Reelin down-regulation in mice and psychosis endophenotypes
Reelin, a large glycoprotein secreted by telencephalic GABAergic neurons, plays an important role in neuronal guidance embryonically and in synaptic plasticity postnatally. The reeler heterozygous mouse (+/rl) appears superficially normal but has been of interest as an animal model for psychosis sin...
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| Veröffentlicht in: | Neuroscience and biobehavioral reviews 2006, Vol.30 (8), p.1065-1077 |
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| creator | Tueting, Patricia Doueiri, Mohemed-Salim Guidotti, Alessandro Davis, John M. Costa, Erminio |
| description | Reelin, a large glycoprotein secreted by telencephalic GABAergic neurons, plays an important role in neuronal guidance embryonically and in synaptic plasticity postnatally. The reeler heterozygous mouse (+/rl) appears superficially normal but has been of interest as an animal model for psychosis since the discovery that reelin is 50% down-regulated in postmortem psychotic brain. Brain abnormalities in +/rl are similar to psychotic brain and include a reduction in glutamic acid de carboxylase 67 (
GAD
67), dendritic arbors and spine density in cortex and hippocampus, and abnormalities in synaptic function including long-term potentiation (LTP). In spite of these abnormalities, behavioral abnormalities in +/rl are subtle and controversial. Recent findings indicate that the reelin (
RELN) and
GAD
67 promoters are hypermethylated in GABAergic neurons of psychotic postmortem brain and that DNA methyltransferase 1 (DNMT1) is up-regulated. Hypermethlyation of
RELN and
GAD
67 promoters can be induced by treating mice with methionine, and these mice display brain and behavioral abnormalities similar to +/rl. Thus, an animal model that combines genetic heterozygocity with epigenesis holds promise for understanding the role of Reelin down-regulation in psychosis |
| doi_str_mv | 10.1016/j.neubiorev.2006.04.001 |
| format | Article |
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GAD
67), dendritic arbors and spine density in cortex and hippocampus, and abnormalities in synaptic function including long-term potentiation (LTP). In spite of these abnormalities, behavioral abnormalities in +/rl are subtle and controversial. Recent findings indicate that the reelin (
RELN) and
GAD
67 promoters are hypermethylated in GABAergic neurons of psychotic postmortem brain and that DNA methyltransferase 1 (DNMT1) is up-regulated. Hypermethlyation of
RELN and
GAD
67 promoters can be induced by treating mice with methionine, and these mice display brain and behavioral abnormalities similar to +/rl. Thus, an animal model that combines genetic heterozygocity with epigenesis holds promise for understanding the role of Reelin down-regulation in psychosis</description><identifier>ISSN: 0149-7634</identifier><identifier>EISSN: 1873-7528</identifier><identifier>DOI: 10.1016/j.neubiorev.2006.04.001</identifier><identifier>PMID: 16769115</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Behavior, Animal ; Behavioral psychophysiology ; Biological and medical sciences ; Brain - metabolism ; Brain - pathology ; Brain - physiopathology ; Cell Adhesion Molecules, Neuronal - metabolism ; Disease Models, Animal ; Down-Regulation - physiology ; Endophenotype ; Epigenetic ; Extracellular Matrix Proteins - metabolism ; Fundamental and applied biological sciences. Psychology ; GABA ; GAD67 ; gamma-Aminobutyric Acid - metabolism ; Glutamate Decarboxylase - metabolism ; Humans ; Isoenzymes - metabolism ; Methionine ; Methylation ; Mice ; Nerve Tissue Proteins - metabolism ; Neurons - physiology ; NMDA receptor ; Phenotype ; Prepulse inhibition of startle ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Psychotic Disorders - metabolism ; Reeler heterozygous mouse ; Reelin ; RELN ; Serine Endopeptidases - metabolism</subject><ispartof>Neuroscience and biobehavioral reviews, 2006, Vol.30 (8), p.1065-1077</ispartof><rights>2006 Elsevier Ltd</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c345t-792186280dc05cae6444d9393a2080b2687cfb4495a8bb35a7fde8100af5c7963</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0149763406000388$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18356036$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16769115$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tueting, Patricia</creatorcontrib><creatorcontrib>Doueiri, Mohemed-Salim</creatorcontrib><creatorcontrib>Guidotti, Alessandro</creatorcontrib><creatorcontrib>Davis, John M.