Association of OAZ1 Gene Polymorphisms With Subclinical and Clinical Vascular Events
OBJECTIVE—Proliferation and migration of vascular smooth muscle cells (VSMCs) are striking features shared by vascular ageing, atherosclerosis, and in-stent restenosis. VSMC biology depends in part on polyamines whose metabolism is closely regulated by ornithine decarboxylase antizyme 1 (OAZ1). Ther...
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| Veröffentlicht in: | Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2007-10, Vol.27 (10), p.2120-2126 |
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| container_title | Arteriosclerosis, thrombosis, and vascular biology |
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| creator | Dumont, Julie Zureik, Mahmoud Bauters, Christophe Grupposo, Marie-Catherine Cottel, Dominique Montaye, Michèle Hamon, Martial Ducimetière, Pierre Amouyel, Philippe Brousseau, Thierry |
| description | OBJECTIVE—Proliferation and migration of vascular smooth muscle cells (VSMCs) are striking features shared by vascular ageing, atherosclerosis, and in-stent restenosis. VSMC biology depends in part on polyamines whose metabolism is closely regulated by ornithine decarboxylase antizyme 1 (OAZ1). Therefore, we sought for association between OAZ1 gene polymorphisms and various outcomes involving VSMC proliferation.
METHODS AND RESULTS—Systematic screening of the OAZ1 gene enabled to detect 21 variants. The impact of 4 selected tag polymorphisms (+849C/T, +851G/T, +1804G/A, and +2222A/G) was evaluated in 3 independent association studies. In a sample of 205 patients, the +2222G allele was associated with an increased risk of 6-month coronary in-stent restenosis (OR [95%CI]=2.1 [1.2 to 3.6]; P=0.0071). In a sample of 1001 subjects participating to the EVA study, the +2222G allele was longitudinally associated with a 4-year increase in common carotid intima-media thickness (P=0.047). In a case-control study (466 cases versus 466 controls), the risk of coronary heart disease associated with the +2222G allele was 1.3 (95%CI=[1.1 to 1.6]; P=0.026). No other significant association was consistently detected.
CONCLUSIONS—We identified the OAZ1+2222A/G polymorphism as a potential genetic marker of vascular events. Our findings strengthen the hypothesis that the polyamine metabolism plays a role in vascular diseases. |
| doi_str_mv | 10.1161/ATVBAHA.107.150458 |
| format | Article |
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METHODS AND RESULTS—Systematic screening of the OAZ1 gene enabled to detect 21 variants. The impact of 4 selected tag polymorphisms (+849C/T, +851G/T, +1804G/A, and +2222A/G) was evaluated in 3 independent association studies. In a sample of 205 patients, the +2222G allele was associated with an increased risk of 6-month coronary in-stent restenosis (OR [95%CI]=2.1 [1.2 to 3.6]; P=0.0071). In a sample of 1001 subjects participating to the EVA study, the +2222G allele was longitudinally associated with a 4-year increase in common carotid intima-media thickness (P=0.047). In a case-control study (466 cases versus 466 controls), the risk of coronary heart disease associated with the +2222G allele was 1.3 (95%CI=[1.1 to 1.6]; P=0.026). No other significant association was consistently detected.
