Association between the polymorphism of TGF-beta1 gene promoter (-509C>T) and idiopathic chronic urticaria
Idiopathic Chronic Urticaria (ICU), the most common form (70-80%) of chronic urticaria is supposed to have immune basis causes. It is speculated that the promoter polymorphism of TGF-Beta1 gene may be involved in ICU. This condition is thought to affect at least 0.1% of the population and often can...
Gespeichert in:
| Veröffentlicht in: | Iranian journal of allergy, asthma, and immunology asthma, and immunology, 2006-09, Vol.5 (3), p.109-113 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 113 |
|---|---|
| container_issue | 3 |
| container_start_page | 109 |
| container_title | Iranian journal of allergy, asthma, and immunology |
| container_volume | 5 |
| creator | Hosseini Farahabadi, Sara Tavakkol-Afshari, Jalil Ganjali, Rashin Rafatpanah, Houshang Ghaffari, Javad Farid-Hosseini, Reza |
| description | Idiopathic Chronic Urticaria (ICU), the most common form (70-80%) of chronic urticaria is supposed to have immune basis causes. It is speculated that the promoter polymorphism of TGF-Beta1 gene may be involved in ICU. This condition is thought to affect at least 0.1% of the population and often can be severe and difficult to treat. A total of 40 patients with ICU and 41 normal subjects were studied. DNA was extracted from whole blood and TGF-Beta1 promoter -509C>T polymorphism was determined by PCR-RFLP method. Out of the 40 patients with ICU, 11 (27.5%) had CC, 26 (65%) had CT and 3 (7.5%) had TT genotypes. A higher proportion of case subjects with the C allele (CT type or CC type) was found compared with the T allele. These results do suggest an influence of genetic variability at the promoter of TGF-Beta1 gene (-509C>T) on the occurrence of ICU. This polymorphism has been shown as a useful genetic change in our study. Further work is required to confirm this result. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_68298188</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68298188</sourcerecordid><originalsourceid>FETCH-LOGICAL-p541-4415f9bc5ad55221ccf038943a5da353ea013861fbd0c2c4cdc6998802799d1b3</originalsourceid><addsrcrecordid>eNo1kE9LwzAchnNQ3Jx-BclJ9FDIn6ZNLsIYbgoDL72XX5PUZrRNTVJk396C2-k9PA8vL-8NWtOSi4wKwlboPsYTIaJQhN2hFS0ZL0VB1-i0jdFrB8n5ETc2_Vo74tRZPPn-PPgwdS4O2Le4OuyzhQPF33ZccPCDTzbgl0wQtXurXjGMBjvj_ASpcxrrLvhxyTkkpyE4eEC3LfTRPl5yg6r9e7X7yI5fh8_d9phNIqdZnlPRqkYLMEIwRrVuCZcq5yAMcMEtEMplQdvGEM10ro0ulJKSsFIpQxu-Qc__tcvEn9nGVA8uatv3MFo_x7qQTEkq5SI-XcS5Gaypp-AGCOf6eg7_A_2-Xw0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68298188</pqid></control><display><type>article</type><title>Association between the polymorphism of TGF-beta1 gene promoter (-509C>T) and idiopathic chronic urticaria</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Hosseini Farahabadi, Sara ; Tavakkol-Afshari, Jalil ; Ganjali, Rashin ; Rafatpanah, Houshang ; Ghaffari, Javad ; Farid-Hosseini, Reza</creator><creatorcontrib>Hosseini Farahabadi, Sara ; Tavakkol-Afshari, Jalil ; Ganjali, Rashin ; Rafatpanah, Houshang ; Ghaffari, Javad ; Farid-Hosseini, Reza</creatorcontrib><description>Idiopathic Chronic Urticaria (ICU), the most common form (70-80%) of chronic urticaria is supposed to have immune basis causes. It is speculated that the promoter polymorphism of TGF-Beta1 gene may be involved in ICU. This condition is thought to affect at least 0.1% of the population and often can be severe and difficult to treat. A total of 40 patients with ICU and 41 normal subjects were studied. DNA was extracted from whole blood and TGF-Beta1 promoter -509C>T polymorphism was determined by PCR-RFLP method. Out of the 40 patients with ICU, 11 (27.5%) had CC, 26 (65%) had CT and 3 (7.5%) had TT genotypes. A higher proportion of case subjects with the C allele (CT type or CC type) was found compared with the T allele. These results do suggest an influence of genetic variability at the promoter of TGF-Beta1 gene (-509C>T) on the occurrence of ICU. This polymorphism has been shown as a useful genetic change in our study. Further work is required to confirm this result.