Serum NT-proBNP Concentrations in the Early Phase Do Not Predict the Severity of Systolic or Diastolic Left Ventricular Dysfunction Among Patients With ST-Elevation Acute Myocardial Infarction
The cohort included 55 consecutive patients with first ST elevation acute myocardial infarction (STEAMI) who underwent reperfusion. Blood samples were drawn for N-terminal pro B-type natriuretic peptide (NT-proBNP), highly-sensitive C-reactive protein (hs-CRP), creatinine kinase (CK), cardiac tropon...
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| Veröffentlicht in: | Angiology 2006-12, Vol.57 (6), p.686-693 |
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| creator | Ben-Dor, Itsik Haim, Moti Rechavia, Eldad Murninkas, Daniel Harell, Daniella Porter, Avital Iakobishvili, Zaza Battler, Alexander Hasdai, David |
| description | The cohort included 55 consecutive patients with first ST elevation acute myocardial infarction (STEAMI) who underwent reperfusion. Blood samples were drawn for N-terminal pro B-type natriuretic peptide (NT-proBNP), highly-sensitive C-reactive protein (hs-CRP), creatinine kinase (CK), cardiac troponin l (cTnl), and white blood cell (WBC) count within 24 hours of admission. Transthoracic echocardiography, performed within the same time frame, assessed left ventricular (LV) systolic function, as well as diastolic function. Variables significantly associated with poor systolic LV dysfunction were hs-CRP, peak CK, cTnl, and WBC. There was no significant correlation between NT-proBNP and systolic function early after STEAMI (p=0.49). Among patients with diastolic dysfunction, there was no significant correlation between NT-proBNP levels and peak mitral E-wave velocity to peak initial A-wave velocity (E/A ratio) (r =0.19, p=0.18) or E-wave deceleration time (r =0.22, p=0.15). Thus, NT-proBNP levels in the early phase after STEAMI were not indicative of systolic or diastolic function. |
| doi_str_mv | 10.1177/0003319706295228 |
| format | Article |
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Blood samples were drawn for N-terminal pro B-type natriuretic peptide (NT-proBNP), highly-sensitive C-reactive protein (hs-CRP), creatinine kinase (CK), cardiac troponin l (cTnl), and white blood cell (WBC) count within 24 hours of admission. Transthoracic echocardiography, performed within the same time frame, assessed left ventricular (LV) systolic function, as well as diastolic function. Variables significantly associated with poor systolic LV dysfunction were hs-CRP, peak CK, cTnl, and WBC. There was no significant correlation between NT-proBNP and systolic function early after STEAMI (p=0.49). Among patients with diastolic dysfunction, there was no significant correlation between NT-proBNP levels and peak mitral E-wave velocity to peak initial A-wave velocity (E/A ratio) (r =0.19, p=0.18) or E-wave deceleration time (r =0.22, p=0.15). Thus, NT-proBNP levels in the early phase after STEAMI were not indicative of systolic or diastolic function.</description><identifier>ISSN: 0003-3197</identifier><identifier>EISSN: 1940-1574</identifier><identifier>DOI: 10.1177/0003319706295228</identifier><identifier>PMID: 17235108</identifier><identifier>CODEN: ANGIAB</identifier><language>eng</language><publisher>Thousand Oaks, CA: SAGE Publications</publisher><subject>Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Blood and lymphatic vessels ; C-Reactive Protein - analysis ; Cardiology. Vascular system ; Coronary heart disease ; Creatine Kinase - blood ; Diastole ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Echocardiography ; Electrocardiography ; Female ; Heart ; Humans ; Leukocyte Count ; Male ; Medical sciences ; Middle Aged ; Myocardial Infarction - blood ; Myocardial Infarction - complications ; Myocardial Infarction - physiopathology ; Natriuretic Peptide, Brain - blood ; Peptide Fragments - blood ; Prospective Studies ; Systole ; Troponin I - blood ; Ventricular Dysfunction, Left - blood ; Ventricular Dysfunction, Left - etiology</subject><ispartof>Angiology, 2006-12, Vol.57 (6), p.686-693</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-a1ed94ea7fdbb9dfd221639165e209f523c2cf8028ffe761e15b4f0268d1f6be3</citedby><cites>FETCH-LOGICAL-c365t-a1ed94ea7fdbb9dfd221639165e209f523c2cf8028ffe761e15b4f0268d1f6be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0003319706295228$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0003319706295228$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18385085$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17235108$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ben-Dor, Itsik</creatorcontrib><creatorcontrib>Haim, Moti</creatorcontrib><creatorcontrib>Rechavia, Eldad</creatorcontrib><creatorcontrib>Murninkas, Daniel</creatorcontrib><creatorcontrib>Harell, Daniella</creatorcontrib><creatorcontrib>Porter, Avital</creatorcontrib><creatorcontrib>Iakobishvili, Zaza</creatorcontrib><creatorcontrib>Battler, Alexander</creatorcontrib><creatorcontrib>Hasdai, David</creatorcontrib><title>Serum NT-proBNP Concentrations in the Early Phase Do Not Predict the Severity of Systolic or Diastolic Left Ventricular Dysfunction Among Patients With ST-Elevation Acute Myocardial Infarction</title><title>Angiology</title><addtitle>Angiology</addtitle><description>The cohort included 55 consecutive patients with first ST elevation acute myocardial infarction (STEAMI) who underwent reperfusion. Blood samples were drawn for N-terminal pro B-type natriuretic peptide (NT-proBNP), highly-sensitive C-reactive protein (hs-CRP), creatinine kinase (CK), cardiac troponin l (cTnl), and white blood cell (WBC) count within 24 hours of admission. Transthoracic echocardiography, performed within the same time frame, assessed left ventricular (LV) systolic function, as well as diastolic function. Variables significantly associated with poor systolic LV dysfunction were hs-CRP, peak CK, cTnl, and WBC. There was no significant correlation between NT-proBNP and systolic function early after STEAMI (p=0.49). Among patients with diastolic dysfunction, there was no significant correlation between NT-proBNP levels and peak mitral E-wave velocity to peak initial A-wave velocity (E/A ratio) (r =0.19, p=0.18) or E-wave deceleration time (r =0.22, p=0.15). Thus, NT-proBNP levels in the early phase after STEAMI were not indicative of systolic or diastolic function.</description><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>C-Reactive Protein - analysis</subject><subject>Cardiology. Vascular system</subject><subject>Coronary heart disease</subject><subject>Creatine Kinase - blood</subject><subject>Diastole</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Echocardiography</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Heart</subject><subject>Humans</subject><subject>Leukocyte Count</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - blood</subject><subject>Myocardial Infarction - complications</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Natriuretic Peptide, Brain - blood</subject><subject>Peptide Fragments - blood</subject><subject>Prospective Studies</subject><subject>Systole</subject><subject>Troponin I - blood</subject><subject>Ventricular Dysfunction, Left - blood</subject><subject>Ventricular Dysfunction, Left - etiology</subject><issn>0003-3197</issn><issn>1940-1574</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU9v1DAQxS0EokvhzgnNBW4B2_nnHMt2KZWWZaVd4Bg5zrjrKhu3tlMp346PVqcbqRISJ3v0fm-eNI-Q94x-Zqwsv1BK05RVJS14lXMuXpAFqzKasLzMXpLFJCeTfkbeeH8bx5zR4jU5YyVP41csyN8duuEIm31y5-zXzRaWtlfYByeDsb0H00M4IKyk60bYHqRHuLSwsQG2DlujwpO8wwd0JoxgNexGH2xnFFgHl0bOwxp1gN_TYqOGTkZp9Hro1ZQCF0fb38A2RkbAwx8TDrDbJ6sOH-QJUENA-DFaJV1rZAfXvZbuyfyWvNKy8_hufs_Jr2-r_fJ7sv55db28WCcqLfKQSIZtlaEsdds0VatbzlmRVqzIkdNK5zxVXGlBudAay4Ihy5tMU16IlumiwfScfDrtjXe6H9CH-mi8wq6TPdrB14XgVSayMoL0BCpnvXeo6ztnjtKNNaP11Fr9b2vR8mHePTRHbJ8Nc00R-DgD0ivZaSd7ZfwzJ1KRU5FHLjlxXt5gfWsH18eb_D_4EWnUry4</recordid><startdate>20061201</startdate><enddate>20061201</enddate><creator>Ben-Dor, Itsik</creator><creator>Haim, Moti</creator><creator>Rechavia, Eldad</creator><creator>Murninkas, Daniel</creator><creator>Harell, Daniella</creator><creator>Porter, Avital</creator><creator>Iakobishvili, Zaza</creator><creator>Battler, Alexander</creator><creator>Hasdai, David</creator><general>SAGE Publications</general><general>Westminster</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20061201</creationdate><title>Serum NT-proBNP Concentrations in the Early Phase Do Not Predict the Severity of Systolic or Diastolic Left Ventricular Dysfunction Among Patients With ST-Elevation Acute Myocardial Infarction</title><author>Ben-Dor, Itsik ; Haim, Moti ; Rechavia, Eldad ; Murninkas, Daniel ; Harell, Daniella ; Porter, Avital ; Iakobishvili, Zaza ; Battler, Alexander ; Hasdai, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-a1ed94ea7fdbb9dfd221639165e209f523c2cf8028ffe761e15b4f0268d1f6be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>C-Reactive