Seroprevalence of Herpes Simplex Virus Type 1 in Children in the United States
Objectives To describe HSV-1 seroprevalence in children in the United States and to examine factors associated with herpes simplex virus type 1 (HSV-1) infection in children. Study design Sera samples available from 2989 children age 6 to 13 years who participated in the National Health and Nutritio...
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| Veröffentlicht in: | The Journal of pediatrics 2007-10, Vol.151 (4), p.374-377 |
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| container_title | The Journal of pediatrics |
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| creator | Xu, Fujie, MD, PhD Lee, Francis K., PhD Morrow, Rhoda A., PhD Sternberg, Maya R., PhD Luther, Kristina E., MPH Dubin, Gary, MD Markowitz, Lauri E., MD |
| description | Objectives To describe HSV-1 seroprevalence in children in the United States and to examine factors associated with herpes simplex virus type 1 (HSV-1) infection in children. Study design Sera samples available from 2989 children age 6 to 13 years who participated in the National Health and Nutrition Examination Surveys (NHANES) 1999-2002 were tested for HSV-1 antibodies using a type-specific immunodot assay. HSV-1 seroprevalence in children age 12 to 13 years was compared with that reported in an earlier survey (NHANES 1988-1994). Results Overall, HSV-1 seroprevalence in children age 6 to 13 years was 31.1% (95% confidence interval [CI], 28.6% to 33.9%). Seroprevalence increased with age, from 26.3% in 6- to 7-year-olds to 36.1% in 12-to 13-year-olds, and varied by race/ethnicity, birthplace, and poverty level. Among US-born children age 12 to 13 years, the point estimate of HSV-1 seroprevalence was lower in NHANES 1999-2002 than in NHANES 1988-1994 (34.3% vs 38.1%), but the differences were not statistically significant. Conclusions HSV-1 is a common infection in US children, with more than 25% infected by age 7. Race/ethnicity, birthplace, and poverty level are predictors for HSV-1 infection in children. |
| doi_str_mv | 10.1016/j.jpeds.2007.04.065 |
| format | Article |
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Study design Sera samples available from 2989 children age 6 to 13 years who participated in the National Health and Nutrition Examination Surveys (NHANES) 1999-2002 were tested for HSV-1 antibodies using a type-specific immunodot assay. HSV-1 seroprevalence in children age 12 to 13 years was compared with that reported in an earlier survey (NHANES 1988-1994). Results Overall, HSV-1 seroprevalence in children age 6 to 13 years was 31.1% (95% confidence interval [CI], 28.6% to 33.9%). Seroprevalence increased with age, from 26.3% in 6- to 7-year-olds to 36.1% in 12-to 13-year-olds, and varied by race/ethnicity, birthplace, and poverty level. Among US-born children age 12 to 13 years, the point estimate of HSV-1 seroprevalence was lower in NHANES 1999-2002 than in NHANES 1988-1994 (34.3% vs 38.1%), but the differences were not statistically significant. Conclusions HSV-1 is a common infection in US children, with more than 25% infected by age 7. Race/ethnicity, birthplace, and poverty level are predictors for HSV-1 infection in children.</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/j.jpeds.2007.04.065</identifier><identifier>PMID: 17889072</identifier><identifier>CODEN: JOPDAB</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adolescent ; African Americans - statistics & numerical data ; Age Distribution ; Biological and medical sciences ; Child ; Cross-Sectional Studies ; Epidemiology ; European Continental Ancestry Group - statistics & numerical data ; General aspects ; Herpes Simplex - epidemiology ; Herpes Simplex - ethnology ; Herpesvirus 1, Human ; Humans ; Medical sciences ; Mexican Americans - statistics & numerical data ; Pediatrics ; Poverty ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Seroepidemiologic Studies ; Sex Distribution ; United States - epidemiology</subject><ispartof>The Journal of pediatrics, 2007-10, Vol.151 (4), p.374-377</ispartof><rights>Mosby, Inc.