</description><identifier>ISSN: 1735-1502</identifier><identifier>PMID: 17237561</identifier><language>eng</language><publisher>Iran</publisher><subject>Adult ; Case-Control Studies ; Female ; Humans ; Iran - epidemiology ; Male ; Polymorphism, Single Nucleotide ; Promoter Regions, Genetic ; Transforming Growth Factor beta1 - genetics ; Urticaria - epidemiology ; Urticaria - genetics</subject><ispartof>Iranian journal of allergy, asthma, and immunology, 2006-09, Vol.5 (3), p.109-113</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17237561$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hosseini Farahabadi, Sara</creatorcontrib><creatorcontrib>Tavakkol-Afshari, Jalil</creatorcontrib><creatorcontrib>Ganjali, Rashin</creatorcontrib><creatorcontrib>Rafatpanah, Houshang</creatorcontrib><creatorcontrib>Ghaffari, Javad</creatorcontrib><creatorcontrib>Farid-Hosseini, Reza</creatorcontrib><title>Association between the polymorphism of TGF-beta1 gene promoter (-509C>T) and idiopathic chronic urticaria</title><title>Iranian journal of allergy, asthma, and immunology</title><addtitle>Iran J Allergy Asthma Immunol</addtitle><description>Idiopathic Chronic Urticaria (ICU), the most common form (70-80%) of chronic urticaria is supposed to have immune basis causes. It is speculated that the promoter polymorphism of TGF-Beta1 gene may be involved in ICU. This condition is thought to affect at least 0.1% of the population and often can be severe and difficult to treat. A total of 40 patients with ICU and 41 normal subjects were studied. DNA was extracted from whole blood and TGF-Beta1 promoter -509C>T polymorphism was determined by PCR-RFLP method. Out of the 40 patients with ICU, 11 (27.5%) had CC, 26 (65%) had CT and 3 (7.5%) had TT genotypes. A higher proportion of case subjects with the C allele (CT type or CC type) was found compared with the T allele. These results do suggest an influence of genetic variability at the promoter of TGF-Beta1 gene (-509C>T) on the occurrence of ICU. This polymorphism has been shown as a useful genetic change in our study. Further work is required to confirm this result.</description><subject>Adult</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Iran - epidemiology</subject><subject>Male</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Promoter Regions, Genetic</subject><subject>Transforming Growth Factor beta1 - genetics</subject><subject>Urticaria - epidemiology</subject><subject>Urticaria - genetics</subject><issn>1735-1502</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kE9LwzAchnNQ3Jx-BclJ9FDIn6ZNLsIYbgoDL72XX5PUZrRNTVJk396C2-k9PA8vL-8NWtOSi4wKwlboPsYTIaJQhN2hFS0ZL0VB1-i0jdFrB8n5ETc2_Vo74tRZPPn-PPgwdS4O2Le4OuyzhQPF33ZccPCDTzbgl0wQtXurXjGMBjvj_ASpcxrrLvhxyTkkpyE4eEC3LfTRPl5yg6r9e7X7yI5fh8_d9phNIqdZnlPRqkYLMEIwRrVuCZcq5yAMcMEtEMplQdvGEM10ro0ulJKSsFIpQxu-Qc__tcvEn9nGVA8uatv3MFo_x7qQTEkq5SI-XcS5Gaypp-AGCOf6eg7_A_2-Xw0</recordid><startdate>200609</startdate><enddate>200609</enddate><creator>Hosseini Farahabadi, Sara</creator><creator>Tavakkol-Afshari, Jalil</creator><creator>Ganjali, Rashin</creator><creator>Rafatpanah, Houshang</creator><creator>Ghaffari, Javad</creator><creator>Farid-Hosseini, Reza</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200609</creationdate><title>Association between the polymorphism of TGF-beta1 gene promoter (-509C>T) and idiopathic chronic urticaria</title><author>Hosseini Farahabadi, Sara ; Tavakkol-Afshari, Jalil ; Ganjali, Rashin ; Rafatpanah, Houshang ; Ghaffari, Javad ; Farid-Hosseini, Reza</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p541-4415f9bc5ad55221ccf038943a5da353ea013861fbd0c2c4cdc6998802799d1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Iran - epidemiology</topic><topic>Male</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Promoter Regions, Genetic</topic><topic>Transforming Growth Factor beta1 - genetics</topic><topic>Urticaria - epidemiology</topic><topic>Urticaria - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hosseini Farahabadi, Sara</creatorcontrib><creatorcontrib>Tavakkol-Afshari, Jalil</creatorcontrib><creatorcontrib>Ganjali, Rashin</creatorcontrib><creatorcontrib>Rafatpanah, Houshang</creatorcontrib><creatorcontrib>Ghaffari, Javad</creatorcontrib><creatorcontrib>Farid-Hosseini, Reza</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Iranian journal of allergy, asthma, and immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hosseini Farahabadi, Sara</au><au>Tavakkol-Afshari, Jalil</au><au>Ganjali, Rashin</au><au>Rafatpanah, Houshang</au><au>Ghaffari, Javad</au><au>Farid-Hosseini, Reza</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between the polymorphism of TGF-beta1 gene promoter (-509C>T) and idiopathic chronic urticaria</atitle><jtitle>Iranian journal of allergy, asthma, and immunology</jtitle><addtitle>Iran J Allergy Asthma Immunol</addtitle><date>2006-09</date><risdate>2006</risdate><volume>5</volume><issue>3</issue><spage>109</spage><epage>113</epage><pages>109-113</pages><issn>1735-1502</issn><abstract>Idiopathic Chronic Urticaria (ICU), the most common form (70-80%) of chronic urticaria is supposed to have immune basis causes. It is speculated that the promoter polymorphism of TGF-Beta1 gene may be involved in ICU. This condition is thought to affect at least 0.1% of the population and often can be severe and difficult to treat. A total of 40 patients with ICU and 41 normal subjects were studied. DNA was extracted from whole blood and TGF-Beta1 promoter -509C>T polymorphism was determined by PCR-RFLP method. Out of the 40 patients with ICU, 11 (27.5%) had CC, 26 (65%) had CT and 3 (7.5%) had TT genotypes. A higher proportion of case subjects with the C allele (CT type or CC type) was found compared with the T allele. These results do suggest an influence of genetic variability at the promoter of TGF-Beta1 gene (-509C>T) on the occurrence of ICU. This polymorphism has been shown as a useful genetic change in our study. Further work is required to confirm this result.</abstract><cop>Iran</cop><pmid>17237561</pmid><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1735-1502 |
| ispartof | Iranian journal of allergy, asthma, and immunology, 2006-09, Vol.5 (3), p.109-113 |
| issn | 1735-1502 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68298188 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Case-Control Studies Female Humans Iran - epidemiology Male Polymorphism, Single Nucleotide Promoter Regions, Genetic Transforming Growth Factor beta1 - genetics Urticaria - epidemiology Urticaria - genetics |
| title | Association between the polymorphism of TGF-beta1 gene promoter (-509C>T) and idiopathic chronic urticaria |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-12T12%3A56%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20between%20the%20polymorphism%20of%20TGF-beta1%20gene%20promoter%20(-509C%3ET)%20and%20idiopathic%20chronic%20urticaria&rft.jtitle=Iranian%20journal%20of%20allergy,%20asthma,%20and%20immunology&rft.au=Hosseini%20Farahabadi,%20Sara&rft.date=2006-09&rft.volume=5&rft.issue=3&rft.spage=109&rft.epage=113&rft.pages=109-113&rft.issn=1735-1502&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E68298188%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68298188&rft_id=info:pmid/17237561&rfr_iscdi=true |