Perioperative administration of probiotics: effects on immune response, anastomotic resistance and colonic mucosal trophism
To investigate the effects of perioperative administration of diet containing probiotics on the immune response, anastomotic resistance, and colonic mucosal trophism in rats underwent left-sided colonic anastomosis. Sixty adults Wistar rats were randomized to two groups (A and B) with 30 animals eac...
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| Veröffentlicht in: | Acta cirúrgica brasileira 2006, Vol.21 Suppl 4 (suppl 4), p.80-83 |
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| container_title | Acta cirúrgica brasileira |
| container_volume | 21 Suppl 4 |
| creator | Aguilar-Nascimento, José Eduardo Prado, Sávio Zaffani, Geazi Salomão, Alberto Bicudo Neves, José de Souza Dock-Nascimento, Diana Borges Mello, Paulo Roberto Bezerra de Okay, Thelma Suely |
| description | To investigate the effects of perioperative administration of diet containing probiotics on the immune response, anastomotic resistance, and colonic mucosal trophism in rats underwent left-sided colonic anastomosis.
Sixty adults Wistar rats were randomized to two groups (A and B) with 30 animals each to receive or not a diet supplemented with probiotics (Streptococcus thermophilus e Lactobacillus helveticus) during pre- and postoperative period. They underwent laparotomy followed by left colon section and immediate anastomosis. Groups of 15 animals were killed either on the 4th (groups A1 and B1) or 7th PO (groups A2 and B2) days. The outcome variables were serum proteins, albumin, globulins and IgA, length and weight of the colon, mucosal weight, DNA content and anastomotic bursting pressure.
Colonic weight was greater in probiotic group compared to controls (1.69+/-0.34 g vs 1.48+/-0.26 g; p |
| doi_str_mv | 10.1590/S0102-86502006001000017 |
| format | Article |
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Sixty adults Wistar rats were randomized to two groups (A and B) with 30 animals each to receive or not a diet supplemented with probiotics (Streptococcus thermophilus e Lactobacillus helveticus) during pre- and postoperative period. They underwent laparotomy followed by left colon section and immediate anastomosis. Groups of 15 animals were killed either on the 4th (groups A1 and B1) or 7th PO (groups A2 and B2) days. The outcome variables were serum proteins, albumin, globulins and IgA, length and weight of the colon, mucosal weight, DNA content and anastomotic bursting pressure.
Colonic weight was greater in probiotic group compared to controls (1.69+/-0.34 g vs 1.48+/-0.26 g; p<0.05). Total serum proteins and globulin were higher in probiotic animals (proteins = 7.05+/-0.97 g/dl vs 6.57+/-0.66 g/dl e globulins = 5.1+/-0.62 g/dl vs 4.68+/-1.1 g/dl; p<0.05). Serum IgA increased from basal to post-operative days only in the probiotic group (p<0.01).
Perioperative probiotics enhanced the immune response and colonic weight. Probiotics failed to increase anastomotic resistance.</description><identifier>ISSN: 0102-8650</identifier><identifier>EISSN: 0102-8650</identifier><identifier>DOI: 10.1590/S0102-86502006001000017</identifier><identifier>PMID: 17293972</identifier><language>eng</language><publisher>Brazil</publisher><subject>Anastomosis, Surgical ; Animals ; Colon - surgery ; Immunity, Mucosal ; Intestinal Mucosa - immunology ; Male ; Perioperative Care ; Postoperative Period ; Probiotics - administration & dosage ; Random Allocation ; Rats ; Rats, Wistar ; Tensile Strength ; Wound Healing - immunology</subject><ispartof>Acta cirúrgica brasileira, 2006, Vol.21 Suppl 4 (suppl 4), p.80-83</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3147-8811b7b419ae4b16d7f45c5f48a865e8172ed22b258350d11794de82879d64053</citedby><cites>FETCH-LOGICAL-c3147-8811b7b419ae4b16d7f45c5f48a865e8172ed22b258350d11794de82879d64053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,4014,27914,27915,27916</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17293972$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aguilar-Nascimento, José Eduardo</creatorcontrib><creatorcontrib>Prado, Sávio</creatorcontrib><creatorcontrib>Zaffani, Geazi</creatorcontrib><creatorcontrib>Salomão, Alberto Bicudo</creatorcontrib><creatorcontrib>Neves, José de Souza</creatorcontrib><creatorcontrib>Dock-Nascimento, Diana Borges</creatorcontrib><creatorcontrib>Mello, Paulo Roberto Bezerra de</creatorcontrib><creatorcontrib>Okay, Thelma Suely</creatorcontrib><title>Perioperative administration of probiotics: effects on immune response, anastomotic resistance and colonic mucosal trophism</title><title>Acta cirúrgica brasileira</title><addtitle>Acta Cir Bras</addtitle><description>To investigate the effects of perioperative administration of diet containing probiotics on the immune response, anastomotic resistance, and colonic mucosal trophism in rats underwent left-sided colonic anastomosis.