</rights><rights>2007 Mosby, Inc.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-3a7881cafb3fad8efc25fee3bdfbb307d56ac47980fac341b09a439a6ec5a0903</citedby><cites>FETCH-LOGICAL-c442t-3a7881cafb3fad8efc25fee3bdfbb307d56ac47980fac341b09a439a6ec5a0903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jpeds.2007.04.065$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19943036$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17889072$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Fujie, MD, PhD</creatorcontrib><creatorcontrib>Lee, Francis K., PhD</creatorcontrib><creatorcontrib>Morrow, Rhoda A., PhD</creatorcontrib><creatorcontrib>Sternberg, Maya R., PhD</creatorcontrib><creatorcontrib>Luther, Kristina E., MPH</creatorcontrib><creatorcontrib>Dubin, Gary, MD</creatorcontrib><creatorcontrib>Markowitz, Lauri E., MD</creatorcontrib><title>Seroprevalence of Herpes Simplex Virus Type 1 in Children in the United States</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>Objectives To describe HSV-1 seroprevalence in children in the United States and to examine factors associated with herpes simplex virus type 1 (HSV-1) infection in children. Study design Sera samples available from 2989 children age 6 to 13 years who participated in the National Health and Nutrition Examination Surveys (NHANES) 1999-2002 were tested for HSV-1 antibodies using a type-specific immunodot assay. HSV-1 seroprevalence in children age 12 to 13 years was compared with that reported in an earlier survey (NHANES 1988-1994). Results Overall, HSV-1 seroprevalence in children age 6 to 13 years was 31.1% (95% confidence interval [CI], 28.6% to 33.9%). Seroprevalence increased with age, from 26.3% in 6- to 7-year-olds to 36.1% in 12-to 13-year-olds, and varied by race/ethnicity, birthplace, and poverty level. Among US-born children age 12 to 13 years, the point estimate of HSV-1 seroprevalence was lower in NHANES 1999-2002 than in NHANES 1988-1994 (34.3% vs 38.1%), but the differences were not statistically significant. Conclusions HSV-1 is a common infection in US children, with more than 25% infected by age 7. Race/ethnicity, birthplace, and poverty level are predictors for HSV-1 infection in children.</description><subject>Adolescent</subject><subject>African Americans - statistics & numerical data</subject><subject>Age Distribution</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Cross-Sectional Studies</subject><subject>Epidemiology</subject><subject>European Continental Ancestry Group - statistics & numerical data</subject><subject>General aspects</subject><subject>Herpes Simplex - epidemiology</subject><subject>Herpes Simplex - ethnology</subject><subject>Herpesvirus 1, Human</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Mexican Americans - statistics & numerical data</subject><subject>Pediatrics</subject><subject>Poverty</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Seroepidemiologic Studies</subject><subject>Sex Distribution</subject><subject>United States - epidemiology</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi1ERZfCL0BCvsAt6Th2PnwAqVoBRaraw7ZcLcceqw7ZJNhJxf57HHalSlw4zRyed2b0DCHvGOQMWHXZ5d2ENuYFQJ2DyKEqX5ANA1lnVcP5S7IBKIqMi7o6J69j7ABACoBX5JzVTSOhLjbkdodhnAI-6R4Hg3R09BrDhJHu_H7q8Tf94cMS6f1hQsqoH-j20fc24LD28yPSh8HPaOlu1jPGN-TM6T7i21O9IA9fv9xvr7Obu2_ft1c3mRGimDOu0wHMaNdyp22DzhSlQ-StdW3LobZlpY2oZQNOGy5YC1ILLnWFptQggV-Qj8e5Uxh_LRhntffRYN_rAcclqiQAmqIUCeRH0IQxxoBOTcHvdTgoBmrVqDr1V6NaNSoQKmlMqfen8Uu7R_ucOXlLwIcToKPRvQt6MD4-c1IKDrxK3Kcjh0nGk8egovGraOsDmlnZ0f_nkM__5E3vB59W_sQDxm5cwpA8K6ZioUDt1o-vD4caIJlu-B_gQKaF</recordid><startdate>20071001</startdate><enddate>20071001</enddate><creator>Xu, Fujie, MD, PhD</creator><creator>Lee, Francis K., PhD</creator><creator>Morrow, Rhoda A., PhD</creator><creator>Sternberg, Maya R., PhD</creator><creator>Luther, Kristina E., MPH</creator><creator>Dubin, Gary, MD</creator><creator>Markowitz, Lauri E., MD</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20071001</creationdate><title>Seroprevalence of Herpes Simplex Virus Type 1 in Children in the United States</title><author>Xu, Fujie, MD, PhD ; Lee, Francis K., PhD ; Morrow, Rhoda