Acute basophilic leukaemia: a case report
Acute basophilic leukaemia is an uncommon form of acute leukaemia, rarely occurring as de novo disease. Due to rarity of the disease, consistent diagnostic criteria for the identification of this entity still remain the topic of discussion. Immunophenotypic profile, electron microscopy and cytogenet...
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| Veröffentlicht in: | Indian journal of pathology & microbiology 2007-04, Vol.50 (2), p.443-446 |
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| container_title | Indian journal of pathology & microbiology |
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| creator | Kokandakar, H R Tembhare, P R Mamoon, Alfatmi Mulay, V M Bhople, K S |
| description | Acute basophilic leukaemia is an uncommon form of acute leukaemia, rarely occurring as de novo disease. Due to rarity of the disease, consistent diagnostic criteria for the identification of this entity still remain the topic of discussion. Immunophenotypic profile, electron microscopy and cytogenetic analysis in addition to morphological features, are said to be highly desirable for correct identification of this entity. In set-up like ours, where such facilities are either not available or not in reach of the patients due to financial constraints, morphological features and simple technique like demonstration of metachromasia in blasts with toluidine blue stain remain the most useful diagnostic tool for identification of this rare condition. We present a case of acute basophilic leukaemia with (11q23)-MLL gene rearrangement, in an 18-year-old male with review of literature and discussion of diagnostic criteria. |
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| ispartof | Indian journal of pathology & microbiology, 2007-04, Vol.50 (2), p.443-446 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Coloring Agents Gene Rearrangement Histone-Lysine N-Methyltransferase Humans Leukemia, Basophilic, Acute - diagnosis Leukemia, Basophilic, Acute - genetics Leukemia, Basophilic, Acute - pathology Male Myeloid-Lymphoid Leukemia Protein - genetics Staining and Labeling Tolonium Chloride |
| title | Acute basophilic leukaemia: a case report |
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