Multiple roles of M-CSF in human osteoclastogenesis

Although the critical role of M‐CSF in osteoclastogenesis is well documented, there has been no detailed analysis of how it regulates human osteoclast formation and function in vitro. We used a human osteoclastogenesis model employing CFU‐GM osteoclast precursors cultured for 14 days on dentine with...

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Veröffentlicht in:	Journal of cellular biochemistry 2007-10, Vol.102 (3), p.759-768
Hauptverfasser:	Hodge, Jason M., Kirkland, Mark A., Nicholson, Geoffrey C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bone Resorption Cell Differentiation cell fusion Cell Proliferation Cell Survival Cells, Cultured CFU-GM Cytoplasm - metabolism differentiation Fetal Blood - cytology Granulocyte-Macrophage Colony-Stimulating Factor - metabolism Humans M-CSF Macrophage Colony-Stimulating Factor - metabolism Macrophage Colony-Stimulating Factor - physiology Membrane Glycoproteins - metabolism Models, Biological osteoclastogenesis Osteoclasts - cytology Osteoclasts - metabolism proliferation Signal Transduction Time Factors
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