Islet cell, thyroid, adrenal and celiac disease related autoantibodies in patients with Type 1 diabetes from Sri Lanka
The prevalence of islet cell, thyroid, adrenal and celiac disease related autoantibodies in patients with Type 1 diabetes mellitus (Type 1 DM) from Sri Lanka is described. Autoantibodies to glutamic acid decarboxylase 65 (GAD65Ab), protein tyrosine phosphatase IA-2 (IA-2Ab), insulin (IAAb), thyroglo...
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| Veröffentlicht in: | Journal of endocrinological investigation 2006-12, Vol.29 (11), p.968-974 |
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| creator | Premawardhana, L D K E Wijeyaratne, C N Chen, S Wijesuriya, M Illangasekera, U Brooking, H Amoroso, M Jeffreys, J Bolton, J Lazarus, J H Furmaniak, J Rees Smith, B |
| description | The prevalence of islet cell, thyroid, adrenal and celiac disease related autoantibodies in patients with Type 1 diabetes mellitus (Type 1 DM) from Sri Lanka is described.
Autoantibodies to glutamic acid decarboxylase 65 (GAD65Ab), protein tyrosine phosphatase IA-2 (IA-2Ab), insulin (IAAb), thyroglobulin (TgAb), thyroid peroxidase (TPOAb), TSH receptor (TRAb), 21-hydroxylase (21-OHAb) and tissue transglutaminase (tTGAb) were measured in 122 Type 1 DM patients who had low C-peptide activity or were >20 yr old at the time of diagnosis and in 100 non-diabetic blood donors.
GAD65Ab and/or IA-2Ab were present in 74/122 (60.7%) Type 1 DM subjects with a significantly higher prevalence compared to non-diabetic controls (no. 100) (GAD65Ab-59 vs 4%; IA-2Ab-14 vs 0%; respectively) (p or =5 yr (19 vs 4%) (p |
| doi_str_mv | 10.1007/BF03349209 |
| format | Article |
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Autoantibodies to glutamic acid decarboxylase 65 (GAD65Ab), protein tyrosine phosphatase IA-2 (IA-2Ab), insulin (IAAb), thyroglobulin (TgAb), thyroid peroxidase (TPOAb), TSH receptor (TRAb), 21-hydroxylase (21-OHAb) and tissue transglutaminase (tTGAb) were measured in 122 Type 1 DM patients who had low C-peptide activity or were >20 yr old at the time of diagnosis and in 100 non-diabetic blood donors.
GAD65Ab and/or IA-2Ab were present in 74/122 (60.7%) Type 1 DM subjects with a significantly higher prevalence compared to non-diabetic controls (no. 100) (GAD65Ab-59 vs 4%; IA-2Ab-14 vs 0%; respectively) (p<0.001). The median (inter-quartile range) Type 1 DM duration in antibody positive subjects was 3.3 (0.99-6.9) vs 4.9 (1.7-7.5) yr in antibody negative subjects (p=0.23). IA-2Ab prevalence decreased with disease duration > or =5 yr (19 vs 4%) (p<0.001). There was no difference in the prevalence of TgAb (25 vs 33%)(p=0.21) and TPOAb (22 vs 18%) (p=0.48) in Type 1 DM and non-diabetic subjects. Also, there was no difference in TgAb and TPOAb prevalence in antibody positive Type 1 DM (34.7%) compared to antibody negative Type 1 DM (24.4%) subjects (p=0.24). tTGAb (3/119) and TRAb (1/119) were found in low prevalence and 21-OHAb were not detected.
