Nose-to-brain delivery of tacrine

ABSTRACT In the treatment of Alzheimer's disease tacrine, a cholinesterase inhibitor, is not the drug of choice due to its low oral bioavailability, extensive hepatic first‐pass effect, rapid clearance from the systemic circulation, pronounced hepatotoxicity, and the availability of drugs bette...

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Veröffentlicht in:	Journal of pharmacy and pharmacology 2007-09, Vol.59 (9), p.1199-1205
Hauptverfasser:	Jogani, Viral V., Shah, Pranav J., Misra, Ambikanandan R., Mishra, Pushpa, Mishra, Anil Kumar
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Alzheimer Disease - drug therapy Animals Biological Availability Biological Transport Blood-Brain Barrier Brain - metabolism Cholinesterase Inhibitors - administration & dosage Cholinesterase Inhibitors - pharmacokinetics Drug Delivery Systems Drug Stability Injections, Intravenous Mice Mice, Inbred BALB C Propylene Glycol - chemistry Rabbits Radionuclide Imaging Random Allocation Tacrine - administration & dosage Tacrine - pharmacokinetics Technetium Time Factors Tissue Distribution
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