</creatorcontrib><creatorcontrib>Costa, Erminio</creatorcontrib><title>Reelin down-regulation in mice and psychosis endophenotypes</title><title>Neuroscience and biobehavioral reviews</title><addtitle>Neurosci Biobehav Rev</addtitle><description>Reelin, a large glycoprotein secreted by telencephalic GABAergic neurons, plays an important role in neuronal guidance embryonically and in synaptic plasticity postnatally. The reeler heterozygous mouse (+/rl) appears superficially normal but has been of interest as an animal model for psychosis since the discovery that reelin is 50% down-regulated in postmortem psychotic brain. Brain abnormalities in +/rl are similar to psychotic brain and include a reduction in glutamic acid de carboxylase 67 (
GAD
67), dendritic arbors and spine density in cortex and hippocampus, and abnormalities in synaptic function including long-term potentiation (LTP). In spite of these abnormalities, behavioral abnormalities in +/rl are subtle and controversial. Recent findings indicate that the reelin (
RELN) and
GAD
67 promoters are hypermethylated in GABAergic neurons of psychotic postmortem brain and that DNA methyltransferase 1 (DNMT1) is up-regulated. Hypermethlyation of
RELN and
GAD
67 promoters can be induced by treating mice with methionine, and these mice display brain and behavioral abnormalities similar to +/rl. Thus, an animal model that combines genetic heterozygocity with epigenesis holds promise for understanding the role of Reelin down-regulation in psychosis</description><subject>Animals</subject><subject>Behavior, Animal</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Brain - pathology</subject><subject>Brain - physiopathology</subject><subject>Cell Adhesion Molecules, Neuronal - metabolism</subject><subject>Disease Models, Animal</subject><subject>Down-Regulation - physiology</subject><subject>Endophenotype</subject><subject>Epigenetic</subject><subject>Extracellular Matrix Proteins - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GABA</subject><subject>GAD67</subject><subject>gamma-Aminobutyric Acid - metabolism</subject><subject>Glutamate Decarboxylase - metabolism</subject><subject>Humans</subject><subject>Isoenzymes - metabolism</subject><subject>Methionine</subject><subject>Methylation</subject><subject>Mice</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>Neurons - physiology</subject><subject>NMDA receptor</subject><subject>Phenotype</subject><subject>Prepulse inhibition of startle</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Psychotic Disorders - metabolism</subject><subject>Reeler heterozygous mouse</subject><subject>Reelin</subject><subject>RELN</subject><subject>Serine Endopeptidases - metabolism</subject><issn>0149-7634</issn><issn>1873-7528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1r3DAQhkVpaDZp_0LrS3uzM_qW6SmEtikECiU5C1keN1q8kivZCfvv62WX5pjTwPC88_EQ8olCQ4Gqq20TcelCyvjUMADVgGgA6BuyoUbzWktm3pINUNHWWnFxTi5K2QIAAy7fkXOqtGoplRvy9TfiGGLVp-dYZ_yzjG4OKVZraxc8Vi721VT2_jGVUCqMfZoeMaZ5P2F5T84GNxb8cKqX5OH7t_ub2_ru14-fN9d3tedCzrVuGTWKGeg9SO9QCSH6lrfcMTDQMWW0HzohWulM13Hp9NCjoQBukF63il-SL8e5U05_Fyyz3YXicRxdxLQUqwxrNZX8VZC2whjJ2ArqI-hzKiXjYKccdi7vLQV7EGy39r9gexBsQdhV8Jr8eFqxdDvsX3Inoyvw-QS44t04ZBd9KC-c4VIBPzx1feRwNfcUMNviA0aPfcjoZ9un8Oox_wDtsZzy</recordid><startdate>2006</startdate><enddate>2006</enddate><creator>Tueting, Patricia</creator><creator>Doueiri, Mohemed-Salim</creator><creator>Guidotti, Alessandro</creator><creator>Davis, John M.