A., PhD ; Sternberg, Maya R., PhD ; Luther, Kristina E., MPH ; Dubin, Gary, MD ; Markowitz, Lauri E., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-3a7881cafb3fad8efc25fee3bdfbb307d56ac47980fac341b09a439a6ec5a0903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>African Americans - statistics & numerical data</topic><topic>Age Distribution</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Cross-Sectional Studies</topic><topic>Epidemiology</topic><topic>European Continental Ancestry Group - statistics & numerical data</topic><topic>General aspects</topic><topic>Herpes Simplex - epidemiology</topic><topic>Herpes Simplex - ethnology</topic><topic>Herpesvirus 1, Human</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Mexican Americans - statistics & numerical data</topic><topic>Pediatrics</topic><topic>Poverty</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Seroepidemiologic Studies</topic><topic>Sex Distribution</topic><topic>United States - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Fujie, MD, PhD</creatorcontrib><creatorcontrib>Lee, Francis K., PhD</creatorcontrib><creatorcontrib>Morrow, Rhoda A., PhD</creatorcontrib><creatorcontrib>Sternberg, Maya R., PhD</creatorcontrib><creatorcontrib>Luther, Kristina E., MPH</creatorcontrib><creatorcontrib>Dubin, Gary, MD</creatorcontrib><creatorcontrib>Markowitz, Lauri E., MD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Fujie, MD, PhD</au><au>Lee, Francis K., PhD</au><au>Morrow, Rhoda A., PhD</au><au>Sternberg, Maya R., PhD</au><au>Luther, Kristina E., MPH</au><au>Dubin, Gary, MD</au><au>Markowitz, Lauri E., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Seroprevalence of Herpes Simplex Virus Type 1 in Children in the United States</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>2007-10-01</date><risdate>2007</risdate><volume>151</volume><issue>4</issue><spage>374</spage><epage>377</epage><pages>374-377</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><coden>JOPDAB</coden><abstract>Objectives To describe HSV-1 seroprevalence in children in the United States and to examine factors associated with herpes simplex virus type 1 (HSV-1) infection in children. Study design Sera samples available from 2989 children age 6 to 13 years who participated in the National Health and Nutrition Examination Surveys (NHANES) 1999-2002 were tested for HSV-1 antibodies using a type-specific immunodot assay. HSV-1 seroprevalence in children age 12 to 13 years was compared with that reported in an earlier survey (NHANES 1988-1994). Results Overall, HSV-1 seroprevalence in children age 6 to 13 years was 31.1% (95% confidence interval [CI], 28.6% to 33.9%). Seroprevalence increased with age, from 26.3% in 6- to 7-year-olds to 36.1% in 12-to 13-year-olds, and varied by race/ethnicity, birthplace, and poverty level. Among US-born children age 12 to 13 years, the point estimate of HSV-1 seroprevalence was lower in NHANES 1999-2002 than in NHANES 1988-1994 (34.3% vs 38.1%), but the differences were not statistically significant. Conclusions HSV-1 is a common infection in US children, with more than 25% infected by age 7. Race/ethnicity, birthplace, and poverty level are predictors for HSV-1 infection in children.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>17889072</pmid><doi>10.1016/j.jpeds.2007.04.065</doi><tpages>4</tpages></addata></record> |
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| subjects | Adolescent African Americans - statistics & numerical data Age Distribution Biological and medical sciences Child Cross-Sectional Studies Epidemiology European Continental Ancestry Group - statistics & numerical data General aspects Herpes Simplex - epidemiology Herpes Simplex - ethnology Herpesvirus 1, Human Humans Medical sciences Mexican Americans - statistics & numerical data Pediatrics Poverty Public health. Hygiene Public health. Hygiene-occupational medicine Seroepidemiologic Studies Sex Distribution United States - epidemiology |
| title | Seroprevalence of Herpes Simplex Virus Type 1 in Children in the United States |
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