CONCLUSIONS—We identified the OAZ1+2222A/G polymorphism as a potential genetic marker of vascular events. Our findings strengthen the hypothesis that the polyamine metabolism plays a role in vascular diseases.</description><identifier>ISSN: 1079-5642</identifier><identifier>EISSN: 1524-4636</identifier><identifier>DOI: 10.1161/ATVBAHA.107.150458</identifier><identifier>PMID: 17761941</identifier><identifier>CODEN: ATVBFA</identifier><language>eng</language><publisher>Philadelphia, PA: American Heart Association, Inc</publisher><subject>Aged ; Associated diseases and complications ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Cardiovascular Diseases - enzymology ; Cardiovascular Diseases - genetics ; Cardiovascular Diseases - pathology ; Carotid Artery Diseases - enzymology ; Carotid Artery Diseases - genetics ; Carotid Artery Diseases - pathology ; Case-Control Studies ; Cell Proliferation ; Coronary Disease - enzymology ; Coronary Disease - genetics ; Coronary Disease - pathology ; Coronary Restenosis - enzymology ; Coronary Restenosis - genetics ; Coronary Restenosis - pathology ; Diabetes. Impaired glucose tolerance ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Female ; Fundamental and applied biological sciences. Psychology ; Gene Frequency ; General aspects ; Genetic Predisposition to Disease ; Humans ; Linkage Disequilibrium ; Longitudinal Studies ; Male ; Medical sciences ; Middle Aged ; Muscle, Smooth, Vascular - enzymology ; Muscle, Smooth, Vascular - pathology ; Myocytes, Smooth Muscle - enzymology ; Myocytes, Smooth Muscle - pathology ; Odds Ratio ; Phenotype ; Polyamines - metabolism ; Polymorphism, Single Nucleotide ; Proteins - genetics ; Risk Assessment ; Risk Factors ; Vertebrates: cardiovascular system</subject><ispartof>Arteriosclerosis, thrombosis, and vascular biology, 2007-10, Vol.27 (10), p.2120-2126</ispartof><rights>2007 American Heart Association, Inc.</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4558-e935c07abfe3a7a28433c7c6aa2a64dde54d5512eadbf8a4ae566faa27fb4e6b3</citedby><cites>FETCH-LOGICAL-c4558-e935c07abfe3a7a28433c7c6aa2a64dde54d5512eadbf8a4ae566faa27fb4e6b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19106512$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17761941$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dumont, Julie</creatorcontrib><creatorcontrib>Zureik, Mahmoud</creatorcontrib><creatorcontrib>Bauters, Christophe</creatorcontrib><creatorcontrib>Grupposo, Marie-Catherine</creatorcontrib><creatorcontrib>Cottel, Dominique</creatorcontrib><creatorcontrib>Montaye, Michèle</creatorcontrib><creatorcontrib>Hamon, Martial</creatorcontrib><creatorcontrib>Ducimetière, Pierre</creatorcontrib><creatorcontrib>Amouyel, Philippe</creatorcontrib><creatorcontrib>Brousseau, Thierry</creatorcontrib><title>Association of OAZ1 Gene Polymorphisms With Subclinical and Clinical Vascular Events</title><title>Arteriosclerosis, thrombosis, and vascular biology</title><addtitle>Arterioscler Thromb Vasc Biol</addtitle><description>OBJECTIVE—Proliferation and migration of vascular smooth muscle cells (VSMCs) are striking features shared by vascular ageing, atherosclerosis, and in-stent restenosis. VSMC biology depends in part on polyamines whose metabolism is closely regulated by ornithine decarboxylase antizyme 1 (OAZ1). Therefore, we sought for association between OAZ1 gene polymorphisms and various outcomes involving VSMC proliferation.
METHODS AND RESULTS—Systematic screening of the OAZ1 gene enabled to detect 21 variants. The impact of 4 selected tag polymorphisms (+849C/T, +851G/T, +1804G/A, and +2222A/G) was evaluated in 3 independent association studies. In a sample of 205 patients, the +2222G allele was associated with an increased risk of 6-month coronary in-stent restenosis (OR [95%CI]=2.1 [1.2 to 3.6]; P=0.0071). In a sample of 1001 subjects participating to the EVA study, the +2222G allele was longitudinally associated with a 4-year increase in common carotid intima-media thickness (P=0.047). In a case-control study (466 cases versus 466 controls), the risk of coronary heart disease associated with the +2222G allele was 1.3 (95%CI=[1.1 to 1.6]; P=0.026). No other significant association was consistently detected.
