Palmitic acid induces production of proinflammatory cytokine interleukin‐8 from hepatocytes

Obesity and the metabolic syndrome are closely correlated with hepatic steatosis. Simple hepatic steatosis in nonalcoholic fatty liver disease can progress to nonalcoholic steatohepatitis (NASH), which can be a precursor to more serious liver diseases, such as cirrhosis and hepatocellular carcinoma....

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2007-09, Vol.46 (3), p.823-830
Hauptverfasser:	Joshi‐Barve, Swati, Barve, Shirish S., Amancherla, Kiranmayi, Gobejishvili, Leila, Hill, Daniell, Cave, Matthew, Hote, Prachi, McClain, Craig J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell Line, Tumor Chemokines, CXC - metabolism Cytokines - metabolism Fatty Liver - etiology Fatty Liver - metabolism Gastroenterology. Liver. Pancreas. Abdomen Hepatocytes - chemistry Hepatocytes - drug effects Hepatocytes - metabolism Humans Interleukin-8 - genetics Interleukin-8 - metabolism Lipids - analysis Liver. Biliary tract. Portal circulation. Exocrine pancreas MAP Kinase Kinase 4 - antagonists & inhibitors MAP Kinase Kinase 4 - metabolism Medical sciences Metabolic diseases Miscellaneous NF-kappa B - antagonists & inhibitors NF-kappa B - metabolism Obesity Other diseases. Semiology Other metabolic disorders Palmitic Acid - metabolism Palmitic Acid - pharmacology RNA, Messenger - analysis RNA, Messenger - metabolism Transcription Factor AP-1 - metabolism Triglycerides - analysis Triglycerides - metabolism
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