Biological evaluation of anti-influenza viral activity of semi-synthetic catechin derivatives

Catechin derivatives with different alkyl chain length and aromatic ring substitutions at the 3-hydroxyl group were synthesized from epigallocatechin (EGC) and (+)-catechin (C) and their anti-influenza viral activity were evaluated in vitro and in ovo. Pronounced antiviral activity was observed for...

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Veröffentlicht in:	Antiviral research 2007-11, Vol.76 (2), p.178-185
Hauptverfasser:	Song, Jae Min, Park, Ki Duk, Lee, Kwang Hee, Byun, Young Ho, Park, Ju Hee, Kim, Sung Han, Kim, Jae Hong, Seong, Baik Lin
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkyl chain Amantadine - pharmacology Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Avian influenza virus Biological and medical sciences Catechin - analogs & derivatives Catechin - chemical synthesis Catechin - chemistry Catechin - pharmacology Catechin derivatives Cell Line Chickens Dogs Drug Evaluation, Preclinical Eggs - virology Hemagglutination Inhibition Tests Hemagglutinin Human viral diseases Infectious diseases Influenza A Virus, H1N1 Subtype - drug effects Influenza A Virus, H2N2 Subtype - drug effects Influenza A Virus, H3N2 Subtype - drug effects Influenza A Virus, H9N2 Subtype - drug effects Influenza B virus - drug effects Influenza virus Medical sciences Molecular Structure Oseltamivir - pharmacology Pharmacology. Drug treatments Structure-Activity Relationship Viral diseases Viral diseases of the respiratory system and ent viral diseases Viral Plaque Assay Virus Attachment - drug effects Virus Internalization - drug effects Virus Replication - drug effects
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