Diabetes associated autoantibodies were detected in the majority of Type 1 DM subjects, suggesting a major role for autoimmunity in the pathogenesis of Type 1 DM in Sri Lankans. The prevalence of TgAb and TPOAb in Type 1 DM subjects and non-diabetic controls was relatively high and similar in both groups.</description><identifier>ISSN: 0391-4097</identifier><identifier>EISSN: 1720-8386</identifier><identifier>DOI: 10.1007/BF03349209</identifier><identifier>PMID: 17259793</identifier><language>eng</language><publisher>Italy</publisher><subject>Adolescent ; Adrenal Glands - immunology ; Adult ; Age of Onset ; Autoantibodies - analysis ; Celiac Disease - epidemiology ; Celiac Disease - immunology ; Child ; Diabetes Mellitus, Type 1 - epidemiology ; Diabetes Mellitus, Type 1 - immunology ; Female ; Glutamate Decarboxylase - immunology ; Humans ; Immunoglobulins, Thyroid-Stimulating ; Insulin Antibodies - analysis ; Iodide Peroxidase - immunology ; Islets of Langerhans - immunology ; Isoenzymes - immunology ; Male ; Prevalence ; Protein Tyrosine Phosphatase, Non-Receptor Type 1 ; Protein Tyrosine Phosphatases - immunology ; Sri Lanka - epidemiology ; Steroid 21-Hydroxylase - immunology ; Thyroid Gland - immunology ; Transglutaminases - immunology</subject><ispartof>Journal of endocrinological investigation, 2006-12, Vol.29 (11), p.968-974</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c285t-1e57e636613ce77cfc03440a4dcdc2bd2102a90c81b9956597c583ac2f5be0c53</citedby><cites>FETCH-LOGICAL-c285t-1e57e636613ce77cfc03440a4dcdc2bd2102a90c81b9956597c583ac2f5be0c53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17259793$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Premawardhana, L D K E</creatorcontrib><creatorcontrib>Wijeyaratne, C N</creatorcontrib><creatorcontrib>Chen, S</creatorcontrib><creatorcontrib>Wijesuriya, M</creatorcontrib><creatorcontrib>Illangasekera, U</creatorcontrib><creatorcontrib>Brooking, H</creatorcontrib><creatorcontrib>Amoroso, M</creatorcontrib><creatorcontrib>Jeffreys, J</creatorcontrib><creatorcontrib>Bolton, J</creatorcontrib><creatorcontrib>Lazarus, J H</creatorcontrib><creatorcontrib>Furmaniak, J</creatorcontrib><creatorcontrib>Rees Smith, B</creatorcontrib><title>Islet cell, thyroid, adrenal and celiac disease related autoantibodies in patients with Type 1 diabetes from Sri Lanka</title><title>Journal of endocrinological investigation</title><addtitle>J Endocrinol Invest</addtitle><description>The prevalence of islet cell, thyroid, adrenal and celiac disease related autoantibodies in patients with Type 1 diabetes mellitus (Type 1 DM) from Sri Lanka is described.
Autoantibodies to glutamic acid decarboxylase 65 (GAD65Ab), protein tyrosine phosphatase IA-2 (IA-2Ab), insulin (IAAb), thyroglobulin (TgAb), thyroid peroxidase (TPOAb), TSH receptor (TRAb), 21-hydroxylase (21-OHAb) and tissue transglutaminase (tTGAb) were measured in 122 Type 1 DM patients who had low C-peptide activity or were >20 yr old at the time of diagnosis and in 100 non-diabetic blood donors.
GAD65Ab and/or IA-2Ab were present in 74/122 (60.7%) Type 1 DM subjects with a significantly higher prevalence compared to non-diabetic controls (no. 100) (GAD65Ab-59 vs 4%; IA-2Ab-14 vs 0%; respectively) (p<0.001). The median (inter-quartile range) Type 1 DM duration in antibody positive subjects was 3.3 (0.99-6.9) vs 4.9 (1.7-7.5) yr in antibody negative subjects (p=0.23). IA-2Ab prevalence decreased with disease duration > or =5 yr (19 vs 4%) (p<0.001). There was no difference in the prevalence of TgAb (25 vs 33%)(p=0.21) and TPOAb (22 vs 18%) (p=0.48) in Type 1 DM and non-diabetic subjects. Also, there was no difference in TgAb and TPOAb prevalence in antibody positive Type 1 DM (34.7%) compared to antibody negative Type 1 DM (24.4%) subjects (p=0.24). tTGAb (3/119) and TRAb (1/119) were found in low prevalence and 21-OHAb were not detected.
