Relationship between the Thromboxane A2 Receptor Gene and Susceptibility to Cerebral Infarction
The risk of cerebral infarction (CI) in an individual is dependent on the interplay between genetic risk factors and environmental influences. Binding of thromboxane A 2 (TXA 2 ) to its receptor (TP) modulates thrombosis/hemostasis and plays a significant role in the pathogenesis of CI. The aim of t...
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| Veröffentlicht in: | Hypertension research 2006-09, Vol.29 (9), p.665-671 |
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| creator | Kaneko, Yoshiyuki Nakayama, Tomohiro Saito, Kosuke Morita, Akihiko Sato, Ichiro Maruyama, Aya Soma, Masayoshi Takahashi, Teruyuki Sato, Naoyuki |
| description | The risk of cerebral infarction (CI) in an individual is dependent on the interplay between genetic risk factors and environmental influences. Binding of thromboxane A
2
(TXA
2
) to its receptor (TP) modulates thrombosis/hemostasis and plays a significant role in the pathogenesis of CI. The aim of the present study was to investigate the relationship between human TP gene single nucleotide polymorphisms (SNPs) and haplotypes and CI in a Japanese population. A genetic association study was performed in 194 CI patients and 365 non-CI subjects by specifically characterizing 6 SNPs in the human TP gene (rs2271875, rs768963, rs2238634, rs11085026, rs4523 and rs4806942). Analysis demonstrated that there were significant differences in the overall distribution of genotypes and dominant or recessive models of rs2271875 and rs768963 between the CI and the non-CI groups. Multiple logistic regression analysis revealed that the C allele of rs768963 was significantly associated with CI (
p
=0.029), even after adjusting for confounding factors (odds ratio: 2.41). Further, the C-T-C haplotype of rs768963-rs2238634-rs4806942 was significantly more frequent in the CI group (23.0%) than in the non-CI group (17.7%). These results suggest that specific SNPs and haplotypes may have utility as genetic markers for the risk of CI and that TP or a neighboring gene is associated with the increased susceptibility to CI. |
| doi_str_mv | 10.1291/hypres.29.665 |
| format | Article |
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2
(TXA
2
) to its receptor (TP) modulates thrombosis/hemostasis and plays a significant role in the pathogenesis of CI. The aim of the present study was to investigate the relationship between human TP gene single nucleotide polymorphisms (SNPs) and haplotypes and CI in a Japanese population. A genetic association study was performed in 194 CI patients and 365 non-CI subjects by specifically characterizing 6 SNPs in the human TP gene (rs2271875, rs768963, rs2238634, rs11085026, rs4523 and rs4806942). Analysis demonstrated that there were significant differences in the overall distribution of genotypes and dominant or recessive models of rs2271875 and rs768963 between the CI and the non-CI groups. Multiple logistic regression analysis revealed that the C allele of rs768963 was significantly associated with CI (
p
=0.029), even after adjusting for confounding factors (odds ratio: 2.41). Further, the C-T-C haplotype of rs768963-rs2238634-rs4806942 was significantly more frequent in the CI group (23.0%) than in the non-CI group (17.7%). These results suggest that specific SNPs and haplotypes may have utility as genetic markers for the risk of CI and that TP or a neighboring gene is associated with the increased susceptibility to CI.</description><identifier>ISSN: 0916-9636</identifier><identifier>EISSN: 1348-4214</identifier><identifier>DOI: 10.1291/hypres.29.665</identifier><identifier>PMID: 17249521</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Aged ; Aged, 80 and over ; Asian Continental Ancestry Group ; Cerebral Infarction - genetics ; Genetic Predisposition to Disease ; Geriatrics/Gerontology ; Haplotypes ; Health Promotion and Disease Prevention ; Humans ; Internal Medicine ; Medicine ; Medicine & Public Health ; Middle Aged ; Obstetrics/Perinatology/Midwifery ; original-article ; Polymorphism, Single Nucleotide ; Public Health ; Receptors, Thromboxane A2, Prostaglandin