CONCLUSIONS—We identified the OAZ1+2222A/G polymorphism as a potential genetic marker of vascular events. Our findings strengthen the hypothesis that the polyamine metabolism plays a role in vascular diseases.</description><subject>Aged</subject><subject>Associated diseases and complications</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular Diseases - enzymology</subject><subject>Cardiovascular Diseases - genetics</subject><subject>Cardiovascular Diseases - pathology</subject><subject>Carotid Artery Diseases - enzymology</subject><subject>Carotid Artery Diseases - genetics</subject><subject>Carotid Artery Diseases - pathology</subject><subject>Case-Control Studies</subject><subject>Cell Proliferation</subject><subject>Coronary Disease - enzymology</subject><subject>Coronary Disease - genetics</subject><subject>Coronary Disease - pathology</subject><subject>Coronary Restenosis - enzymology</subject><subject>Coronary Restenosis - genetics</subject><subject>Coronary Restenosis - pathology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Frequency</subject><subject>General aspects</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Linkage Disequilibrium</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Muscle, Smooth, Vascular - enzymology</subject><subject>Muscle, Smooth, Vascular - pathology</subject><subject>Myocytes, Smooth Muscle - enzymology</subject><subject>Myocytes, Smooth Muscle - pathology</subject><subject>Odds Ratio</subject><subject>Phenotype</subject><subject>Polyamines - metabolism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Proteins - genetics</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Vertebrates: cardiovascular system</subject><issn>1079-5642</issn><issn>1524-4636</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkU9v1DAQxS0EoqXwBTggX-CWxXb8JzmGVWkrVSoSS5G4WBNnog048WInVP32eLWpehnPk3_zNH4m5D1nG841_9zs7r80182GM7PhiklVvSDnXAlZSF3ql7lnpi6UluKMvEnpN2NMCsFekzNujOa15Odk16QU3ADzECYaenrX_OL0Ciek34J_HEM87Ic0JvpzmPf0-9I6P0yDA09h6uj2SdxDcouHSC__4TSnt-RVDz7hu_W8ID--Xu6218Xt3dXNtrktnFSqKrAulWMG2h5LMCAqWZbOOA0gQMuuQyU7pbhA6Nq-AgmotO7zrelbibotL8ink-8hhr8LptmOQ3LoPUwYlmR1JWrFTZVBcQJdDClF7O0hDiPER8uZPWZp1yyzNvaUZR76sLov7Yjd88gaXgY-rkB-Pvg-wuSG9MzVnOm8fubkiXsIfsaY_vjlAaPdI_h5b4-_UmqmCsGY4Vmx4liq8j8FdYzs</recordid><startdate>200710</startdate><enddate>200710</enddate><creator>Dumont, Julie</creator><creator>Zureik, Mahmoud</creator><creator>Bauters, Christophe</creator><creator>Grupposo, Marie-Catherine</creator><creator>Cottel, Dominique</creator><creator>Montaye, Michèle</creator><creator>Hamon, Martial</creator><creator>Ducimetière, Pierre</creator><creator>Amouyel, Philippe</creator><creator>Brousseau, Thierry</creator><general>American Heart Association, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200710</creationdate><title>Association of OAZ1 Gene Polymorphisms With Subclinical and Clinical Vascular Events</title><author>Dumont, Julie ; Zureik, Mahmoud ; Bauters, Christophe ; Grupposo, Marie-Catherine ; Cottel, Dominique ; Montaye, Michèle ; Hamon, Martial ; Ducimetière, Pierre ; Amouyel, Philippe ; Brousseau, Thierry</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4558-e935c07abfe3a7a28433c7c6aa2a64dde54d5512eadbf8a4ae566faa27fb4e6b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Aged</topic><topic>Associated diseases and complications</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular Diseases - enzymology</topic><topic>Cardiovascular Diseases - genetics</topic><topic>Cardiovascular Diseases - pathology</topic><topic>Carotid Artery Diseases - enzymology</topic><topic>Carotid Artery Diseases - genetics</topic><topic>Carotid Artery Diseases - pathology</topic><topic>Case-Control Studies</topic><topic>Cell Proliferation</topic><topic>Coronary Disease - enzymology</topic><topic>Coronary Disease - genetics</topic><topic>Coronary Disease - pathology</topic><topic>Coronary Restenosis - enzymology</topic><topic>Coronary Restenosis - genetics</topic><topic>Coronary Restenosis - pathology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Frequency</topic><topic>General aspects</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Linkage Disequilibrium</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Muscle, Smooth, Vascular - enzymology</topic><topic>Muscle, Smooth, Vascular - pathology</topic><topic>Myocytes, Smooth Muscle - enzymology</topic><topic>Myocytes, Smooth Muscle - pathology</topic><topic>Odds Ratio</topic><topic>Phenotype</topic><topic>Polyamines - metabolism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Proteins - genetics</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Vertebrates: cardiovascular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dumont, Julie</creatorcontrib><creatorcontrib>Zureik, Mahmoud</creatorcontrib><creatorcontrib>Bauters, Christophe</creatorcontrib><creatorcontrib>Grupposo, Marie-Catherine</creatorcontrib><creatorcontrib>Cottel, Dominique</creatorcontrib><creatorcontrib>Montaye, Michèle</creatorcontrib><creatorcontrib>Hamon, Martial</creatorcontrib><creatorcontrib>Ducimetière, Pierre</creatorcontrib><creatorcontrib>Amouyel, Philippe</creatorcontrib><creatorcontrib>Brousseau, Thierry</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Arteriosclerosis, thrombosis, and vascular biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dumont, Julie</au><au>Zureik, Mahmoud</au><au>Bauters, Christophe</au><au>Grupposo, Marie-Catherine</au><au>Cottel, Dominique</au><au>Montaye, Michèle</au><au>Hamon, Martial</au><au>Ducimetière, Pierre</au><au>Amouyel, Philippe</au><au>Brousseau, Thierry</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of OAZ1 Gene Polymorphisms With Subclinical and Clinical Vascular Events</atitle><jtitle>Arteriosclerosis, thrombosis, and vascular biology</jtitle><addtitle>Arterioscler Thromb Vasc Biol</addtitle><date>2007-10</date><risdate>2007</risdate><volume>27</volume><issue>10</issue><spage>2120</spage><epage>2126</epage><pages>2120-2126</pages><issn>1079-5642</issn><eissn>1524-4636</eissn><coden>ATVBFA</coden><abstract>OBJECTIVE—Proliferation and migration of vascular smooth muscle cells (VSMCs) are striking features shared by vascular ageing, atherosclerosis, and in-stent restenosis. VSMC biology depends in part on polyamines whose metabolism is closely regulated by ornithine decarboxylase antizyme 1 (OAZ1). Therefore, we sought for association between OAZ1 gene polymorphisms and various outcomes involving VSMC proliferation.
METHODS AND RESULTS—Systematic screening of the OAZ1 gene enabled to detect 21 variants. The impact of 4 selected tag polymorphisms (+849C/T, +851G/T, +1804G/A, and +2222A/G) was evaluated in 3 independent association studies. In a sample of 205 patients, the +2222G allele was associated with an increased risk of 6-month coronary in-stent restenosis (OR [95%CI]=2.1 [1.2 to 3.6]; P=0.0071). In a sample of 1001 subjects participating to the EVA study, the +2222G allele was longitudinally associated with a 4-year increase in common carotid intima-media thickness (P=0.047). In a case-control study (466 cases versus 466 controls), the risk of coronary heart disease associated with the +2222G allele was 1.3 (95%CI=[1.1 to 1.6]; P=0.026). No other significant association was consistently detected.
CONCLUSIONS—We identified the OAZ1+2222A/G polymorphism as a potential genetic marker of vascular events. Our findings strengthen the hypothesis that the polyamine metabolism plays a role in vascular diseases.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>17761941</pmid><doi>10.1161/ATVBAHA.107.150458</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Associated diseases and complications Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular Diseases - enzymology Cardiovascular Diseases - genetics Cardiovascular Diseases - pathology Carotid Artery Diseases - enzymology Carotid Artery Diseases - genetics Carotid Artery Diseases - pathology Case-Control Studies Cell Proliferation Coronary Disease - enzymology Coronary Disease - genetics Coronary Disease - pathology Coronary Restenosis - enzymology Coronary Restenosis - genetics Coronary Restenosis - pathology Diabetes. Impaired glucose tolerance Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Endocrine pancreas. Apud cells (diseases) Endocrinopathies Female Fundamental and applied biological sciences. Psychology Gene Frequency General aspects Genetic Predisposition to Disease Humans Linkage Disequilibrium Longitudinal Studies Male Medical sciences Middle Aged Muscle, Smooth, Vascular - enzymology Muscle, Smooth, Vascular - pathology Myocytes, Smooth Muscle - enzymology Myocytes, Smooth Muscle - pathology Odds Ratio Phenotype Polyamines - metabolism Polymorphism, Single Nucleotide Proteins - genetics Risk Assessment Risk Factors Vertebrates: cardiovascular system |
| title | Association of OAZ1 Gene Polymorphisms With Subclinical and Clinical Vascular Events |
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