Association of OAZ1 Gene Polymorphisms With Subclinical and Clinical Vascular Events

OBJECTIVE—Proliferation and migration of vascular smooth muscle cells (VSMCs) are striking features shared by vascular ageing, atherosclerosis, and in-stent restenosis. VSMC biology depends in part on polyamines whose metabolism is closely regulated by ornithine decarboxylase antizyme 1 (OAZ1). Ther...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2007-10, Vol.27 (10), p.2120-2126
Hauptverfasser:	Dumont, Julie, Zureik, Mahmoud, Bauters, Christophe, Grupposo, Marie-Catherine, Cottel, Dominique, Montaye, Michèle, Hamon, Martial, Ducimetière, Pierre, Amouyel, Philippe, Brousseau, Thierry
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Associated diseases and complications Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular Diseases - enzymology Cardiovascular Diseases - genetics Cardiovascular Diseases - pathology Carotid Artery Diseases - enzymology Carotid Artery Diseases - genetics Carotid Artery Diseases - pathology Case-Control Studies Cell Proliferation Coronary Disease - enzymology Coronary Disease - genetics Coronary Disease - pathology Coronary Restenosis - enzymology Coronary Restenosis - genetics Coronary Restenosis - pathology Diabetes. Impaired glucose tolerance Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Endocrine pancreas. Apud cells (diseases) Endocrinopathies Female Fundamental and applied biological sciences. Psychology Gene Frequency General aspects Genetic Predisposition to Disease Humans Linkage Disequilibrium Longitudinal Studies Male Medical sciences Middle Aged Muscle, Smooth, Vascular - enzymology Muscle, Smooth, Vascular - pathology Myocytes, Smooth Muscle - enzymology Myocytes, Smooth Muscle - pathology Odds Ratio Phenotype Polyamines - metabolism Polymorphism, Single Nucleotide Proteins - genetics Risk Assessment Risk Factors Vertebrates: cardiovascular system
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