H2 - genetics</subject><ispartof>Hypertension research, 2006-09, Vol.29 (9), p.665-671</ispartof><rights>The Japanese Society of Hypertension 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3085-aa1f897e2df57b36af0688e0d51ec647f15a9ac7ecf60c3854bcd56ec37753923</citedby><cites>FETCH-LOGICAL-c3085-aa1f897e2df57b36af0688e0d51ec647f15a9ac7ecf60c3854bcd56ec37753923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17249521$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kaneko, Yoshiyuki</creatorcontrib><creatorcontrib>Nakayama, Tomohiro</creatorcontrib><creatorcontrib>Saito, Kosuke</creatorcontrib><creatorcontrib>Morita, Akihiko</creatorcontrib><creatorcontrib>Sato, Ichiro</creatorcontrib><creatorcontrib>Maruyama, Aya</creatorcontrib><creatorcontrib>Soma, Masayoshi</creatorcontrib><creatorcontrib>Takahashi, Teruyuki</creatorcontrib><creatorcontrib>Sato, Naoyuki</creatorcontrib><title>Relationship between the Thromboxane A2 Receptor Gene and Susceptibility to Cerebral Infarction</title><title>Hypertension research</title><addtitle>Hypertens Res</addtitle><addtitle>Hypertens Res</addtitle><description>The risk of cerebral infarction (CI) in an individual is dependent on the interplay between genetic risk factors and environmental influences. Binding of thromboxane A
2
(TXA
2
) to its receptor (TP) modulates thrombosis/hemostasis and plays a significant role in the pathogenesis of CI. The aim of the present study was to investigate the relationship between human TP gene single nucleotide polymorphisms (SNPs) and haplotypes and CI in a Japanese population. A genetic association study was performed in 194 CI patients and 365 non-CI subjects by specifically characterizing 6 SNPs in the human TP gene (rs2271875, rs768963, rs2238634, rs11085026, rs4523 and rs4806942). Analysis demonstrated that there were significant differences in the overall distribution of genotypes and dominant or recessive models of rs2271875 and rs768963 between the CI and the non-CI groups. Multiple logistic regression analysis revealed that the C allele of rs768963 was significantly associated with CI (
p
=0.029), even after adjusting for confounding factors (odds ratio: 2.41). Further, the C-T-C haplotype of rs768963-rs2238634-rs4806942 was significantly more frequent in the CI group (23.0%) than in the non-CI group (17.7%). These results suggest that specific SNPs and haplotypes may have utility as genetic markers for the risk of CI and that TP or a neighboring gene is associated with the increased susceptibility to CI.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Asian Continental Ancestry Group</subject><subject>Cerebral Infarction - genetics</subject><subject>Genetic Predisposition to Disease</subject><subject>Geriatrics/Gerontology</subject><subject>Haplotypes</subject><subject>Health Promotion and Disease Prevention</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Obstetrics/Perinatology/Midwifery</subject><subject>original-article</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Public Health</subject><subject>Receptors, Thromboxane A2, Prostaglandin H2 - genetics</subject><issn>0916-9636</issn><issn>1348-4214</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM9LwzAUx4Mobk6PXiUnb5350aTNcQydg4Ew5zmk6avr6JqatOj-ezM28OTpwfd9-PLeB6F7SqaUKfq0PXQewpSpqZTiAo0pT_MkZTS9RGOiqEyU5HKEbkLYEcJyoeg1GtGMpUowOkZ6DY3pa9eGbd3hAvpvgBb3W8CbrXf7wv2YFvCM4TVY6Hrn8QJiYNoSvw_hGNVF3dT9AfcOz8FD4U2Dl21lvD3W3qKryjQB7s5zgj5enjfz12T1tljOZ6vEcpKLxBha5SoDVlYiK7g0FZF5DqQUFKxMs4oKo4zNwFaSWJ6LtLClkGB5lgmuGJ-gx1Nv593XAKHX-zqe1zTxfDcELXNOqFJZBJMTaL0LwUOlO1_vjT9oSvTRqD4Z1UzpaDTyD-fiodhD-UefFUZgegJCXLWf4PXODb6Nz_7T-Av9kYQL</recordid><startdate>20060901</startdate><enddate>20060901</enddate><creator>Kaneko, Yoshiyuki</creator><creator>Nakayama, Tomohiro</creator><creator>Saito, Kosuke</creator><creator>Morita, Akihiko</creator><creator>Sato, Ichiro</creator><creator>Maruyama, Aya</creator><creator>Soma, Masayoshi</creator><creator>Takahashi, Teruyuki</creator><creator>Sato, Naoyuki</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060901</creationdate><title>Relationship between the Thromboxane A2 Receptor Gene and Susceptibility to Cerebral