Sixty adults Wistar rats were randomized to two groups (A and B) with 30 animals each to receive or not a diet supplemented with probiotics (Streptococcus thermophilus e Lactobacillus helveticus) during pre- and postoperative period. They underwent laparotomy followed by left colon section and immediate anastomosis. Groups of 15 animals were killed either on the 4th (groups A1 and B1) or 7th PO (groups A2 and B2) days. The outcome variables were serum proteins, albumin, globulins and IgA, length and weight of the colon, mucosal weight, DNA content and anastomotic bursting pressure.
Colonic weight was greater in probiotic group compared to controls (1.69+/-0.34 g vs 1.48+/-0.26 g; p<0.05). Total serum proteins and globulin were higher in probiotic animals (proteins = 7.05+/-0.97 g/dl vs 6.57+/-0.66 g/dl e globulins = 5.1+/-0.62 g/dl vs 4.68+/-1.1 g/dl; p<0.05). Serum IgA increased from basal to post-operative days only in the probiotic group (p<0.01).
Perioperative probiotics enhanced the immune response and colonic weight. Probiotics failed to increase anastomotic resistance.</description><subject>Anastomosis, Surgical</subject><subject>Animals</subject><subject>Colon - surgery</subject><subject>Immunity, Mucosal</subject><subject>Intestinal Mucosa - immunology</subject><subject>Male</subject><subject>Perioperative Care</subject><subject>Postoperative Period</subject><subject>Probiotics - administration & dosage</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Tensile Strength</subject><subject>Wound Healing - immunology</subject><issn>0102-8650</issn><issn>0102-8650</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplUE1LxDAQDaK46-pf0Jw8uZqkaZN6k8UvWFBQzyVNpxhpkpq0gvjnTXVRwbnM15s3vIfQESWnNC_J2QOhhC1lkRNGSEFSl4KKLTT_WWz_qWdoL8aXhOAFzXbRjApWZqVgc_RxD8H4HoIazBtg1VjjTBym1jvsW9wHXxs_GB3PMbQt6CHitDHWjg5wgNh7F-EEK6fi4O2EnKaJQzmdCF2Dte-8S2M7ah9Vh4fg-2cT7T7aaVUX4WCTF-jp6vJxdbNc313fri7WS51RLpZSUlqLmtNSAa9p0YiW5zpvuVRJG8gkBhrGapbLLCcNpaLkDUgmRdkUnOTZAh1_8yYtryPEobImaug65cCPsSpkRkRZlAkovoE6-BgDtFUfjFXhvaKkmnyvvnyv_vmeLg83L8baQvN7tzE6-wQhuH_V</recordid><startdate>2006</startdate><enddate>2006</enddate><creator>Aguilar-Nascimento, José Eduardo</creator><creator>Prado, Sávio</creator><creator>Zaffani, Geazi</creator><creator>Salomão, Alberto Bicudo</creator><creator>Neves, José de Souza</creator><creator>Dock-Nascimento, Diana Borges</creator><creator>Mello, Paulo Roberto Bezerra de</creator><creator>Okay, Thelma Suely</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2006</creationdate><title>Perioperative administration of probiotics: effects on immune response, anastomotic resistance and colonic mucosal trophism</title><author>Aguilar-Nascimento, José Eduardo ; Prado, Sávio ; Zaffani, Geazi ; Salomão, Alberto Bicudo ; Neves, José de Souza ; Dock-Nascimento, Diana Borges ; Mello, Paulo Roberto Bezerra de ; Okay, Thelma Suely</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3147-8811b7b419ae4b16d7f45c5f48a865e8172ed22b258350d11794de82879d64053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Anastomosis, Surgical</topic><topic>Animals</topic><topic>Colon - surgery</topic><topic>Immunity, Mucosal</topic><topic>Intestinal Mucosa - immunology</topic><topic>Male</topic><topic>Perioperative Care</topic><topic>Postoperative Period</topic><topic>Probiotics - administration & dosage</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Tensile Strength</topic><topic>Wound Healing - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aguilar-Nascimento, José Eduardo</creatorcontrib><creatorcontrib>Prado, Sávio</creatorcontrib><creatorcontrib>Zaffani, Geazi</creatorcontrib><creatorcontrib>Salomão, Alberto Bicudo</creatorcontrib><creatorcontrib>Neves, José de Souza</creatorcontrib><creatorcontrib>Dock-Nascimento, Diana Borges</creatorcontrib><creatorcontrib>Mello, Paulo Roberto Bezerra de</creatorcontrib><creatorcontrib>Okay, Thelma Suely</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta cirúrgica brasileira</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aguilar-Nascimento, José Eduardo</au><au>Prado, Sávio</au><au>Zaffani, Geazi</au><au>Salomão, Alberto Bicudo</au><au>Neves, José de Souza</au><au>Dock-Nascimento, Diana Borges</au><au>Mello, Paulo Roberto Bezerra de</au><au>Okay, Thelma Suely</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Perioperative administration of probiotics: effects on immune response, anastomotic resistance and colonic mucosal trophism</atitle><jtitle>Acta cirúrgica brasileira</jtitle><addtitle>Acta Cir Bras</addtitle><date>2006</date><risdate>2006</risdate><volume>21 Suppl 4</volume><issue>suppl 4</issue><spage>80</spage><epage>83</epage><pages>80-83</pages><issn>0102-8650</issn><eissn>0102-8650</eissn><abstract>To investigate the effects of perioperative administration of diet containing probiotics on the immune response, anastomotic resistance, and colonic mucosal trophism in rats underwent left-sided colonic anastomosis.
Sixty adults Wistar rats were randomized to two groups (A and B) with 30 animals each to receive or not a diet supplemented with probiotics (Streptococcus thermophilus e Lactobacillus helveticus) during pre- and postoperative period. They underwent laparotomy followed by left colon section and immediate anastomosis. Groups of 15 animals were killed either on the 4th (groups A1 and B1) or 7th PO (groups A2 and B2) days. The outcome variables were serum proteins, albumin, globulins and IgA, length and weight of the colon, mucosal weight, DNA content and anastomotic bursting pressure.
Colonic weight was greater in probiotic group compared to controls (1.69+/-0.34 g vs 1.48+/-0.26 g; p<0.05). Total serum proteins and globulin were higher in probiotic animals (proteins = 7.05+/-0.97 g/dl vs 6.57+/-0.66 g/dl e globulins = 5.1+/-0.62 g/dl vs 4.68+/-1.1 g/dl; p<0.05). Serum IgA increased from basal to post-operative days only in the probiotic group (p<0.01).
Perioperative probiotics enhanced the immune response and colonic weight. Probiotics failed to increase anastomotic resistance.</abstract><cop>Brazil</cop><pmid>17293972</pmid><doi>10.1590/S0102-86502006001000017</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Anastomosis, Surgical Animals Colon - surgery Immunity, Mucosal Intestinal Mucosa - immunology Male Perioperative Care Postoperative Period Probiotics - administration & dosage Random Allocation Rats Rats, Wistar Tensile Strength Wound Healing - immunology |
| title | Perioperative administration of probiotics: effects on immune response, anastomotic resistance and colonic mucosal trophism |
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