</creator><creator>Costa, Erminio</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>2006</creationdate><title>Reelin down-regulation in mice and psychosis endophenotypes</title><author>Tueting, Patricia ; Doueiri, Mohemed-Salim ; Guidotti, Alessandro ; Davis, John M. ; Costa, Erminio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c345t-792186280dc05cae6444d9393a2080b2687cfb4495a8bb35a7fde8100af5c7963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Behavior, Animal</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Brain - pathology</topic><topic>Brain - physiopathology</topic><topic>Cell Adhesion Molecules, Neuronal - metabolism</topic><topic>Disease Models, Animal</topic><topic>Down-Regulation - physiology</topic><topic>Endophenotype</topic><topic>Epigenetic</topic><topic>Extracellular Matrix Proteins - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GABA</topic><topic>GAD67</topic><topic>gamma-Aminobutyric Acid - metabolism</topic><topic>Glutamate Decarboxylase - metabolism</topic><topic>Humans</topic><topic>Isoenzymes - metabolism</topic><topic>Methionine</topic><topic>Methylation</topic><topic>Mice</topic><topic>Nerve Tissue Proteins - metabolism</topic><topic>Neurons - physiology</topic><topic>NMDA receptor</topic><topic>Phenotype</topic><topic>Prepulse inhibition of startle</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Psychotic Disorders - metabolism</topic><topic>Reeler heterozygous mouse</topic><topic>Reelin</topic><topic>RELN</topic><topic>Serine Endopeptidases - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tueting, Patricia</creatorcontrib><creatorcontrib>Doueiri, Mohemed-Salim</creatorcontrib><creatorcontrib>Guidotti, Alessandro</creatorcontrib><creatorcontrib>Davis, John M.</creatorcontrib><creatorcontrib>Costa, Erminio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience and biobehavioral reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tueting, Patricia</au><au>Doueiri, Mohemed-Salim</au><au>Guidotti, Alessandro</au><au>Davis, John M.</au><au>Costa, Erminio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reelin down-regulation in mice and psychosis endophenotypes</atitle><jtitle>Neuroscience and biobehavioral reviews</jtitle><addtitle>Neurosci Biobehav Rev</addtitle><date>2006</date><risdate>2006</risdate><volume>30</volume><issue>8</issue><spage>1065</spage><epage>1077</epage><pages>1065-1077</pages><issn>0149-7634</issn><eissn>1873-7528</eissn><abstract>Reelin, a large glycoprotein secreted by telencephalic GABAergic neurons, plays an important role in neuronal guidance embryonically and in synaptic plasticity postnatally. The reeler heterozygous mouse (+/rl) appears superficially normal but has been of interest as an animal model for psychosis since the discovery that reelin is 50% down-regulated in postmortem psychotic brain. Brain abnormalities in +/rl are similar to psychotic brain and include a reduction in glutamic acid de carboxylase 67 (
GAD
67), dendritic arbors and spine density in cortex and hippocampus, and abnormalities in synaptic function including long-term potentiation (LTP). In spite of these abnormalities, behavioral abnormalities in +/rl are subtle and controversial. Recent findings indicate that the reelin (
RELN) and
GAD
67 promoters are hypermethylated in GABAergic neurons of psychotic postmortem brain and that DNA methyltransferase 1 (DNMT1) is up-regulated. Hypermethlyation of
RELN and
GAD
67 promoters can be induced by treating mice with methionine, and these mice display brain and behavioral abnormalities similar to +/rl. Thus, an animal model that combines genetic heterozygocity with epigenesis holds promise for understanding the role of Reelin down-regulation in psychosis</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>16769115</pmid><doi>10.1016/j.neubiorev.2006.04.001</doi><tpages>13</tpages></addata></record> |
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| subjects | Animals Behavior, Animal Behavioral psychophysiology Biological and medical sciences Brain - metabolism Brain - pathology Brain - physiopathology Cell Adhesion Molecules, Neuronal - metabolism Disease Models, Animal Down-Regulation - physiology Endophenotype Epigenetic Extracellular Matrix Proteins - metabolism Fundamental and applied biological sciences. Psychology GABA GAD67 gamma-Aminobutyric Acid - metabolism Glutamate Decarboxylase - metabolism Humans Isoenzymes - metabolism Methionine Methylation Mice Nerve Tissue Proteins - metabolism Neurons - physiology NMDA receptor Phenotype Prepulse inhibition of startle Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychotic Disorders - metabolism Reeler heterozygous mouse Reelin RELN Serine Endopeptidases - metabolism |
| title | Reelin down-regulation in mice and psychosis endophenotypes |
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