths between
0.05
M
and
2
M
. |
| doi_str_mv | 10.1063/1.2771160 |
| format | Article |
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λ
C
, the coefficient of the first-order correction in the density of the collective diffusion coefficient, for protein spheres interacting by electrostatic and adhesive forces. An extensive numerical analysis of the Stokesian hydrodynamics of two moving spheres is given so as to gauge the precise impact of lubrication forces. An effective stickiness is introduced and a simple formula for
λ
C
in terms of this variable is put forward. A precise though more elaborate approximation for
λ
C
is also developed. These and numerically exact expressions for
λ
C
are compared with experimental data on lysozyme at
p
H
4.5 and a range of ionic strengths between
0.05
M
and
2
M
.</description><identifier>ISSN: 0021-9606</identifier><identifier>EISSN: 1089-7690</identifier><identifier>DOI: 10.1063/1.2771160</identifier><identifier>PMID: 17887883</identifier><identifier>CODEN: JCPSA6</identifier><language>eng</language><publisher>United States: American Institute of Physics</publisher><subject>Algorithms ; Biophysics - methods ; Cell Adhesion ; Chemistry, Physical - methods ; Diffusion ; Hydrogen-Ion Concentration ; Ions ; Models, Statistical ; Models, Theoretical ; Protein Binding ; Proteins - chemistry ; Static Electricity ; Water - chemistry</subject><ispartof>The Journal of chemical physics, 2007-09, Vol.127 (11), p.115102-115102-7</ispartof><rights>2007 American Institute of Physics</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c373t-c395a2e45ec28b1023e4f6ec22b45c6fc27e063f2fa61a6a9fefde0f6580ff9a3</citedby><cites>FETCH-LOGICAL-c373t-c395a2e45ec28b1023e4f6ec22b45c6fc27e063f2fa61a6a9fefde0f6580ff9a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,790,1553,4498,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17887883$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Prinsen, Peter</creatorcontrib><creatorcontrib>Odijk, Theo</creatorcontrib><title>Collective diffusion coefficient of proteins with hydrodynamic, electrostatic, and adhesive interactions</title><title>The Journal of chemical physics</title><addtitle>J Chem Phys</addtitle><description>A theory is presented for
λ
C
, the coefficient of the first-order correction in the density of the collective diffusion coefficient, for protein spheres interacting by electrostatic and adhesive forces. An extensive numerical analysis of the Stokesian hydrodynamics of two moving spheres is given so as to gauge the precise impact of lubrication forces. An effective stickiness is introduced and a simple formula for
λ
C
in terms of this variable is put forward. A precise though more elaborate approximation for
λ
C
is also developed. These and numerically exact expressions for
λ
C
are compared with experimental data on lysozyme at
p
H
4.5 and a range of ionic strengths between
0.05
M
and
2
M
.</description><subject>Algorithms</subject><subject>Biophysics - methods</subject><subject>Cell Adhesion</subject><subject>Chemistry, Physical - methods</subject><subject>Diffusion</subject><subject>Hydrogen-Ion Concentration</subject><subject>Ions</subject><subject>Models, Statistical</subject><subject>Models, Theoretical</subject><subject>Protein Binding</subject><subject>Proteins - chemistry</subject><subject>Static Electricity</subject><subject>Water - chemistry</subject><issn>0021-9606</issn><issn>1089-7690</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1LxDAQhoMo7rp68A9IT4Jg13y0aXsRZPELFrzoOWTTCY20ydqkyv57U7a4JyFMGHjmZeZB6JLgJcGc3ZElLQpCOD5Cc4LLKi14hY_RHGNK0opjPkNn3n9ijElBs1M0I0VZxsfmqFm5tgUVzDcktdF68MbZRDnQ2igDNiROJ9veBTDWJz8mNEmzq3tX76zsjLpNYJzunQ8yjK20dSLrBvwYaGyAXsZwZ_05OtGy9XAx_Qv08fT4vnpJ12_Pr6uHdapYwUKsVS4pZDkoWm4IpgwyzWNDN1muuFa0gHiyplpyIrmsNOgasOZ5ibWuJFug631uXPprAB9EZ7yCtpUW3OAFLxkuy4xE8GYPqri970GLbW862e8EwWLUKoiYtEb2agodNh3UB3LyGIH7PeCVGU04-3_awbj4M85-AZspipg</recordid><startdate>20070921</startdate><enddate>20070921</enddate><creator>Prinsen, Peter</creator><creator>Odijk, Theo</creator><general>American Institute of Physics</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070921</creationdate><title>Collective diffusion coefficient of proteins with hydrodynamic, electrostatic, and adhesive interactions</title><author>Prinsen, Peter ; Odijk, Theo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c373t-c395a2e45ec28b1023e4f6ec22b45c6fc27e063f2fa61a6a9fefde0f6580ff9a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Algorithms</topic><topic>Biophysics - methods</topic><topic>Cell Adhesion</topic><topic>Chemistry, Physical - methods</topic><topic>Diffusion</topic><topic>Hydrogen-Ion Concentration</topic><topic>Ions</topic><topic>Models, Statistical</topic><topic>Models, Theoretical</topic><topic>Protein Binding</topic><topic>Proteins - chemistry</topic><topic>Static Electricity</topic><topic>Water - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Prinsen, Peter</creatorcontrib><creatorcontrib>Odijk, Theo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of chemical physics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Prinsen, Peter</au><au>Odijk, Theo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Collective diffusion coefficient of proteins with hydrodynamic, electrostatic, and adhesive interactions</atitle><jtitle>The Journal of chemical physics</jtitle><addtitle>J Chem Phys</addtitle><date>2007-09-21</date><risdate>2007</risdate><volume>127</volume><issue>11</issue><spage>115102</spage><epage>115102-7</epage><pages>115102-115102-7</pages><issn>0021-9606</issn><eissn>1089-7690</eissn><coden>JCPSA6</coden><abstract>A theory is presented for
λ
C
, the coefficient of the first-order correction in the density of the collective diffusion coefficient, for protein spheres interacting by electrostatic and adhesive forces. An extensive numerical analysis of the Stokesian hydrodynamics of two moving spheres is given so as to gauge the precise impact of lubrication forces. An effective stickiness is introduced and a simple formula for
λ
C
in terms of this variable is put forward. A precise though more elaborate approximation for
λ
C
is also developed. These and numerically exact expressions for
λ
C
are compared with experimental data on lysozyme at
p
H
4.5 and a range of ionic strengths between
0.05
M
and
2
M
.</abstract><cop>United States</cop><pub>American Institute of Physics</pub><pmid>17887883</pmid><doi>10.1063/1.2771160</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-9606 |
| ispartof | The Journal of chemical physics, 2007-09, Vol.127 (11), p.115102-115102-7 |
| issn | 0021-9606 1089-7690 |
| language | eng |
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| source | MEDLINE; AIP Journals Complete; AIP Digital Archive |
| subjects | Algorithms Biophysics - methods Cell Adhesion Chemistry, Physical - methods Diffusion Hydrogen-Ion Concentration Ions Models, Statistical Models, Theoretical Protein Binding Proteins - chemistry Static Electricity Water - chemistry |
| title | Collective diffusion coefficient of proteins with hydrodynamic, electrostatic, and adhesive interactions |
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