Infarction</title><author>Kaneko, Yoshiyuki ; Nakayama, Tomohiro ; Saito, Kosuke ; Morita, Akihiko ; Sato, Ichiro ; Maruyama, Aya ; Soma, Masayoshi ; Takahashi, Teruyuki ; Sato, Naoyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3085-aa1f897e2df57b36af0688e0d51ec647f15a9ac7ecf60c3854bcd56ec37753923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Asian Continental Ancestry Group</topic><topic>Cerebral Infarction - genetics</topic><topic>Genetic Predisposition to Disease</topic><topic>Geriatrics/Gerontology</topic><topic>Haplotypes</topic><topic>Health Promotion and Disease Prevention</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Obstetrics/Perinatology/Midwifery</topic><topic>original-article</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Public Health</topic><topic>Receptors, Thromboxane A2, Prostaglandin H2 - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kaneko, Yoshiyuki</creatorcontrib><creatorcontrib>Nakayama, Tomohiro</creatorcontrib><creatorcontrib>Saito, Kosuke</creatorcontrib><creatorcontrib>Morita, Akihiko</creatorcontrib><creatorcontrib>Sato, Ichiro</creatorcontrib><creatorcontrib>Maruyama, Aya</creatorcontrib><creatorcontrib>Soma, Masayoshi</creatorcontrib><creatorcontrib>Takahashi, Teruyuki</creatorcontrib><creatorcontrib>Sato, Naoyuki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hypertension research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kaneko, Yoshiyuki</au><au>Nakayama, Tomohiro</au><au>Saito, Kosuke</au><au>Morita, Akihiko</au><au>Sato, Ichiro</au><au>Maruyama, Aya</au><au>Soma, Masayoshi</au><au>Takahashi, Teruyuki</au><au>Sato, Naoyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between the Thromboxane A2 Receptor Gene and Susceptibility to Cerebral Infarction</atitle><jtitle>Hypertension research</jtitle><stitle>Hypertens Res</stitle><addtitle>Hypertens Res</addtitle><date>2006-09-01</date><risdate>2006</risdate><volume>29</volume><issue>9</issue><spage>665</spage><epage>671</epage><pages>665-671</pages><issn>0916-9636</issn><eissn>1348-4214</eissn><abstract>The risk of cerebral infarction (CI) in an individual is dependent on the interplay between genetic risk factors and environmental influences. Binding of thromboxane A
2
(TXA
2
) to its receptor (TP) modulates thrombosis/hemostasis and plays a significant role in the pathogenesis of CI. The aim of the present study was to investigate the relationship between human TP gene single nucleotide polymorphisms (SNPs) and haplotypes and CI in a Japanese population. A genetic association study was performed in 194 CI patients and 365 non-CI subjects by specifically characterizing 6 SNPs in the human TP gene (rs2271875, rs768963, rs2238634, rs11085026, rs4523 and rs4806942). Analysis demonstrated that there were significant differences in the overall distribution of genotypes and dominant or recessive models of rs2271875 and rs768963 between the CI and the non-CI groups. Multiple logistic regression analysis revealed that the C allele of rs768963 was significantly associated with CI (
p
=0.029), even after adjusting for confounding factors (odds ratio: 2.41). Further, the C-T-C haplotype of rs768963-rs2238634-rs4806942 was significantly more frequent in the CI group (23.0%) than in the non-CI group (17.7%). These results suggest that specific SNPs and haplotypes may have utility as genetic markers for the risk of CI and that TP or a neighboring gene is associated with the increased susceptibility to CI.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>17249521</pmid><doi>10.1291/hypres.29.665</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aged, 80 and over Asian Continental Ancestry Group Cerebral Infarction - genetics Genetic Predisposition to Disease Geriatrics/Gerontology Haplotypes Health Promotion and Disease Prevention Humans Internal Medicine Medicine Medicine & Public Health Middle Aged Obstetrics/Perinatology/Midwifery original-article Polymorphism, Single Nucleotide Public Health Receptors, Thromboxane A2, Prostaglandin H2 - genetics |
| title | Relationship between the Thromboxane A2 Receptor Gene and Susceptibility to Cerebral Infarction |
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