Diabetes associated autoantibodies were detected in the majority of Type 1 DM subjects, suggesting a major role for autoimmunity in the pathogenesis of Type 1 DM in Sri Lankans. The prevalence of TgAb and TPOAb in Type 1 DM subjects and non-diabetic controls was relatively high and similar in both groups.</description><subject>Adolescent</subject><subject>Adrenal Glands - immunology</subject><subject>Adult</subject><subject>Age of Onset</subject><subject>Autoantibodies - analysis</subject><subject>Celiac Disease - epidemiology</subject><subject>Celiac Disease - immunology</subject><subject>Child</subject><subject>Diabetes Mellitus, Type 1 - epidemiology</subject><subject>Diabetes Mellitus, Type 1 - immunology</subject><subject>Female</subject><subject>Glutamate Decarboxylase - immunology</subject><subject>Humans</subject><subject>Immunoglobulins, Thyroid-Stimulating</subject><subject>Insulin Antibodies - analysis</subject><subject>Iodide Peroxidase - immunology</subject><subject>Islets of Langerhans - immunology</subject><subject>Isoenzymes - immunology</subject><subject>Male</subject><subject>Prevalence</subject><subject>Protein Tyrosine Phosphatase, Non-Receptor Type 1</subject><subject>Protein Tyrosine Phosphatases - immunology</subject><subject>Sri Lanka - epidemiology</subject><subject>Steroid 21-Hydroxylase - immunology</subject><subject>Thyroid Gland - immunology</subject><subject>Transglutaminases - immunology</subject><issn>0391-4097</issn><issn>1720-8386</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkDFPwzAQhS0EoqWw8AOQJwbUwDlO4ngERAGpEgMwRxf7IgxpUmwH1H9PqlZiuuG-96T3MXYu4FoAqJu7BUiZ6RT0AZsKlUJSyrI4ZFOQWiQZaDVhJyF8AkglS3XMJiOUa6XllP08h5YiN9S2cx4_Nr53ds7Reuqw5djZ7cuh4dYFwkDcU4uRLMch9thFV_fWUeCu42uMjroY-K-LH_xtsyYuxhjWFEeg8f2Kv3rHl9h94Sk7arANdLa_M_a-eHi7f0qWL4_P97fLxKRlHhNBuaJCFoWQhpQyjQGZZYCZNdaktU0FpKjBlKLWOi_GTSYvJZq0yWsCk8sZu9z1rn3_PVCI1cqF7VjsqB9CVZQSUpWLEbzagcb3IXhqqrV3K_SbSkC1tVz9Wx7hi33rUK_I_qN7rfIP8vd3fw</recordid><startdate>20061201</startdate><enddate>20061201</enddate><creator>Premawardhana, L D K E</creator><creator>Wijeyaratne, C N</creator><creator>Chen, S</creator><creator>Wijesuriya, M</creator><creator>Illangasekera, U</creator><creator>Brooking, H</creator><creator>Amoroso, M</creator><creator>Jeffreys, J</creator><creator>Bolton, J</creator><creator>Lazarus, J H</creator><creator>Furmaniak, J</creator><creator>Rees Smith, B</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20061201</creationdate><title>Islet cell, thyroid, adrenal and celiac disease related autoantibodies in patients with Type 1 diabetes from Sri Lanka</title><author>Premawardhana, L D K E ; Wijeyaratne, C N ; Chen, S ; Wijesuriya, M ; Illangasekera, U ; Brooking, H ; Amoroso, M ; Jeffreys, J ; Bolton, J ; Lazarus, J H ; Furmaniak, J ; Rees Smith, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c285t-1e57e636613ce77cfc03440a4dcdc2bd2102a90c81b9956597c583ac2f5be0c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adolescent</topic><topic>Adrenal Glands - immunology</topic><topic>Adult</topic><topic>Age of Onset</topic><topic>Autoantibodies - analysis</topic><topic>Celiac Disease - epidemiology</topic><topic>Celiac Disease - immunology</topic><topic>Child</topic><topic>Diabetes Mellitus, Type 1 - epidemiology</topic><topic>Diabetes Mellitus, Type 1 - immunology</topic><topic>Female</topic><topic>Glutamate Decarboxylase - immunology</topic><topic>Humans</topic><topic>Immunoglobulins, Thyroid-Stimulating</topic><topic>Insulin Antibodies - analysis</topic><topic>Iodide Peroxidase - immunology</topic><topic>Islets of Langerhans - immunology</topic><topic>Isoenzymes - immunology</topic><topic>Male</topic><topic>Prevalence</topic><topic>Protein Tyrosine Phosphatase, Non-Receptor Type 1</topic><topic>Protein Tyrosine Phosphatases - immunology</topic><topic>Sri Lanka - epidemiology</topic><topic>Steroid 21-Hydroxylase - immunology</topic><topic>Thyroid Gland - immunology</topic><topic>Transglutaminases - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Premawardhana, L D K