Protein - analysis</topic><topic>Cardiology. Vascular system</topic><topic>Coronary heart disease</topic><topic>Creatine Kinase - blood</topic><topic>Diastole</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>Echocardiography</topic><topic>Electrocardiography</topic><topic>Female</topic><topic>Heart</topic><topic>Humans</topic><topic>Leukocyte Count</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - blood</topic><topic>Myocardial Infarction - complications</topic><topic>Myocardial Infarction - physiopathology</topic><topic>Natriuretic Peptide, Brain - blood</topic><topic>Peptide Fragments - blood</topic><topic>Prospective Studies</topic><topic>Systole</topic><topic>Troponin I - blood</topic><topic>Ventricular Dysfunction, Left - blood</topic><topic>Ventricular Dysfunction, Left - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ben-Dor, Itsik</creatorcontrib><creatorcontrib>Haim, Moti</creatorcontrib><creatorcontrib>Rechavia, Eldad</creatorcontrib><creatorcontrib>Murninkas, Daniel</creatorcontrib><creatorcontrib>Harell, Daniella</creatorcontrib><creatorcontrib>Porter, Avital</creatorcontrib><creatorcontrib>Iakobishvili, Zaza</creatorcontrib><creatorcontrib>Battler, Alexander</creatorcontrib><creatorcontrib>Hasdai, David</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Angiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ben-Dor, Itsik</au><au>Haim, Moti</au><au>Rechavia, Eldad</au><au>Murninkas, Daniel</au><au>Harell, Daniella</au><au>Porter, Avital</au><au>Iakobishvili, Zaza</au><au>Battler, Alexander</au><au>Hasdai, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum NT-proBNP Concentrations in the Early Phase Do Not Predict the Severity of Systolic or Diastolic Left Ventricular Dysfunction Among Patients With ST-Elevation Acute Myocardial Infarction</atitle><jtitle>Angiology</jtitle><addtitle>Angiology</addtitle><date>2006-12-01</date><risdate>2006</risdate><volume>57</volume><issue>6</issue><spage>686</spage><epage>693</epage><pages>686-693</pages><issn>0003-3197</issn><eissn>1940-1574</eissn><coden>ANGIAB</coden><abstract>The cohort included 55 consecutive patients with first ST elevation acute myocardial infarction (STEAMI) who underwent reperfusion. Blood samples were drawn for N-terminal pro B-type natriuretic peptide (NT-proBNP), highly-sensitive C-reactive protein (hs-CRP), creatinine kinase (CK), cardiac troponin l (cTnl), and white blood cell (WBC) count within 24 hours of admission. Transthoracic echocardiography, performed within the same time frame, assessed left ventricular (LV) systolic function, as well as diastolic function. Variables significantly associated with poor systolic LV dysfunction were hs-CRP, peak CK, cTnl, and WBC. There was no significant correlation between NT-proBNP and systolic function early after STEAMI (p=0.49). Among patients with diastolic dysfunction, there was no significant correlation between NT-proBNP levels and peak mitral E-wave velocity to peak initial A-wave velocity (E/A ratio) (r =0.19, p=0.18) or E-wave deceleration time (r =0.22, p=0.15). Thus, NT-proBNP levels in the early phase after STEAMI were not indicative of systolic or diastolic function.</abstract><cop>Thousand Oaks, CA</cop><pub>SAGE Publications</pub><pmid>17235108</pmid><doi>10.1177/0003319706295228</doi><tpages>8</tpages></addata></record> |
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| ispartof | Angiology, 2006-12, Vol.57 (6), p.686-693 |
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| subjects | Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels C-Reactive Protein - analysis Cardiology. Vascular system Coronary heart disease Creatine Kinase - blood Diastole Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Echocardiography Electrocardiography Female Heart Humans Leukocyte Count Male Medical sciences Middle Aged Myocardial Infarction - blood Myocardial Infarction - complications Myocardial Infarction - physiopathology Natriuretic Peptide, Brain - blood Peptide Fragments - blood Prospective Studies Systole Troponin I - blood Ventricular Dysfunction, Left - blood Ventricular Dysfunction, Left - etiology |
| title | Serum NT-proBNP Concentrations in the Early Phase Do Not Predict the Severity of Systolic or Diastolic Left Ventricular Dysfunction Among Patients With ST-Elevation Acute Myocardial Infarction |
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