E</creatorcontrib><creatorcontrib>Wijeyaratne, C N</creatorcontrib><creatorcontrib>Chen, S</creatorcontrib><creatorcontrib>Wijesuriya, M</creatorcontrib><creatorcontrib>Illangasekera, U</creatorcontrib><creatorcontrib>Brooking, H</creatorcontrib><creatorcontrib>Amoroso, M</creatorcontrib><creatorcontrib>Jeffreys, J</creatorcontrib><creatorcontrib>Bolton, J</creatorcontrib><creatorcontrib>Lazarus, J H</creatorcontrib><creatorcontrib>Furmaniak, J</creatorcontrib><creatorcontrib>Rees Smith, B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of endocrinological investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Premawardhana, L D K E</au><au>Wijeyaratne, C N</au><au>Chen, S</au><au>Wijesuriya, M</au><au>Illangasekera, U</au><au>Brooking, H</au><au>Amoroso, M</au><au>Jeffreys, J</au><au>Bolton, J</au><au>Lazarus, J H</au><au>Furmaniak, J</au><au>Rees Smith, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Islet cell, thyroid, adrenal and celiac disease related autoantibodies in patients with Type 1 diabetes from Sri Lanka</atitle><jtitle>Journal of endocrinological investigation</jtitle><addtitle>J Endocrinol Invest</addtitle><date>2006-12-01</date><risdate>2006</risdate><volume>29</volume><issue>11</issue><spage>968</spage><epage>974</epage><pages>968-974</pages><issn>0391-4097</issn><eissn>1720-8386</eissn><abstract>The prevalence of islet cell, thyroid, adrenal and celiac disease related autoantibodies in patients with Type 1 diabetes mellitus (Type 1 DM) from Sri Lanka is described.
Autoantibodies to glutamic acid decarboxylase 65 (GAD65Ab), protein tyrosine phosphatase IA-2 (IA-2Ab), insulin (IAAb), thyroglobulin (TgAb), thyroid peroxidase (TPOAb), TSH receptor (TRAb), 21-hydroxylase (21-OHAb) and tissue transglutaminase (tTGAb) were measured in 122 Type 1 DM patients who had low C-peptide activity or were >20 yr old at the time of diagnosis and in 100 non-diabetic blood donors.
GAD65Ab and/or IA-2Ab were present in 74/122 (60.7%) Type 1 DM subjects with a significantly higher prevalence compared to non-diabetic controls (no. 100) (GAD65Ab-59 vs 4%; IA-2Ab-14 vs 0%; respectively) (p<0.001). The median (inter-quartile range) Type 1 DM duration in antibody positive subjects was 3.3 (0.99-6.9) vs 4.9 (1.7-7.5) yr in antibody negative subjects (p=0.23). IA-2Ab prevalence decreased with disease duration > or =5 yr (19 vs 4%) (p<0.001). There was no difference in the prevalence of TgAb (25 vs 33%)(p=0.21) and TPOAb (22 vs 18%) (p=0.48) in Type 1 DM and non-diabetic subjects. Also, there was no difference in TgAb and TPOAb prevalence in antibody positive Type 1 DM (34.7%) compared to antibody negative Type 1 DM (24.4%) subjects (p=0.24). tTGAb (3/119) and TRAb (1/119) were found in low prevalence and 21-OHAb were not detected.
Diabetes associated autoantibodies were detected in the majority of Type 1 DM subjects, suggesting a major role for autoimmunity in the pathogenesis of Type 1 DM in Sri Lankans. The prevalence of TgAb and TPOAb in Type 1 DM subjects and non-diabetic controls was relatively high and similar in both groups.</abstract><cop>Italy</cop><pmid>17259793</pmid><doi>10.1007/BF03349209</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Adrenal Glands - immunology Adult Age of Onset Autoantibodies - analysis Celiac Disease - epidemiology Celiac Disease - immunology Child Diabetes Mellitus, Type 1 - epidemiology Diabetes Mellitus, Type 1 - immunology Female Glutamate Decarboxylase - immunology Humans Immunoglobulins, Thyroid-Stimulating Insulin Antibodies - analysis Iodide Peroxidase - immunology Islets of Langerhans - immunology Isoenzymes - immunology Male Prevalence Protein Tyrosine Phosphatase, Non-Receptor Type 1 Protein Tyrosine Phosphatases - immunology Sri Lanka - epidemiology Steroid 21-Hydroxylase - immunology Thyroid Gland - immunology Transglutaminases - immunology |
| title | Islet cell, thyroid, adrenal and celiac disease related autoantibodies in patients with Type 1 diabetes from Sri Lanka |
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